Amir H. Rezvani
Professor in Psychiatry and Behavioral Sciences
Education & Training
Ph.D., University of Illinois -- Urbana-Champaign 1983
Alcoholism: I work with "alcoholic" rats with genetic predisposition!" We use selectively-bred alcohol preferring rats as an animal model of human alcoholism for developing better pharmacological treatments for alcoholism. Recently, we are working on several novel promissing "anti-craving" compounds for the treatment of alcoholism. We are also studing the interaction bewteen alcohol drinking and nicotine intake.
Nicotine Addiction: We have been studying age and sex differences in i.v. nicotine self-administration in rats. We have found that pattern of drug intake is both age- and sex-dependent. Our lab is also exploring different neuronal targets for developing better pharmacologic treatment for nicotine addiction.
Sustained Attention: Another aspect of our research is studying the role of the neuronal nicotinic and other neuronal systems in sustained attention using a rodent model. We have shown, nicotine (not smoking!) and nicotinic compounds improve attention in rats. A majority of people with schizophrenia smoke and they smoke heavily. Thus, it is important to understand the interaction of antipsychotic medications and nicotine in sustained attention. This has been another aspect of our research with interesting results. Presently, we are testing novel nicotinic compounds for improving pharmacologically-impaired sustained attention.
Teaching: I love to teach and interact with students. Since arriving at Duke in 1999, I have been team-teaching the popular alcohol course (Psych 206-01R; Alcohol: Brain, Society and Individual). I also enjoy mentoring undergrad students who are interested in science and enjoy working in the lab with cute little creatures!.
Community: I am a member of the Board of Directors of Triangle Residential Options for Substance Abusers (TROSA), a self-supported therapeutic community in Durham. I also give seminars and workshops on addiction around the country.
Rezvani, AH, Slade, S, Wells, C, Yenugonda, VM, Liu, Y, Brown, ML, Xiao, Y, Kellar, KJ, and Levin, ED. "Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats." Psychopharmacology (May 29, 2017). Full Text
Rezvani, AH, Levin, ED, Cauley, M, Getachew, B, and Tizabi, Y. "Ketamine Differentially Attenuates Alcohol Intake in Male Versus Female Alcohol Preferring (P) Rats." Journal of Drug and Alcohol Research 6 (2017): 1-6. Full Text
Rezvani, AH, Cauley, MC, Slade, S, Wells, C, Glick, S, Rose, JE, and Levin, ED. "Acute oral 18-methoxycoronaridine (18-MC) decreases both alcohol intake and IV nicotine self-administration in rats." Pharmacology, biochemistry, and behavior 150-151 (November 2016): 153-157. Full Text
Levin, ED, Hall, BJ, Chattopadhyay, A, Slade, S, Wells, C, Rezvani, AH, and Rose, JE. "Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats." Psychopharmacology 233.15-16 (August 2016): 3009-3015. Full Text
Briggs, SA, Hall, BJ, Wells, C, Slade, S, Jaskowski, P, Morrison, M, Rezvani, AH, Rose, JE, and Levin, ED. "Dextromethorphan interactions with histaminergic and serotonergic treatments to reduce nicotine self-administration in rats." Pharmacology, biochemistry, and behavior 142 (March 2016): 1-7. Full Text
Rezvani, AH, Levin, ED, Arolfo, MP, Wells, C, Graupe, M, and Diamond, I. "Inhibition of Aldehyde Dehydrogenase-2 (ALDH-2) Suppresses Nicotine Self-Administration in Rats." Journal of Drug and Alcohol Research 4 (2016): 1-6. Full Text
Rezvani, AH, Levin, ED, Wells, C, Slade, S, Morrison, M, Marshall, L, Morris, M, Confino, J, Allenby, C, and Lumeng, L. "Different Lines of Rats Selectively-Bred for High Alcohol-Drinking Demonstrate Disparate Preferences for Nicotine Self-Administration." Journal of Drug and Alcohol Research 5 (2016): 1-9. Full Text Open Access Copy
Blanchard, H, Chang, L, Rezvani, AH, Rapoport, SI, and Taha, AY. "Brain Arachidonic Acid Incorporation and Turnover are not Altered in the Flinders Sensitive Line Rat Model of Human Depression." Neurochemical research 40.11 (November 2015): 2293-2303. Full Text
Levin, ED, Wells, C, Johnson, JE, Rezvani, AH, Bymaster, FP, and Rose, JE. "Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats." European journal of pharmacology 764 (October 2015): 30-37. Full Text
Levin, ED, Hall, BJ, and Rezvani, AH. "Heterogeneity across brain regions and neurotransmitter interactions with nicotinic effects on memory function." Current topics in behavioral neurosciences 23 (January 2015): 87-101. (Review) Full Text
Paternal Transgenerational Epigenetic Legacy from Use of Cannabis awarded by John Templeton Foundation (Co Investigator). 2017 to 2020
Study of Novel Treatment to Prevent Acquisition of Opiate Self-Administration in Rats awarded by Amygdala Neurosciences Inc. (Principal Investigator). 2017 to 2018
Targeted tobacco regulatory science: Nicotine dose effects in animal models of smoking initiation in vulnerable adolescent subpopulations awarded by Minneapolis Medical Research Foundation (Principal Investigator). 2016 to 2018
Nicotinic Receptor Desensitization to Reduce Drug Self-Administration: Project 2 awarded by Georgetown University (Co Investigator). 2010 to 2015
Adolescence: A Sensitive Period for Nicotine Addiction awarded by National Institutes of Health (Co Investigator). 2004 to 2010
Nicotinic-Antipsychotic Drug Interactions and Cognition awarded by National Institutes of Health (Co Investigator). 2001 to 2006