Andrew Sherwood

Professor in Psychiatry and Behavioral Sciences

Education & Training

  • Ph.D., University of Hull (England) 1972

Overview

My current research focus is on biological, behavioral and sociocultural factors involved in the etiology and management of hypertension, coronary artery disease, and congestive heart failure. The role of stress and the sympathetic nervous system in disease onset and progression is of central interest. Current research issues being studied include: (i) Ethnicity and gender as factors related to the pathogenesis of hypertension; (ii) Mechanisms by which menopause increases the risk of cardiovascular disease in women; (iii) Mechanisms by which stress may provoke episodes of myocardial ischemia in patients with coronary artery disease; (iv) Stress biomarkers that are associated with adverse clinical outcomes in cardiac patients; (v) The development of coping skills interventions to improve prognosis and quality of life in patients with congestive heart failure; (vi) Circadian blood pressure profiles for risk stratification in patients with hypertension; (vii) Biological and behavioral factors contributing to elevated nighttime blood pressure and blunted nighttime blood pressure dipping.

Comprehensive assessments of cardiovascular regulatory systems define the daily activity in the biobehavioral research laboratory. Assessments include: (i) hemodynamic (blood pressure, cardiac output, systemic vascular resistance) and neurohumoral responses (plasma epinephrine and norepinephrine) during psychological and physical stress testing; (ii) alpha and beta adrenergic receptor function, the baroreceptor reflex, and cardiac vagal control; (iii) endothelial function, and vascular structure and compliance; (iv) left ventricular structure and function by echocardiography; (v) 24-hour ambulatory blood pressure and cardiac output monitoring; (vi) Nonivasive assessments of arterial stiffness and central aortic pressure; (vii) Psychometric assessments of personality and lifestyle characteristics related to cardiovascular disease.

A secondary research interest is in the use and development of noninvasive techniques for evaluating the cardiovascular system. Developments include an ambulatory impedance cardiography system, permitting assessment of 24-hour hemodynamics during normal daily activities, and biomarkers of cardiovascular risk obtained using ultrasound imaging.

RESINT.DOC 1/5/99

Sherwood, A, Smith, PJ, Hinderliter, AL, Georgiades, A, and Blumenthal, JA. "Effects of exercise and stress management training on nighttime blood pressure dipping in patients with coronary heart disease: A randomized, controlled trial." American heart journal 183 (January 2017): 85-90. Full Text

Sherwood, A, Blumenthal, JA, Koch, GG, Hoffman, BM, Watkins, LL, Smith, PJ, O'Connor, CM, Adams, KF, Rogers, JG, Sueta, C, Chang, PP, Johnson, KS, Schwartz, J, and Hinderliter, AL. "Effects of Coping Skills Training on Quality of Life, Disease Biomarkers, and Clinical Outcomes in Patients With Heart Failure: A Randomized Clinical Trial." Circulation. Heart failure 10.1 (January 2017). Full Text

Dennis, PA, Kimbrel, NA, Sherwood, A, Calhoun, PS, Watkins, LL, Dennis, MF, and Beckham, JC. "Trauma and Autonomic Dysregulation: Episodic - Versus Systemic - Negative Affect Underlying Cardiovascular Risk in Posttraumatic Stress Disorder." Psychosomatic medicine (December 9, 2016).

Tyson, CC, Smith, PJ, Sherwood, A, Mabe, S, Hinderliter, AL, and Blumenthal, JA. "Influence of Kidney Function on Blood Pressure Response to Lifestyle Modifications: Secondary Analysis From the Exercise and Nutritional Interventions for Cardiovascular Health (ENCORE) Trial." Journal of clinical hypertension (Greenwich, Conn.) 18.12 (December 2016): 1260-1267. Full Text

Dennis, PA, Dedert, EA, Van Voorhees, EE, Watkins, LL, Hayano, J, Calhoun, PS, Sherwood, A, Dennis, MF, and Beckham, JC. "Examining the Crux of Autonomic Dysfunction in Posttraumatic Stress Disorder: Whether Chronic or Situational Distress Underlies Elevated Heart Rate and Attenuated Heart Rate Variability." Psychosomatic medicine 78.7 (September 2016): 805-809. Full Text

Paine, NJ, Hinderliter, AL, Blumenthal, JA, Adams, KF, Sueta, CA, Chang, PP, O'Connor, CM, and Sherwood, A. "Reactive hyperemia is associated with adverse clinical outcomes in heart failure." American heart journal 178 (August 2016): 108-114. Full Text

Hill, LK, Sherwood, A, Blumenthal, JA, and Hinderliter, AL. "Hemodynamics and Vascular Hypertrophy in African Americans and Caucasians With High Blood Pressure." American journal of hypertension (August 2016).

Sherwood, A, Blumenthal, JA, Smith, PJ, Watkins, LL, Hoffman, BM, and Hinderliter, AL. "Effects of Exercise and Sertraline on Measures of Coronary Heart Disease Risk in Patients With Major Depression: Results From the SMILE-II Randomized Clinical Trial." Psychosomatic medicine 78.5 (June 2016): 602-609. Full Text

Blumenthal, JA, Feger, BJ, Smith, PJ, Watkins, LL, Jiang, W, Davidson, J, Hoffman, BM, Ashworth, M, Mabe, SK, Babyak, MA, Kraus, WE, Hinderliter, A, and Sherwood, A. "Treatment of anxiety in patients with coronary heart disease: Rationale and design of the UNderstanding the benefits of exercise and escitalopram in anxious patients WIth coroNary heart Disease (UNWIND) randomized clinical trial." American heart journal 176 (June 2016): 53-62. Full Text

Hornik, CP, Sherwood, AL, Cotten, CM, Laughon, MM, Clark, RH, and Smith, PB. "Daily mortality of infants born at less than 30weeks' gestation." Early human development 96 (May 2016): 27-30. Full Text

Pages

Lett, HS, Sherwood, A, Watkins, L, and Blumenthal, JA. "Depression and prognosis in cardiac patients." Depression and Physical Illness. January 1, 2006. 87-108. Full Text

Smith, PJ, Blumenthal, JA, Hinderliter, AL, and Sherwood, A. "OBESITY IS ASSOCIATED WITH POORER NEUROCOGNITIVE PERFORMANCE AMONG ADULTS WITH HIGH BLOOD PRESSURE." April 2013.

Watkins, LL, Sherwood, A, Blumenthal, JA, Smith, PJ, Geordiades, A, and Jr, SMH. "NATURALISTIC STRESSORS ARE ASSOCIATED WITH REDUCED 24-HOUR HRV IN ACUTE POST-MI PATIENTS." April 2013.

Bacon, SL, Sherwood, A, Hinderliter, A, Babyak, M, Waugh, R, Georgiades, A, Coleman, RE, and Blumenthal, JA. "The effects of exercise training on mental stress-induced ischemia." 2006.

Bacon, SL, Sherwood, A, Hinderliter, A, Babyak, M, and Blumenthal, JA. "The effects of behavioral interventions on stress-induced cardiovascular changes." 2006.

Blumenthal, JA, Sherwood, A, LaCaille, LJ, Georgiades, A, and Goyal, T. "Lifestyle approaches to the treatment of hypertension." 2005.

Hinderliter, AL, Sherwood, A, Babyak, M, Gullette, EC, Georgiades, A, Watkins, L, Waugh, R, and Blumenthal, JA. "Persistence of reduced left ventricular hypertrophy after a supervised exercise and weight loss program." May 2004.

The Effect of Reducing Posttraumatic Stress Disorder Symptoms on Cardiovascular Risk awarded by National Institutes of Health (Co Investigator). 2016 to 2021

Exercise and Pharmacotherapy for Anxiety in Cardiac Patients awarded by National Institutes of Health (Co Investigator). 2015 to 2020

Neurocognition, Lifestyle Modification, and Treatment Resistant Hypertension awarded by National Institutes of Health (Co Investigator). 2016 to 2019

Facility and Web-based Approaches to Lifestyle Change in Resistant Hypertension awarded by National Institutes of Health (Co-Principal Investigator). 2014 to 2019

Depression and Heart Failure Disease Progression awarded by National Institutes of Health (Principal Investigator). 2014 to 2019

Social Cognition and Aging awarded by North Carolina State University (Principal Investigator). 2015 to 2017

Lifestyle, CVD Risk and Cognitive Impairment awarded by National Institutes of Health (Co Investigator). 2011 to 2017

Stress Management and Biomarkers of Risk in Cardiac Rehabilitation awarded by National Institutes of Health (Co Investigator). 2009 to 2016

Hostility, PTSD and Physical Health Risk Factors awarded by National Institutes of Health (Co Investigator). 2009 to 2015

Ancillary Investigation of Mental Stress Biomarkers in Coronary Heart Disease awarded by National Institutes of Health (Principal Investigator). 2010 to 2015

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