David Joseph Madden

Professor of Medical Psychology in the Department of Psychiatry and Behavioral Sciences

Education & Training

  • Ph.D., University of California at Davis 1977


My research focuses primarily on the cognitive neuroscience of aging: the investigation of age-related changes in perception, attention, and memory, using both behavioral measures and neuroimaging techniques, including positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and diffusion tensor imaging (DTI).

The behavioral measures have focused on reaction time, with the goal of distinguishing age-related changes in specific cognitive abilities from more general effects arising from a slowing in elementary perceptual processes. The cognitive abilities of interest include selective attention as measured in visual search tasks, semantic and episodic memory retrieval, and executive control processes.

The behavioral measures are necessary to define the cognitive abilities of interest, and the neuroimaging techniques help define the functional neuroanatomy of those abilities. The PET and fMRI measures provide information regarding neural activity during cognitive performance. DTI is a recently developed technique that images the structural integrity of white matter. The white matter tracts of the brain provide critical pathways linking the gray matter regions, and thus this work will complement the studies using PET and fMRI that focus on gray matter activation.

A current focus of the research program is the functional connectivity among regions, not only during cognitive task performance but also during rest. These latter measures, referred to as intrinsic functional connectivity, are beginning to show promise as an index of overall brain functional efficiency, which can be assessed without the implementation of a specific cognitive task. From DTI, information can be obtained regarding how anatomical connectivity constrains intrinsic functional connectivity. It will be important to determine the relative influence of white matter pathway integrity, intrinsic functional connectivity, and task-related functional connectivity, as mediators of age-related differences in behavioral measures of cognitive performance.

Ultimately, the research program can help link age-related changes in cognitive performance to changes in the structure and function of specific neural systems. The results also have implications for clinical translation, in terms of the identification of neural biomarkers for the diagnosis of neural pathology and targeting rehabilitation procedures.

Madden, DJ, Parks, EL, Tallman, CW, Boylan, MA, Hoagey, DA, Cocjin, SB, Johnson, MA, Chou, Y-H, Potter, GG, Chen, N-K, Packard, LE, Siciliano, RE, Monge, ZA, and Diaz, MT. "Frontoparietal activation during visual conjunction search: Effects of bottom-up guidance and adult age." Human brain mapping 38.4 (April 2017): 2128-2149. Full Text

Cordero, DM, Towe, SL, Chen, N-K, Robertson, KR, Madden, DJ, Huettel, SA, and Meade, CS. "Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection." Journal of neurovirology (March 2017). Full Text

Chou, Y-H, Sundman, M, Whitson, HE, Gaur, P, Chu, M-L, Weingarten, CP, Madden, DJ, Wang, L, Kirste, I, Joliot, M, Diaz, MT, Li, Y-J, Song, AW, and Chen, N-K. "Maintenance and Representation of Mind Wandering during Resting-State fMRI." Scientific reports 7 (January 12, 2017): 40722-. Full Text

Zhuang, J, Johnson, MA, Madden, DJ, Burke, DM, and Diaz, MT. "Age-related differences in resolving semantic and phonological competition during receptive language tasks." Neuropsychologia 93.Pt A (December 2016): 189-199. Full Text

Monge, ZA, and Madden, DJ. "Linking cognitive and visual perceptual decline in healthy aging: The information degradation hypothesis." Neuroscience and biobehavioral reviews 69 (October 2016): 166-173. Full Text

Melton, MS, Browndyke, JN, Harshbarger, TB, Madden, DJ, Nielsen, KC, and Klein, SM. "Changes in Brain Resting-state Functional Connectivity Associated with Peripheral Nerve Block: A Pilot Study." Anesthesiology 125.2 (August 2016): 368-377. Full Text Open Access Copy

Houston, JR, Bennett, IJ, Allen, PA, and Madden, DJ. "Visual Acuity does not Moderate Effect Sizes of Higher-Level Cognitive Tasks." Experimental aging research 42.3 (May 2016): 221-263. Full Text

Johnson, MA, Diaz, MT, and Madden, DJ. "Global versus tract-specific components of cerebral white matter integrity: relation to adult age and perceptual-motor speed." Brain structure & function 220.5 (September 2015): 2705-2720. Full Text

Whitson, HE, Chou, Y-H, Potter, GG, Diaz, MT, Chen, N-K, Lad, EM, Johnson, MA, Cousins, SW, Zhuang, J, and Madden, DJ. "Phonemic fluency and brain connectivity in age-related macular degeneration: a pilot study." Brain connectivity 5.2 (March 2015): 126-135. Full Text

Li, W, Langkammer, C, Chou, Y-H, Petrovic, K, Schmidt, R, Song, AW, Madden, DJ, Ropele, S, and Liu, C. "Association between increased magnetic susceptibility of deep gray matter nuclei and decreased motor function in healthy adults." NeuroImage 105 (January 2015): 45-52. Full Text


Madden, DJ, Whiting, WL, and Huettel, SA. "Age-related changes in neuralactivity during visual perception and attention." Cognitive Neuroscience of Aging: Linking cognitive and cerebral aging. May 1, 2009. Full Text

Salthouse, TA, and Madden, DJ. "Information processing speed and aging." Information Processing Speed in Clinical Populations. January 1, 2007. 221-241. Full Text

Madden, DJ, and Parks, EL. "Age differences in structural connectivity: Diffusion tensor imaging and white matter hyperintensities." Cognitive neuroscience of aging: Linking cognitive and cerebral aging (2nd Ed.). Trans. R Cabeza, L Nyberg, and DC Park.

Cognitive Changes and Brain Connectivity in Age-Related Macular Degeneration awarded by National Institutes of Health (Co Investigator). 2013 to 2018

Dorsal Cingulate Activity and Cognitive Decline in Late-Life Depression awarded by National Institutes of Health (Principal Investigator). 2012 to 2018

Effects of Aging on Visual Memory: Neuroimaging Studies awarded by National Institutes of Health (Co Investigator). 2001 to 2018

Imaging of Intrinsic Connectivity Networks awarded by National Institutes of Health (Co Investigator). 2011 to 2017

Neuroimaging of Visual Attention in Aging awarded by National Institutes of Health (Principal Investigator). 2011 to 2017

A Compute Cluster for Brain Imaging and Analysis awarded by National Institutes of Health (Major User). 2016 to 2017

Neural Substrates Associated with Executive Functioning in Marijuana and HIV awarded by National Institutes of Health (Investigator). 2014 to 2016

Behavior And Physiology In Aging awarded by National Institutes of Health (Mentor). 1999 to 2015

Neuroimaging of Age-Related Changes in Language awarded by National Institutes of Health (Co Investigator). 2010 to 2015

Anhedonia, Aging, and the Neural Correlates of Attentional Control in Depression awarded by National Institutes of Health (Co-Mentor). 2010 to 2015