Francis Joseph Keefe

Professor in Psychiatry and Behavioral Sciences

Education & Training

  • Ph.D., Ohio State University 1975

  • M.S., Ohio State University 1973

  • B.A., Bowdoin College 1971


The primary aim of our research over the past year has been to evaluate the efficacy of cognitive-behavioral treatments for arthritis pain. We are conducting two treatment outcome studies supported by grants from the National Institute of Arthritis, Musculoskeletal, and Skin Diseases. The first project, conducted with osteoarthritis patients, seeks to determine whether aerobic exercise training can enhance the effects of a cognitive behavior therapy (CBT) intervention for managing pain and disability. The CBT intervention is innovative in that it systematically involves spouses in training in pain coping skills. The second project, tests the long-term effectiveness of a relapse prevention training intervention. This study will feature the use of newly developed daily study methods to analyze the long-term effects of pain coping skills training on daily pain.

In addition, in conjunction with Lara Schanberg of the Department of Medicine we are carrying out a study funded by the Arthritis Foundation that examines the effects of a pain coping skills training regimen for pediatric fibromyalgia patients.

Finally, we are currently gathering pilot data for two new research projects. One project seeks to evaluate the efficacy of a cognitive behavior theapy and education intervention for managing pain in patients having breast cancer and prostate cancer. The second project examines the efficacy of patient controlled compression protocol in the management of pain during mammography.

Porter, LS, Keefe, FJ, Baucom, DH, Olsen, M, Zafar, SY, and Uronis, H. "A randomized pilot trial of a videoconference couples communication intervention for advanced GI cancer." Psycho-oncology 26.7 (July 2017): 1027-1035. Full Text

Balderson, BH, McCurry, SM, Vitiello, MV, Shortreed, SM, Rybarczyk, BD, Keefe, FJ, and Korff, MV. "Information without Implementation: A Practical Example for Developing a Best Practice Education Control Group." Behavioral sleep medicine 14.5 (September 2016): 514-527. Full Text

Huebner, JL, Landerman, LR, Somers, TJ, Keefe, FJ, Guilak, F, Blumenthal, JA, Caldwell, DS, and Kraus, VB. "Exploratory secondary analyses of a cognitive-behavioral intervention for knee osteoarthritis demonstrate reduction in biomarkers of adipocyte inflammation." Osteoarthritis and cartilage 24.9 (September 2016): 1528-1534. Full Text

Broderick, JE, Keefe, FJ, Schneider, S, Junghaenel, DU, Bruckenthal, P, Schwartz, JE, Kaell, AT, Caldwell, DS, McKee, D, and Gould, E. "Cognitive behavioral therapy for chronic pain is effective, but for whom?." Pain 157.9 (September 2016): 2115-2123. Full Text

Schrubbe, LA, Ravyts, SG, Benas, BC, Campbell, LC, Cené, CW, Coffman, CJ, Gunn, AH, Keefe, FJ, Nagle, CT, Oddone, EZ, Somers, TJ, Stanwyck, CL, Taylor, SS, and Allen, KD. "Pain coping skills training for African Americans with osteoarthritis (STAART): study protocol of a randomized controlled trial." BMC musculoskeletal disorders 17.1 (August 23, 2016): 359-. Full Text

Waters, SJ, Strauman, TJ, McKee, DC, Campbell, LC, Shelby, RA, Dixon, KE, Fras, AM, and Keefe, FJ. "Self-system therapy for distress associated with persistent low back pain: A randomized clinical trial." Psychotherapy research : journal of the Society for Psychotherapy Research 26.4 (July 2016): 472-483. Full Text Open Access Copy

Bennell, KL, Ahamed, Y, Jull, G, Bryant, C, Hunt, MA, Forbes, AB, Kasza, J, Akram, M, Metcalf, B, Harris, A, Egerton, T, Kenardy, JA, Nicholas, MK, and Keefe, FJ. "Physical Therapist-Delivered Pain Coping Skills Training and Exercise for Knee Osteoarthritis: Randomized Controlled Trial." Arthritis care & research 68.5 (May 2016): 590-602. Full Text

Soo, MS, Jarosz, JA, Wren, AA, Soo, AE, Mowery, YM, Johnson, KS, Yoon, SC, Kim, C, Hwang, ES, Keefe, FJ, and Shelby, RA. "Imaging-Guided Core-Needle Breast Biopsy: Impact of Meditation and Music Interventions on Patient Anxiety, Pain, and Fatigue." Journal of the American College of Radiology : JACR 13.5 (May 2016): 526-534. Full Text

Platts-Mills, TF, Nicholson, RJ, Richmond, NL, Patel, KV, Simonsick, EM, Domeier, RM, Swor, RA, Hendry, PL, Peak, DA, Rathlev, NK, Jones, JS, Lee, DC, Weaver, MA, Keefe, FJ, and McLean, SA. "Restricted activity and persistent pain following motor vehicle collision among older adults: a multicenter prospective cohort study." BMC geriatrics 16 (April 19, 2016): 86-. Full Text

Platts-Mills, TF, Flannigan, SA, Bortsov, AV, Smith, S, Domeier, RM, Swor, RA, Hendry, PL, Peak, DA, Rathlev, NK, Jones, JS, Lee, DC, Keefe, FJ, Sloane, PD, and McLean, SA. "Persistent Pain Among Older Adults Discharged Home From the Emergency Department After Motor Vehicle Crash: A Prospective Cohort Study." Annals of emergency medicine 67.2 (February 2016): 166-176.e1. Full Text


Somers, TJ, Keefe, FJ, Kothadia, S, and Pandiani, A. "Dealing with cancer pain: Coping, pain catastrophizing, and related outcomes." Cancer Pain: From Molecules to Suffering. June 1, 2015.

Naylor, MR, Seminowicz, DA, Somers, TJ, and Keefe, FJ. "Pain imaging." Handbook of Pain and Palliative Care: Biobehavioral Approaches for the Life Course. January 1, 2013. 439-467. Full Text

Keefe, FJ, Abernethy, AP, Wheeler, JL, and Somers, TJ. "Psychological interventions for cancer pain." Cancer Pain: Assessment and Management, Second Edition. January 1, 2009. 343-353. Full Text

Keefe, FJ. "Acute pain: A psychosocial perspective." Acute Pain Management. January 1, 2009. 41-52. Full Text

Musey, PI, Linnstaedt, SD, Platts-Mills, TF, Miner, JR, Bortsov, AV, Safdar, B, Bijur, P, Rosenau, A, Tsze, DS, Chang, AK, Dorai, S, Engel, KG, Feldman, JA, Fusaro, AM, Lee, DC, Rosenberg, M, Keefe, FJ, Peak, DA, Nam, CS, Patel, RG, Fillingim, RB, and McLean, SA. "Gender differences in acute and chronic pain in the emergency department: results of the 2014 Academic Emergency Medicine consensus conference pain section." December 2014. Full Text

Improving Adherence to Adjuvant Endocrine Therapy in Breast Cancer Patients awarded by National Institutes of Health (Co Investigator). 2016 to 2021

Optimizing Delivery of a Behavioral Cancer Pain Intervention Using a SMART awarded by National Institutes of Health (Co Investigator). 2016 to 2021

Meaning-centered Psychotherapy and Pain Coping Skills in Advanced Cancer awarded by American Cancer Society, Inc. (Principal Investigator). 2017 to 2020

A Self-Management Intervention for Women with Breast Cancer and Diabetes awarded by American Cancer Society, Inc. (Co Investigator). 2016 to 2020

Development of a Virtual Reality Graded Exposure Intervention for Chronic Low Back Pain awarded by The University of Texas at Dallas (Principal Investigator). 2016 to 2018

Behavioral Weight and Symptom Management for Breast Cancer Survivors and Partners awarded by National Institutes of Health (Principal Investigator). 2015 to 2018

Coping Skills for Colorectal Cancer Survivors with Pain and Distress awarded by American Cancer Society, Inc. (Principal Investigator). 2015 to 2018

Caregiver-Guided Pain Management Training in Palliative Care awarded by National Institutes of Health (Co-Principal Investigator). 2014 to 2018

An Accessible Mobile Health Behavioral Intervention for Cancer Pain (mPain) awarded by American Cancer Society, Inc. (Co Investigator). 2014 to 2018

Refinement and Expansion of the Palliative Care Research Cooperative Group awarded by National Institutes of Health (Investigator). 2013 to 2018