Ilene C. Siegler

Professor in Psychiatry and Behavioral Sciences

Education & Training

  • M.P.H., University of North Carolina at Chapel Hill 1988

  • Ph.D., Syracuse University


My research efforts are in the area of developmental health psychology and organized around understanding the role of personality in health and disease in middle and later life.

My primary research activity is as Principal Investigator of the UNC Alumni Heart Study (UNCAHS) a prospective epidemiologic study of 5000 middle aged men and women and 1200 of their spounses that evaluates the role of personality on coronary heart disease and coronary heart disease risk, cancer and normal aging.

As head of Cancer Prevention Research Unit , I study the role of psychological factors related to mammography behavior and estrogen replacement therapy is being studied in UNCAHS women.


Siegler, I.C., Zonderman, A.B., Barefoot, J.C., Williams, R.B., Jr., Costa, P.T., Jr., & McCrae, R. R. (1990). Predicting personality from college MMPI scores: Implications for follow-up studies in psychosomatic medicine. Psychosomatic Medicine, 52, 644-652.

Siegler, I.C., Peterson, B.L., Barefoot, J.C., & Williams, R.B. (1992). Hostility during late adolescence predicts coronary risk factors at midlife. American Journal of Epidemiology, 138(2), 146-154.

Siegler, I.C., Peterson, B.L., Barefoot, J.C., Harvin, S.H. Dahlstrom, W.G., Kaplan, B.H., Costa, P.T. Jr., & Williams, R.B. (1992). Using college alumni populations in epidemiologic research: The UNC Alumni Heart Study. Journal of Clinical Epidemiology, 45(11), 1243-1250.

Siegler, I.C., Dawson, D.V., & Welsh, K.A. (1994). Caregiver ratings of personality change in Alzheimer's disease patients: A replication. Psychology and Aging, 9, 464-466.

Siegler, I.C., Feaganes, J.R., & Rimer, B.K. (1995). Predictors of adoption of mammography in women under age 50. Health Psychology, 14, 274-278.


Williams, RB, Bishop, GD, Haberstick, BC, Smolen, A, Brummett, BH, Siegler, IC, Babyak, MA, Zhang, X, Tai, ES, Lee, JJ-M, Tan, M, Teo, YY, Cai, S, Chan, E, Halpern, CT, Whitsel, EA, Bauldry, S, and Harris, KM. "Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence." American heart journal 185 (March 2017): 110-122. Full Text

Jiang, R, Babyak, MA, Brummett, BH, Siegler, IC, Kuhn, CM, and Williams, RB. "Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress." Psychoneuroendocrinology 79 (February 13, 2017): 13-19. Full Text

Ogle, CM, Rubin, DC, and Siegler, IC. "Commentary—Pre- and Posttrauma Predictors of Posttraumatic Stress Disorder Symptom Severity: Reply to van der Velden and van der Knaap (2017)." Clinical Psychological Science 5.1 (January 1, 2017): 146-149. Full Text

Baek, Y, Martin, P, Siegler, IC, Davey, A, and Poon, LW. "Personality Traits and Successful Aging: Findings From the Georgia Centenarian Study." International journal of aging & human development 83.3 (September 2016): 207-227. Full Text

Ogle, CM, Siegler, IC, Beckham, JC, and Rubin, DC. "Neuroticism Increases PTSD Symptom Severity by Amplifying the Emotionality, Rehearsal, and Centrality of Trauma Memories." Journal of personality (August 12, 2016). Full Text

Ogle, CM, Rubin, DC, and Siegler, IC. "Maladaptive trauma appraisals mediate the relation between attachment anxiety and PTSD symptom severity." Psychological trauma : theory, research, practice and policy 8.3 (May 2016): 301-309. Full Text Open Access Copy

Ogle, CM, Rubin, DC, and Siegler, IC. "Accounting for Posttraumatic Stress Disorder Symptom Severity With Pre- and Posttrauma Measures: A Longitudinal Study of Older Adults." Clinical psychological science : a journal of the Association for Psychological Science 4.2 (March 2016): 272-286. Full Text Open Access Copy

Haberstick, BC, Boardman, JD, Wagner, B, Smolen, A, Hewitt, JK, Killeya-Jones, LA, Tabor, J, Halpern, CT, Brummett, BH, Williams, RB, Siegler, IC, Hopfer, CJ, and Mullan Harris, K. "Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health)." PloS one 11.3 (January 2016): e0148373-. Full Text

Ribeiro, JD, Yen, S, Joiner, T, and Siegler, IC. "Capability for suicide interacts with states of heightened arousal to predict death by suicide beyond the effects of depression and hopelessness." Journal of affective disorders 188 (December 2015): 53-59. Full Text

Singh, A, Babyak, MA, Brummett, BH, Jiang, R, Watkins, LL, Barefoot, JC, Kraus, WE, Shah, SH, Siegler, IC, Hauser, ER, and Williams, RB. "Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene." Genetic epidemiology 39.6 (September 2015): 489-497. Full Text


Behavioral and Physiology in Aging awarded by National Institutes of Health (Mentor). 2015 to 2020

A Model of Autobiographical Memory & Its Changes in PTSD awarded by National Institutes of Health (Senior Investigator). 2002 to 2016

Behavior And Physiology In Aging awarded by National Institutes of Health (Mentor). 1999 to 2015

Stress and Behavior in Health and Disease awarded by National Institutes of Health (Mentor). 1989 to 2011

Hostililty, Depression, Social Environment, and CHD Risk awarded by National Institutes of Health (Co Investigator). 1997 to 2009

Hostility, Race, and Glucose Metabolism awarded by National Institutes of Health (Co Investigator). 2003 to 2009

Surveillance And Analysis Of The UNC Alumni Heart Study awarded by National Institutes of Health (Principal Investigator). 1996 to 2007

Stress, Serotonin Genes, & Health Disparities awarded by National Institute of Environmental Health Science (Co-Principal Investigator). 2000 to 2006

Improving Cancer Risk Comunication awarded by National Institutes of Health (Principal Investigator). 1996 to 2003

Models of Personality, Health and Disease awarded by National Institutes of Health (Principal Investigator). 1995 to 2001