Ilene C. Siegler

Ilene C. Siegler

Professor in Psychiatry and Behavioral Sciences

Education & Training

  • M.P.H., University of North Carolina at Chapel Hill 1988

  • Ph.D., Syracuse University 1973


My research efforts are in the area of developmental health psychology and organized around understanding the role of personality in health and disease in middle and later life.

My primary research activity is as Principal Investigator of the UNC Alumni Heart Study (UNCAHS) a prospective epidemiologic study of 5000 middle aged men and women and 1200 of their spounses that evaluates the role of personality on coronary heart disease and coronary heart disease risk, cancer and normal aging.

As head of Cancer Prevention Research Unit , I study the role of psychological factors related to mammography behavior and estrogen replacement therapy is being studied in UNCAHS women.


Siegler, I.C., Zonderman, A.B., Barefoot, J.C., Williams, R.B., Jr., Costa, P.T., Jr., & McCrae, R. R. (1990). Predicting personality from college MMPI scores: Implications for follow-up studies in psychosomatic medicine. Psychosomatic Medicine, 52, 644-652.

Siegler, I.C., Peterson, B.L., Barefoot, J.C., & Williams, R.B. (1992). Hostility during late adolescence predicts coronary risk factors at midlife. American Journal of Epidemiology, 138(2), 146-154.

Siegler, I.C., Peterson, B.L., Barefoot, J.C., Harvin, S.H. Dahlstrom, W.G., Kaplan, B.H., Costa, P.T. Jr., & Williams, R.B. (1992). Using college alumni populations in epidemiologic research: The UNC Alumni Heart Study. Journal of Clinical Epidemiology, 45(11), 1243-1250.

Siegler, I.C., Dawson, D.V., & Welsh, K.A. (1994). Caregiver ratings of personality change in Alzheimer's disease patients: A replication. Psychology and Aging, 9, 464-466.

Siegler, I.C., Feaganes, J.R., & Rimer, B.K. (1995). Predictors of adoption of mammography in women under age 50. Health Psychology, 14, 274-278.


Williams, RB, Marchuk, DA, Siegler, IC, Barefoot, JC, Helms, MJ, Brummett, BH, Surwit, RS, Lane, JD, Kuhn, CM, Gadde, KM, Ashley-Koch, A, Svenson, IK, and Schanberg, SM. "Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress." Psychosom Med 70.1 (January 2008): 32-39. Full Text

Brummett, BH, Boyle, SH, Siegler, IC, Kuhn, CM, Ashley-Koch, A, Jonassaint, CR, Züchner, S, Collins, A, and Williams, RB. "Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR)." Behav Genet 38.1 (January 2008): 34-43. Full Text

Brummett, BH, Siegler, IC, Day, RS, and Costa, PT. "Personality as a predictor of dietary quality in spouses during midlife." Behav Med 34.1 (2008): 5-10. Full Text

Richman, LS, Bennett, GG, Pek, J, Siegler, I, and Williams, RB. "Discrimination, dispositions, and cardiovascular responses to stress." Health Psychol 26.6 (November 2007): 675-683. Full Text

Brummett, BH, Krystal, AD, Ashley-Koch, A, Kuhn, CM, Züchner, S, Siegler, IC, Barefoot, JC, Ballard, EL, Gwyther, LP, and Williams, RB. "Sleep quality varies as a function of 5-HTTLPR genotype and stress." Psychosom Med 69.7 (September 2007): 621-624. Full Text

Brummett, BH, Krystal, AD, Siegler, IC, Kuhn, C, Surwit, RS, Züchner, S, Ashley-Koch, A, Barefoot, JC, and Williams, RB. "Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality." Psychosom Med 69.5 (June 2007): 396-401. Full Text

Jonassaint, CR, Boyle, SH, Williams, RB, Mark, DB, Siegler, IC, and Barefoot, JC. "Facets of openness predict mortality in patients with cardiac disease." Psychosom Med 69.4 (May 2007): 319-322. Full Text

Martin, P, da Rosa, G, Siegler, IC, Davey, A, Macdonald, M, Poon, LW, and Georgia Centenarian Study, . "Personality and longevity: findings from the Georgia Centenarian Study." Age (Dordr) 28.4 (December 2006): 343-352. Full Text

Mortensen, LH, Siegler, IC, Barefoot, JC, Grønbaek, M, and Sørensen, TIA. "Prospective associations between sedentary lifestyle and BMI in midlife." Obesity (Silver Spring) 14.8 (August 2006): 1462-1471. Full Text