Ilene C. Siegler

Ilene C. Siegler

Professor in the Department of Psychology and Neuroscience

Education & Training

  • M.P.H., University of North Carolina at Chapel Hill 1988

  • Ph.D., Syracuse University 1973


My research efforts are in the area of developmental health psychology and organized around understanding the role of personality in health and disease in middle and later life.

My primary research activity is as Principal Investigator of the UNC Alumni Heart Study (UNCAHS) a prospective epidemiologic study of 5000 middle aged men and women and 1200 of their spounses that evaluates the role of personality on coronary heart disease and coronary heart disease risk, cancer and normal aging.

As head of Cancer Prevention Research Unit , I study the role of psychological factors related to mammography behavior and estrogen replacement therapy is being studied in UNCAHS women.


Siegler, I.C., Zonderman, A.B., Barefoot, J.C., Williams, R.B., Jr., Costa, P.T., Jr., & McCrae, R. R. (1990). Predicting personality from college MMPI scores: Implications for follow-up studies in psychosomatic medicine. Psychosomatic Medicine, 52, 644-652.

Siegler, I.C., Peterson, B.L., Barefoot, J.C., & Williams, R.B. (1992). Hostility during late adolescence predicts coronary risk factors at midlife. American Journal of Epidemiology, 138(2), 146-154.

Siegler, I.C., Peterson, B.L., Barefoot, J.C., Harvin, S.H. Dahlstrom, W.G., Kaplan, B.H., Costa, P.T. Jr., & Williams, R.B. (1992). Using college alumni populations in epidemiologic research: The UNC Alumni Heart Study. Journal of Clinical Epidemiology, 45(11), 1243-1250.

Siegler, I.C., Dawson, D.V., & Welsh, K.A. (1994). Caregiver ratings of personality change in Alzheimer's disease patients: A replication. Psychology and Aging, 9, 464-466.

Siegler, I.C., Feaganes, J.R., & Rimer, B.K. (1995). Predictors of adoption of mammography in women under age 50. Health Psychology, 14, 274-278.


Iqbal Kring, SI, Barefoot, J, Brummett, BH, Boyle, SH, Siegler, IC, Toubro, S, Hansen, T, Astrup, A, Pedersen, O, Williams, RB, and Sørensen, TIA. "Associations between APOE variants and metabolic traits and the impact of psychological stress. (Published online)" PLoS One 6.1 (January 19, 2011): e15745-. Full Text

Davey, A, Elias, MF, Siegler, IC, Lele, U, Martin, P, Johnson, MA, Hausman, DB, and Poon, LW. "Cognitive function, physical performance, health, and disease: norms from the georgia centenarian study." Exp Aging Res 36.4 (October 2010): 394-425. Full Text

Williams, RB, Surwit, RS, Siegler, IC, Ashley-Koch, AE, Collins, AL, Helms, MJ, Georgiades, A, Boyle, SH, Brummett, BH, Barefoot, JC, Grichnik, K, Stafford-Smith, M, and Kuhn, CM. "Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men." Psychosom Med 72.7 (September 2010): 601-607. Full Text

Siegler, IC, Brummett, BH, Williams, RB, Haney, TL, and Dilworth-Anderson, P. "Caregiving, residence, race, and depressive symptoms." Aging Ment Health 14.7 (September 2010): 771-778. Full Text

Kring, SII, Brummett, BH, Barefoot, J, Garrett, ME, Ashley-Koch, AE, Boyle, SH, Siegler, IC, Sørensen, TIA, and Williams, RB. "Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls." Psychosom Med 72.5 (June 2010): 427-433. Full Text

Brummett, BH, Boyle, SH, Ortel, TL, Becker, RC, Siegler, IC, and Williams, RB. "Associations of depressive symptoms, trait hostility, and gender with C-reactive protein and interleukin-6 response after emotion recall." Psychosom Med 72.4 (May 2010): 333-339. Full Text

Brummett, BH, Boyle, SH, Kuhn, CM, Siegler, IC, and Williams, RB. "Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c." J Psychiatr Res 44.6 (April 2010): 373-377. Full Text

Jonassaint, CR, Boyle, SH, Kuhn, CM, Siegler, IC, Copeland, WE, and Williams, R. "Personality and inflammation: the protective effect of openness to experience." Ethn Dis 20.1 (2010): 11-14.

Arnold, J, Dai, J, Nahapetyan, L, Arte, A, Johnson, MA, Hausman, D, Rodgers, WL, Hensley, R, Martin, P, Macdonald, M, Davey, A, Siegler, IC, Jazwinski, SM, and Poon, LW. "Predicting successful aging in a population-based sample of georgia centenarians." Curr Gerontol Geriatr Res (2010). Full Text

Hooker, K, Hoppmann, C, and Siegler, IC. "Personality: Life span compass for health." Annual Review of Gerontology and Geriatrics 30.1 (2010): 201-232. Full Text