Kathleen Anne Welsh-Bohmer

Professor of Psychiatry and Behavioral Sciences

Education & Training

  • Ph.D., University of Virginia

Overview

Dr. Kathleen Welsh-Bohmer is a Professor of Psychiatry with a secondary appointment in the Department of Neurology. She is also the Chief of the Medical Psychology CPU, the professional home for the over 200 academic psychologists within Duke Medical Center.  

Clinically trained as a neuropsychologist, Dr. Welsh-Bohmer's research activities have been focused around developing effective prevention and treatment strategies to delay the onset of cognitive disorders occurring in later life.  Since 2006 she has directed the Joseph and Kathleen Bryan Alzheimer’s Center in the Department of Neurology, where she leads a large multidisciplinary team focused on discovering the biological basis of Alzheimer’s disease and developing methods to enhance early diagnosis and speed drug discovery.

Currently, she oversees the neuropsychology scientific operations of a Phase III global clinical trial to delay the onset of Alzheimer’s disease entitled the “TOMMORROW” study (Takeda Pharmaceutical Company funded). The methods her team is developing for this study fill an information void and have implications for accelerating global clinical trials in Alzheimer’s disease prevention.

Sims, R, van der Lee, SJ, Naj, AC, Bellenguez, C, Badarinarayan, N, Jakobsdottir, J, Kunkle, BW, Boland, A, Raybould, R, Bis, JC, Martin, ER, Grenier-Boley, B, Heilmann-Heimbach, S, Chouraki, V, Kuzma, AB, Sleegers, K, Vronskaya, M, Ruiz, A, Graham, RR, Olaso, R, Hoffmann, P, Grove, ML, Vardarajan, BN, Hiltunen, M, Nöthen, MM, White, CC, Hamilton-Nelson, KL, Epelbaum, J, Maier, W, Choi, S-H, Beecham, GW, Dulary, C, Herms, S, Smith, AV, Funk, CC, Derbois, C, Forstner, AJ, Ahmad, S, and Li, H et al. "Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease." Nature genetics 49.9 (September 2017): 1373-1384. Full Text

Blumenthal, JA, Smith, PJ, Mabe, S, Hinderliter, A, Welsh-Bohmer, K, Browndyke, JN, Lin, P-H, Kraus, W, Doraiswamy, PM, Burke, J, and Sherwood, A. "Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment." Psychosomatic medicine 79.6 (July 2017): 719-727. Full Text

Jun, GR, Chung, J, Mez, J, Barber, R, Beecham, GW, Bennett, DA, Buxbaum, JD, Byrd, GS, Carrasquillo, MM, Crane, PK, Cruchaga, C, De Jager, P, Ertekin-Taner, N, Evans, D, Fallin, MD, Foroud, TM, Friedland, RP, Goate, AM, Graff-Radford, NR, Hendrie, H, Hall, KS, Hamilton-Nelson, KL, Inzelberg, R, Kamboh, MI, Kauwe, JSK, Kukull, WA, Kunkle, BW, Kuwano, R, Larson, EB, Logue, MW, Manly, JJ, Martin, ER, Montine, TJ, Mukherjee, S, Naj, A, Reiman, EM, Reitz, C, Sherva, R, and St George-Hyslop, PH et al. "Transethnic genome-wide scan identifies novel Alzheimer's disease loci." Alzheimer's & dementia : the journal of the Alzheimer's Association 13.7 (July 2017): 727-738. Full Text

Browndyke, JN, Berger, M, Harshbarger, TB, Smith, PJ, White, W, Bisanar, TL, Alexander, JH, Gaca, JG, Welsh-Bohmer, K, Newman, MF, and Mathew, JP. "Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings." Journal of the American Geriatrics Society 65.1 (January 2017): e6-e12. Full Text Open Access Copy

Lutz, MW, Crenshaw, D, Welsh-Bohmer, KA, Burns, DK, and Roses, AD. "New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics." Current neurology and neuroscience reports 16.5 (May 2016): 48-. (Review) Full Text

Ridge, PG, Hoyt, KB, Boehme, K, Mukherjee, S, Crane, PK, Haines, JL, Mayeux, R, Farrer, LA, Pericak-Vance, MA, Schellenberg, GD, Kauwe, JSK, Adams, PM, Albert, MS, Albin, RL, Apostolova, LG, Arnold, SE, Asthana, S, Atwood, CS, Baldwin, CT, Barber, RC, Barmada, MM, Barnes, LL, Barral, S, Beach, TG, Becker, JT, Beecham, GW, Beekly, D, Bennett, DA, Bigio, EH, Bird, TD, Blacker, D, Boeve, BF, Bowen, JD, Boxer, A, Burke, JR, Burns, JM, Buxbaum, JD, Cairns, NJ, Cantwell, LB, Cao, C, and Carlson, CS et al. "Assessment of the genetic variance of late-onset Alzheimer's disease." Neurobiology of Aging 41 (May 2016): 200.e13-200.e20. Full Text

Weninger, S, Carrillo, MC, Dunn, B, Aisen, PS, Bateman, RJ, Kotz, JD, Langbaum, JB, Mills, SL, Reiman, EM, Sperling, R, Santacruz, AM, Tariot, PN, and Welsh-Bohmer, KA. "Collaboration for Alzheimer's Prevention: Principles to guide data and sample sharing in preclinical Alzheimer's disease trials." Alzheimer's & dementia : the journal of the Alzheimer's Association 12.5 (May 2016): 631-632. Full Text

Perry, DC, Sturm, VE, Peterson, MJ, Pieper, CF, Bullock, T, Boeve, BF, Miller, BL, Guskiewicz, KM, Berger, MS, Kramer, JH, and Welsh-Bohmer, KA. "Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis." Journal of neurosurgery 124.2 (February 2016): 511-526. (Review) Full Text

Foster, CM, Addis, DR, Ford, JH, Kaufer, DI, Burke, JR, Browndyke, JN, Welsh-Bohmer, KA, and Giovanello, KS. "Prefrontal contributions to relational encoding in amnestic mild cognitive impairment." NeuroImage : Clinical 11 (January 15, 2016): 158-166. Full Text Open Access Copy

Lutz, MW, Sundseth, SS, Burns, DK, Saunders, AM, Hayden, KM, Burke, JR, Welsh-Bohmer, KA, and Roses, AD. "A Genetics-based Biomarker Risk Algorithm for Predicting Risk of Alzheimer's Disease." Alzheimer's & dementia (New York, N. Y.) 2.1 (January 2016): 30-44.

Pages

Mackensen, GB, Ti, LK, Phillips-Bute, BG, Mathew, JP, Newman, MF, Grocott, HP, and Neurologic Outcome Research Group (NORG), . "Cerebral embolization during cardiac surgery: impact of aortic atheroma burden." Br J Anaesth 91.5 (November 2003): 656-661.

Swaminathan, M, McCreath, BJ, Phillips-Bute, BG, Newman, MF, Mathew, JP, Smith, PK, Blumenthal, JA, Stafford-Smith, M, and Perioperative Outcomes Research Group, . "Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction." Anesth Analg 95.1 (July 2002): 1-8.

Metabolic Signatures Underlying Vascular Risk Factors for Alzheimer-type Dementias awarded by National Institutes of Health (Co Investigator). 2015 to 2020

Behavioral and Physiology in Aging awarded by National Institutes of Health (Mentor). 2015 to 2020

Impact of Disclosing Amyloid Imaging Results to Cognitively Normal Individuals awarded by Brigham and Women's Hospital (Principal Investigator). 2015 to 2019

White Matter Damage in Subconcussive Blast Exposure awarded by National Institutes of Health (Co Investigator). 2014 to 2019

Decision Making for Cardiovascular Therapy in Adults with Mild Cognitive Impairment awarded by University of Michigan (Principal Investigator). 2016 to 2018

Metabolic Networks and Pathways in Alzheimer's Disease awarded by National Institutes of Health (Co Investigator). 2014 to 2018

Innovating Tablet-Based Cognitive Assessment for CNS Disorders of Aging awarded by NeuroCog Trials (Principal Investigator). 2016 to 2018

Lifestyle, CVD Risk and Cognitive Impairment awarded by National Institutes of Health (Co Investigator). 2011 to 2018

EXERT awarded by University of California - San Diego (Principal Investigator). 2016 to 2018

Bryan ADRC Brain Bank awarded by Cofactor Genomics, Inc. (Principal Investigator). 2016 to 2017

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