Redford B. Williams

Professor of Psychiatry and Behavioral Sciences

Education & Training

  • M.D., Yale University

Overview

My research aims to identify psychosocial factors that are involved in the pathogenesis and course of major medical disorders, to characterize the biobehavioral mechanisms whereby such factors influence disease, and to develop both behavioral and pharmacologic means of preventing or ameliorating the adverse impact of psychosocial factors on health and disease. Specific projects that are currently active include: 1) The influence of hostile personality, social isolation, depression and other psychosocial risk factors upon the development and course of cardiometabolic disease; 2) Biological and genetic mechanisms whereby psychosocial risk factors influence disease development and course; and 3) Behavioral and pharmacologic approaches to ameliorate impact of psychosocial risk factors on disease risk and course.

Sun, JL, Boyle, SH, Samad, Z, Babyak, MA, Wilson, JL, Kuhn, C, Becker, RC, Ortel, TL, Williams, RB, Rogers, JG, O'Connor, CM, Velazquez, EJ, and Jiang, W. "Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients." European journal of preventive cardiology 24.6 (April 2017): 591-599. Full Text

Williams, RB, Bishop, GD, Haberstick, BC, Smolen, A, Brummett, BH, Siegler, IC, Babyak, MA, Zhang, X, Tai, ES, Lee, JJ-M, Tan, M, Teo, YY, Cai, S, Chan, E, Halpern, CT, Whitsel, EA, Bauldry, S, and Harris, KM. "Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence." American heart journal 185 (March 2017): 110-122. Full Text

Feigal, JP, Boyle, SH, Samad, Z, Velazquez, EJ, Wilson, JL, Becker, RC, Williams, RB, Kuhn, CM, Ortel, TL, Rogers, JG, O'Connor, CM, and Jiang, W. "Associations between positive emotional well-being and stress-induced myocardial ischemia: Well-being scores predict exercise-induced ischemia." Journal of psychosomatic research 93 (February 2017): 14-18. Full Text

Williams, RB. "Loneliness and social isolation and increased risk of coronary heart disease and stroke: clinical implications." Heart (British Cardiac Society) 102.24 (December 2016): 2016-. (Letter) Full Text

Haberstick, BC, Boardman, JD, Wagner, B, Smolen, A, Hewitt, JK, Killeya-Jones, LA, Tabor, J, Halpern, CT, Brummett, BH, Williams, RB, Siegler, IC, Hopfer, CJ, and Mullan Harris, K. "Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health)." PloS one 11.3 (January 2016): e0148373-. Full Text

Singh, A, Babyak, MA, Brummett, BH, Jiang, R, Watkins, LL, Barefoot, JC, Kraus, WE, Shah, SH, Siegler, IC, Hauser, ER, and Williams, RB. "Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene." Genetic epidemiology 39.6 (September 2015): 489-497. Full Text

Singh, A, Babyak, MA, Nolan, DK, Brummett, BH, Jiang, R, Siegler, IC, Kraus, WE, Shah, SH, Williams, RB, and Hauser, ER. "Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene." European journal of human genetics : EJHG 23.6 (June 2015): 854-862. Full Text

Boyle, SH, Matson, WR, Velazquez, EJ, Samad, Z, Williams, RB, Sharma, S, Thomas, B, Wilson, JL, O'Connor, C, and Jiang, W. "Metabolomics analysis reveals insights into biochemical mechanisms of mental stress-induced left ventricular dysfunction." Metabolomics : Official journal of the Metabolomic Society 11.3 (June 2015): 571-582. Full Text

Jiang, W, Boyle, SH, Ortel, TL, Samad, Z, Velazquez, EJ, Harrison, RW, Wilson, J, Kuhn, C, Williams, RB, O'Connor, CM, and Becker, RC. "Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study." American heart journal 169.4 (April 2015): 496-507.e1. Full Text

Haberstick, BC, Smolen, A, Williams, RB, Bishop, GD, Foshee, VA, Thornberry, TP, Conger, R, Siegler, IC, Zhang, X, Boardman, JD, Frajzyngier, Z, Stallings, MC, Brent Donnellan, M, Halpern, CT, and Harris, KM. "Population frequencies of the Triallelic 5HTTLPR in six Ethnicially diverse samples from North America, Southeast Asia, and Africa." Behavior genetics 45.2 (March 2015): 255-261. Full Text

Pages

Williams, RB. "Gene by environment interactions: Impact on women’s health." Psychosocial Stress and Cardiovascular Disease in Women: Concepts, Findings, Future Perspectives. January 1, 2015. 151-160. Full Text

Williams, RB. "Hostility, Neuroendocrine Changes, and Health Outcomes." The Link Between Religion and Health: Psychoneuroimmunology and the Faith Factor. April 1, 2010. Full Text

Jiang, R, Babyak, MA, Brummett, BH, Hauser, ER, Singh, A, Siegler, IC, Shah, SH, Haynes, C, Chryst-Ladd, M, and Williams, RB. "Brain-Derived Neurotrophic Factor Val66Met Variants (RS6265) are Associated with Coronary Heart Disease (CHD) Outcomes in a Patient Sample." November 2016.

Singh, A, Hauser, ER, Johnson, JL, Babyak, MA, Brummett, BH, Jiang, R, Slentz, CA, Huffman, KM, Siegler, IC, Williams, RB, and Kraus, WE. "Follow-up of GxE Interactions: EBF1 GxE Association, Synthetic Chronic Psychosocial Stress, and Dropout from a Structured Exercise Program." November 2016.

Brummett, BH, Babyak, MA, Jiang, R, Singh, A, Williams, RB, Harris, KM, and Siegler, IC. "BIOBEHAVIORAL MEDIATORS OF SES EFFECTS ON CRP IN A NATIONALLY REPRESENTATIVE US SAMPLE." April 2013.

Williams, RB, Bishop, GD, Haberstick, BC, Smolen, A, Helms, MJ, Brummett, BH, Siegler, IC, Babyak, MA, Zhang, X, Tai, ES, Lee, JM, Tan, M, Teo, Y-Y, Cai, S, Chan, E, Halpern, CT, Whitsel, EA, Shanahan, MJ, Bauldry, S, and Harris, KM. "POPULATION DIFFERENCES IN ASSOCIATIONS OF SEROTONIN TRANSPORTER PROMOTER POLYMORPHISM (5HTTLPR) DI- AND TRIALLELIC GENOTYPES WITH BLOOD PRESSURE AND HYPERTENSION PREVALENCE." April 2013.

Babyak, MA, Becker, RC, Helms, MJ, Jiang, R, Singh, A, Brummett, BH, Siegler, IC, Ashley-Koch, A, Ortel, T, and Williams, RB. "ADRENERGIC GENE VARIANTS ARE ASSOCIATED WITH PLATELET AGGREGATION TO EPINEPHRINE." April 2013.

Lane, JD, Kuhn, CM, Surwit, RS, Siegler, IC, Brummett, BH, and Williams, RB. "BLOOD PRESSURE 'NON-DIPPING' STATUS IS ASSOCIATED WITH GREATER OVERNIGHT EPINEPHRINE EXCRETION." April 2013.

Georgiades, A, Brummett, BH, Siegler, IC, Surwit, RS, Kuhn, C, Grichnik, K, Stafford-Smith, M, and Williams, RB. "EFFECT OF CENTRAL NERVOUS SYSTEM SEROTONIN FUNCTION ON INFLAMMATION, ADIPOSITY AND INSULIN SENSITIVITY." April 2013.

Bidwell, LC, Garrett, ME, McClernon, FJ, Fuemmeler, BF, Williams, RB, Ashley-Koch, AE, and Kollins, SH. "Genotype and ADHD symptoms interact to predict adolescents' early smoking experiences in an epidemiological sample." November 2011.

Genes, environmental stressors, and the biobehavioral pathways to CVD awarded by National Institutes of Health (Principal Investigator). 1997 to 2021

An Innovative Model to Predict Readmissions in Adults with Cardiovascular Disease awarded by National Institutes of Health (Collaborator). 2013 to 2018

Behavior And Physiology In Aging awarded by National Institutes of Health (Mentor). 1999 to 2015

Responses of Myocardial Ischemia to Sertraline Treatment awarded by National Institutes of Health (Co Investigator). 2006 to 2013

Training in Psychological Intervention Research awarded by National Institutes of Health (Training Faculty). 2006 to 2011

Hostility, Race, and Glucose Metabolism awarded by National Institutes of Health (Mentor). 2003 to 2009

PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health (Consultant). 2002 to 2009

PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health (Consultant). 2002 to 2008

Duke Center for Geospatial Medicine awarded by National Institutes of Health (Investigator). 2004 to 2008

Surveillance And Analysis Of The UNC Alumni Heart Study awarded by National Institutes of Health (Co Investigator). 1996 to 2007

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