Thomas Mark Newpher

Thomas Mark Newpher

Assistant Professor of the Practice of Psychology and Neuroscience

Education & Training

  • Ph.D., Case Western Reserve University School of Medicine 2006

Overview

Dr. Newpher teaches and advises for Duke's Undergraduate Studies in Neuroscience program.  He also directs the Summer Neuroscience Program of Research in the Duke Institute for Brain Sciences.  Dr. Newpher earned his Ph.D. in molecular biology from Case Western Reserve University. He then came to Duke to receive postdoctoral training in the Department of Neurobiology, where his research focused on identifying key molecular mechanisms that underlie learning-related synaptic plasticity.  

As the director of the Summer Neuroscience Program, Dr. Newpher provides mentorship and professional development opportunities for undergraduate research fellows.  Within the Undergraduate Neuroscience program, he instructs several courses, including Cellular and Molecular Neurobiology, Contemporary Neuroscience Methods, Fundamentals of Neuroscience, the Neurobiology of Learning and Memory, and Neuroplasticity and Disease.  His courses utilize a variety of team-based learning activities to promote critical thinking skills, foster collaboration among students, and create an engaging, student-centered classroom experience.  Dr. Newpher’s current research focuses on identifying teaching practices that increase student learning and improve classroom dynamics.

Expertise

synaptic plasticity, learning and memory, neuroscience education, scholarship of teaching and learning

Newpher, TM, Harris, S, Pringle, J, Hamilton, C, and Soderling, S. "Regulation of spine structural plasticity by Arc/Arg3.1." Seminars in Cell & Developmental Biology 77 (May 2018): 25-32. (Review) Full Text

Chi, RJ, Torres, OT, Segarra, VA, Lansley, T, Chang, JS, Newpher, TM, and Lemmon, SK. "Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis." Journal of Cell Science 125.Pt 20 (October 2012): 4728-4739. Full Text Open Access Copy

Grötsch, H, Giblin, JP, Idrissi, F-Z, Fernández-Golbano, I-M, Collette, JR, Newpher, TM, Robles, V, Lemmon, SK, and Geli, M-I. "Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites." The Embo Journal 29.17 (September 2010): 2899-2914. Full Text Open Access Copy

Shaked, NT, Newpher, TM, Ehlers, MD, and Wax, A. "Parallel on-axis holographic phase microscopy of biological cells and unicellular microorganism dynamics." Applied Optics 49.15 (May 2010): 2872-2878. Full Text Open Access Copy

Newpher, TM, and Ehlers, MD. "Spine microdomains for postsynaptic signaling and plasticity." Trends in Cell Biology 19.5 (May 2009): 218-227. (Review) Full Text

Newpher, TM, and Ehlers, MD. "Glutamate receptor dynamics in dendritic microdomains." Neuron 58.4 (May 2008): 472-497. (Review) Full Text

Lu, J, Helton, TD, Blanpied, TA, Rácz, B, Newpher, TM, Weinberg, RJ, and Ehlers, MD. "Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer." Neuron 55.6 (September 2007): 874-889. Full Text

Newpher, TM, Idrissi, F-Z, Geli, MI, and Lemmon, SK. "Novel function of clathrin light chain in promoting endocytic vesicle formation." Molecular Biology of the Cell 17.10 (October 2006): 4343-4352. Full Text

Pages

Newpher, TM, and Lemmon, SK. "Clathrin accumulates with endocytic factors at the cell cortex upon disruption of the actin cytoskeleton in yeast." Annual Meeting of the American-Society-for-Cell-Biology. December 4, 2004 - December 8, 2004. Washington, DC.: AMER SOC CELL BIOLOGY, November 1, 2004.

Selected Grants

The Endocytic Machinery of Dendritic Spines awarded by National Institutes of Health (Research Associate). 2003 to 2011

Regulation of excitatory synapses by local zones of endocytic cycling awarded by National Institutes of Health (PI-Fellow). 2008 to 2011