Terrie E. Moffitt
  • Terrie E. Moffitt

  • Nannerl O. Keohane University Professor
  • Psychology and Neuroscience
  • Phone: (919) 684-5831
  • Fax: (919) 684-5912
  • Homepage
  • Other

    Ute Wittmann Pair
    Avshalom Caspi
    Honalee Harrington
    Renate Houts
    Karen Sugden
    Benjamin Williams
  • Specialties

    • Clinical Psychology
    • Developmental Psychology
  • Research Summary

    developmental psychopathology, behavioral genetics, mental health epidemiology
  • Education

      • Ph.D.,
      • University of Southern California,
      • 1984
      • Postdoctoral Fellowship,
      • Neuropsychiatric Institute, UCLA Medical School,
      • 1984
      • M.A.,
      • University of Southern California,
      • 1981
      • B.A.,
      • University of North Carolina at Chapel Hill,
      • 1977
      • BA, Psychology,
      • University of North Carolina, Chapel Hill,
      • 1977
  • Awards, Honors and Distinctions

      • 2012 Named one of the top 10 Criminologists worldwide,
      • Scholarly Influence in Criminology and Criminal Justice, NY: Nova publishers.,
      • 0 2012
      • Klaus J. Jacobs Research Prize for Productive Youth Development,
      • Jacobs Foundation,
      • December, 2010
      • NARSAD Ruane Prize for Outstanding Achievement in Childhood Psychiatric Disorders,
      • NARSAD,
      • November, 2010
      • Fellowship of King's College London,
      • King's College London,
      • 2010
      • Lady Davis Fellowship,
      • Hebrew University, Jerusalem,
      • 2010
      • Fellow of the Association for Psychological Science,
      • Association for Psychological Science,
      • December, 2009
      • Klaus Grawe Memorial Prize,
      • German Sociaety of Psychology,
      • May, 2009
      • Distiguished Scientific Contribution Award,
      • International Society for the Study of Behavioural Development (ISSBD),
      • December, 2008
      • Rema Lapouse Award,
      • American Public Health Association,
      • December, 2008
      • The Stockholm Prize in Criminology,
      • 2007
      • Thorsten Sellin Fellow,
      • American Academy of Political & Social Science,
      • 2007
      • Division 53 of the American Psychological Association Distinguished Research Contributions Award,
      • 2006
      • Elected to Academia Europaea,
      • 2005
      • Fellow of the American Psychopathological Association,
      • 2005
      • ISI Highly Cited Researcher in Psychiatry/Psychology,
      • 2005
      • Who’s Who in the UK,
      • 2005
      • Fellow,
      • British Academy,
      • 0 2004
      • Fellow of the British Academy,
      • 2004
      • Eleanor Maccoby Book Award,
      • American Psychological Association,
      • 2003
      • Fellow of the American Society of Criminology,
      • 2003
      • Named among the 50 people most influencing Britain’s health,
      • The (London) Times,
      • 2003
      • John P. Hill Memorial Award,
      • Society for Research in Adolescence,
      • 2002
      • Wolfson Research Merit Award,
      • Royal Society,
      • 2002
      • Fellow of the Academy of Medical Sciences,
      • 1999
      • Fellows,
      • Academy of Medical Sciences,
      • 0 1999
      • Kellett Mid-Career Award,
      • University of Wisconsin,
      • 1997
      • Vilas Associate Award,
      • University of Wisconsin,
      • 1994
      • Distinguished Scientific Award for Early Career Contribution to Psychology,
      • American Psychological Association,
      • 1993
      • Distinguished Scientific Awards for Early Career Contributions to Psychology (psychopathology),
      • American Psychological Association,
      • 0 1993
      • H.I. Romnes Faculty Fellow Award,
      • University of Wisconsin,
      • 1992
      • New Investigator Award,
      • National Institute of Mental Health,
      • 1984
      • Graduate Research Fellow,
      • U.S. Department of Justice,
      • 1982
  • Selected Publications

      • L Arseneault, M Cannon, HL Fisher, G Polanczyk, TE Moffitt and A Caspi.
      • 2011.
      • Childhood trauma and children's emerging psychotic symptoms: A genetically sensitive longitudinal cohort study..
      • Am J Psychiatry
      • 168:
      • 65-72
      • .
      Publication Description

      OBJECTIVE: Using longitudinal and prospective measures of trauma during childhood, the authors assessed the risk of developing psychotic symptoms associated with maltreatment, bullying, and accidents in a nationally representative U.K. cohort of young twins. METHOD: Data were from the Environmental Risk Longitudinal Twin Study, which follows 2,232 twin children and their families. Mothers were interviewed during home visits when children were ages 5, 7, 10, and 12 on whether the children had experienced maltreatment by an adult, bullying by peers, or involvement in an accident. At age 12, children were asked about bullying experiences and psychotic symptoms. Children's reports of psychotic symptoms were verified by clinicians. RESULTS: Children who experienced mal-treatment by an adult (relative risk=3.16, 95% CI=1.92-5.19) or bullying by peers (relative risk=2.47, 95% CI=1.74-3.52) were more likely to report psychotic symptoms at age 12 than were children who did not experience such traumatic events. The higher risk for psychotic symptoms was observed whether these events occurred early in life or later in childhood. The risk associated with childhood trauma remained significant in analyses controlling for children's gender, socioeconomic deprivation, and IQ; for children's early symptoms of internalizing or externalizing problems; and for children's genetic liability to developing psychosis. In contrast, the risk associated with accidents was small (relative risk=1.47, 95% CI=1.02-2.13) and inconsistent across ages. CONCLUSIONS: Trauma characterized by intention to harm is associated with children's reports of psychotic symptoms. Clinicians working with children who report early symptoms of psychosis should inquire about traumatic events such as maltreatment and bullying.

      • DW Belsky, A Caspi, L Arseneault, W Bleidorn, P Fonagy, M Goodman, R Houts and TE Moffitt.
      • 2012.
      • Etiological features of borderline personality related characteristics in a birth cohort of 12-year-old children..
      • Dev Psychopathol
      • 24:
      • 251-265
      • .
      Publication Description

      It has been reported that borderline personality related characteristics can be observed in children, and that these characteristics are associated with increased risk for the development of borderline personality disorder. It is not clear whether borderline personality related characteristics in children share etiological features with adult borderline personality disorder. We investigated the etiology of borderline personality related characteristics in a longitudinal cohort study of 1,116 pairs of same-sex twins followed from birth through age 12 years. Borderline personality related characteristics measured at age 12 years were highly heritable, were more common in children who had exhibited poor cognitive function, impulsivity, and more behavioral and emotional problems at age 5 years, and co-occurred with symptoms of conduct disorder, depression, anxiety, and psychosis. Exposure to harsh treatment in the family environment through age 10 years predicted borderline personality related characteristics at age 12 years. This association showed evidence of environmental mediation and was stronger among children with a family history of psychiatric illness, consistent with diathesis-stress models of borderline etiology. Results indicate that borderline personality related characteristics in children share etiological features with borderline personality disorder in adults and suggest that inherited and environmental risk factors make independent and interactive contributions to borderline etiology.

      • Bowes, L., Maughan, B., Ball, H., Shakoor, S., Ouellet-Morin, I., Caspi, A., Moffitt, T.E., & Arseneault, L..
      • 2013.
      • Chronic bullying victimization across school transitions: The role of genetic and environmental influences.
      • Development and Psychopathology
      • 25:
      • 333-346
      • .
      Publication Description

      We investigated the antecedents and consequences of chronic victimization by bullies across a school transition using a genetically sensitive longitudinal design. Data were from the Environmental Risk Longitudinal Twin Study (E-Risk), an epidemiological cohort of 2,232 children. We used mothers' and children's reports of bullying victimization during primary school and early secondary school. Children who experienced frequent victimization at both time points were classed as "chronic victims" and were found to have an increased risk for mental health problems and academic difficulties compared to children who were bullied only in primary school, children bullied for the first time in secondary school, and never-bullied children. Biometric analyses revealed that stability in victimization over this period was influenced primarily by genetic and shared environmental factors. Regression analyses showed that children's early characteristics such as preexistent adjustment difficulties and IQ predicted chronic versus transitory victimization. Family risk factors for chronic victimization included socioeconomic disadvantage, low maternal warmth, and maltreatment. Our results suggest that bullying intervention programs should consider the role of the victims' behaviors and family background in increasing vulnerability to chronic victimization. Our study highlights the importance of widening antibullying interventions to include families to reduce the likelihood of children entering a pathway toward chronic victimization.

      • A Danese, A Caspi, B Williams, A Ambler, K Sugden, J Mika, H Werts, J Freeman, CM Pariante, TE Moffitt and L Arseneault.
      • 2011.
      • Biological embedding of stress through inflammation processes in childhood..
      • Mol Psychiatry
      • 16:
      • 244-246
      • .
      • NMG Fontaine, EJP McCrory, M Boivin, TE Moffitt and E Viding.
      • 2011.
      • Predictors and Outcomes of Joint Trajectories of Callous-Unemotional Traits and Conduct Problems in Childhood.
      • Journal of Abnormal Psychology
      • 120:
      • 730-742
      • .
      Publication Description

      Callous-unemotional (CU) traits are associated with antisocial and delinquent behaviors in children and represent a potential risk factor for adult psychopathy. However, there is a paucity of longitudinal research that explores the development of these traits, their longitudinal association with conduct problems (CP), and their psychosocial predictors and outcomes. Using a large sample of children followed longitudinally from the Twins Early Development Study (N = 9,578), we described the joint developmental trajectories of CU traits and CP during childhood (between ages 7 and 12) and examined the child- and family-level predictors (4 years old) and concomitant outcomes (12 years old) associated with the trajectories. The developmental trajectories were characterized with teachers' ratings of CU traits and CP from ages 7 to 12. Using general growth mixture modeling, we identified four trajectories of CU traits (stable high, increasing, decreasing, and stable low) and two trajectories of CP (high and low). Compared with the children who followed a low trajectory of CU traits and CP, those who followed a high trajectory of CU traits and CP had more negative child- and family-level predictors at 4 years (including CP, hyperactivity, negative parental discipline, and chaos in the home). Children with high or increasing levels of CU traits and concomitant high levels of CP presented the most negative outcomes at 12 years (including hyperactivity, peer problems, emotional problems, and negative parental feelings). Children with high CU traits and concomitant high levels of CP in childhood should be prioritized for targeted intervention. © 2011 American Psychological Association.

      • AM Gregory, TE Moffitt, A Ambler, L Arseneault, RM Houts and A Caspi.
      • 2012.
      • Maternal insomnia and children's family socialization environments..
      • Sleep
      • 35:
      • 579-582
      • .
      Publication Description

      STUDY OBJECTIVES: To examine concurrent associations between maternal insomnia and different aspects of the family socialization environment. DESIGN: Mothers reported on their symptoms of insomnia in a private standardized interview and interviewers evaluated the family socialization environment using the Coder's Inventory. SETTING: Assessments were conducted in participants' homes within the U.K. PATIENTS OR PARTICIPANTS: One thousand one hundred sixteen mothers of British children enrolled in the Environmental Risk (E-Risk) study were invited to participate when their children were aged 12 years. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: After controlling for family socioeconomic status (SES), mothers' relationship status, and maternal depression, maternal insomnia was associated with a poorer family socialization environment (β = -0.10, [95% confidence intervals (CI) = -0.16, -0.04], P

      • JR Grisham, MA Fullana, D Mataix Cols, TE Moffitt, A Caspi and R Poulton.
      • 2011.
      • Childhood risk factors associated with adult obsessive-compulsive symptoms and obsessive-compulsive disorder.
      • Psychological Medicine
      • .
      • DR Lynam, R Charnigo, TE Moffitt, A Raine, R Loeber and M Stouthamer-Loeber.
      • 2009.
      • The stability of psychopathy across adolescence.
      • Development and Psychopathology
      • 21:
      • 1133-1153
      • .
      Publication Description

      The current diagnostic system suggests that personality disorder categories be applied to children and adolescents in rare circumstances because of expected changes in personality pathology across development. The present study examined the stability in personality pathology, specifically psychopathy, across childhood and adolescence. Using a short form of the CPS and mixed models incorporating fixed and random effects, we examined the reliability, individual stability, mean-level stability, and predictive utility of juvenile psychopathy as a function of age (i.e., from 7 to 17 years old) in over 1,500 boys from the three cohorts of the Pittsburgh Youth Study. If adolescent development contributes to instability in personality pathology, large age-related fluctuations in reliability, stability, and predictive utility should be observed, particularly in the latter part of adolescence when normative changes are hypothesized to influence levels of psychopathy. Such fluctuations were not observed. In general, juvenile psychopathy could be reliably assessed beginning in childhood, was fairly stable across short and long intervals, showed little mean-level fluctuation, and predicted delinquency across adolescence. These results suggest that concerns about large changes in personality pathology across childhood and adolescence may be overstated. Implications and future directions are discussed. © 2009 Cambridge University Press.

      • TE Moffitt, L Arseneault, D Belsky, N Dickson, RJ Hancox, H Harrington, R Houts, R Poulton, BW Roberts, S Ross, MR Sears, WM Thomson and A Caspi.
      • 2011.
      • A gradient of childhood self-control predicts health, wealth, and public safety..
      • Proc Natl Acad Sci U S A
      • 108:
      • 2693-2698
      • .
      Publication Description

      Policy-makers are considering large-scale programs aimed at self-control to improve citizens' health and wealth and reduce crime. Experimental and economic studies suggest such programs could reap benefits. Yet, is self-control important for the health, wealth, and public safety of the population? Following a cohort of 1,000 children from birth to the age of 32 y, we show that childhood self-control predicts physical health, substance dependence, personal finances, and criminal offending outcomes, following a gradient of self-control. Effects of children's self-control could be disentangled from their intelligence and social class as well as from mistakes they made as adolescents. In another cohort of 500 sibling-pairs, the sibling with lower self-control had poorer outcomes, despite shared family background. Interventions addressing self-control might reduce a panoply of societal costs, save taxpayers money, and promote prosperity.

      • Ouellet-Morin, I., Danese, A., Bowes, L., Shakoor, S., Ambler, A., Pariante, C., Papadopoulos, A., Caspi, A Moffitt, T.E., & Arseneault, L..
      • 2011.
      • A discordant MZ twin design shows blunted cortisol reactivity among bullied children.
      • Journal of the American Academy of Child and Adolescent Psychiatry
      • 50:
      • 574-582
      • .
      • I Ouellet-Morin, CL Odgers, A Danese, L Bowes, S Shakoor, AS Papadopoulos, A Caspi, TE Moffitt and L Arseneault.
      • 2011.
      • Blunted cortisol responses to stress signal social and behavioral problems among maltreated/bullied 12-year-old children..
      • Biol Psychiatry
      • 70:
      • 1016-1023
      • .
      Publication Description

      BACKGROUND: Evidence from animal and human studies suggests that early-life stress such as physical maltreatment has long-lasting effects on the hypothalamic-pituitary-adrenal (HPA) axis and is associated with blunted HPA axis reactivity in adulthood. Few studies have investigated whether blunted HPA axis reactivity observed in children exposed to early-life stress signals social, emotional, and behavioral problems. METHODS: Participants were 190 12-year-old children (50.5% males) recruited from the Environmental Risk Longitudinal Twin Study, a nationally representative 1994 to 1995 cohort of families with twins. Cortisol responses to psychosocial stress were measured in maltreated/bullied (n = 64) and comparison children (n = 126). We ascertained maltreatment and bullying victimization using mothers' reports and assessed children's social, emotional, and behavioral problems at ages 5 and 12 using mothers' and teachers' reports. RESULTS: Piecewise multilevel growth curve analyses indicated that maltreated/bullied and comparison children showed distinct cortisol responses to stress. Specifically, maltreated/bullied children had lower cortisol responses than comparison children who exhibited a significant increase. Lower cortisol responses were, in turn, associated with more social and behavioral problems among maltreated/bullied children. CONCLUSIONS: These findings provide support for the influence of childhood harm on blunted HPA axis reactivity and its potential impact on children's functioning. Our findings emphasize the need to integrate stress biomarkers in guiding prevention efforts for young victims.

      • S Shakoor, SR Jaffee, L Bowes, I Ouellet-Morin, P Andreou, F Happé, TE Moffitt and L Arseneault.
      • 2012.
      • A prospective longitudinal study of children's theory of mind and adolescent involvement in bullying.
      • Journal of Child Psychology and Psychiatry and Allied Disciplines
      • 53:
      • 254-261
      • .
      Publication Description

      Background: Theory of mind (ToM) allows the understanding and prediction of other people's behaviours based on their mental states (e.g. beliefs). It is important for healthy social relationships and thus may contribute towards children's involvement in bullying. The present study investigated whether children involved in bullying during early adolescence had poor ToM in childhood. Method: Participants were members of the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally representative sample of 2,232 children and their families. We visited families when children were 5, 7, 10 and 12 years. ToM was assessed when the children were 5 years using eight standardized tasks. Identification of those children who were involved in bullying as victims, bullies and bully-victims using mothers', teachers' and children's reports was carried out when they were 12 years' old. Results: Poor ToM predicted becoming a victim (effect size, d = 0.26), bully (d = 0.25) or bully-victim (d = 0.44) in early adolescence. These associations remained for victims and bully-victims when child-specific (e.g. IQ) and family factors (e.g. child maltreatment) were controlled for. Emotional and behavioural problems during middle childhood did not modify the association between poor ToM and adolescent bullying experiences. Conclusion: Identifying and supporting children with poor ToM early in life could help reduce their vulnerability for involvement in bullying and thus limit its adverse effects on mental health. © 2011 Association for Child and Adolescent Mental Health.

      • S Shakoor, SR Jaffee, P Andreou, L Bowes, AP Ambler, A Caspi, TE Moffitt and L Arseneault.
      • 2011.
      • Mothers and children as informants of bullying victimization: results from an epidemiological cohort of children..
      • J Abnorm Child Psychol
      • 39:
      • 379-387
      • .
      Publication Description

      Stressful events early in life can affect children's mental health problems. Collecting valid and reliable information about children's bad experiences is important for research and clinical purposes. This study aimed to (1) investigate whether mothers and children provide valid reports of bullying victimization, (2) examine the inter-rater reliability between the two informants, (3) test the predictive validity of their reports with children's emotional and behavioral problems and (4) compare the genetic and environmental etiology of bullying victimization as reported by mothers and children. We assessed bullying victimization in the Environmental-Risk (E-Risk) Longitudinal Twin Study, a nationally-representative sample of 1,116 families with twins. We collected reports from mothers and children during private interviews, including detailed narratives. Findings showed that we can rely on mothers and children as informants of bullying victimization: both informants provided information which adhered to the definition of bullying as involving repeated hurtful actions between peers in the presence of a power imbalance. Although mothers and children modestly agreed with each other about who was bullied during primary and secondary school, reports of bullying victimization from both informants were similarly associated with children's emotional and behavioral problems and provided similar estimates of genetic and environmental influences. Findings from this study suggest that collecting information from multiple informants is ideal to capture all instances of bullying victimization. However, in the absence of child self-reports, mothers can be considered as a viable alternative, and vice versa.

      • Shearer, DM, Thomson, WM, Caspi, A, Moffitt, TE, Poulton R..
      • 2011.
      • Family history and oral health: findings from the Dunedin Family History Study.
      • Community Dentistry and Oral Epidemiology
      • .
      • DM Shearer, WM Thomson, A Caspi, TE Moffitt, JM Broadbent and R Poulton.
      • 2011.
      • Inter-generational continuity in periodontal health: findings from the Dunedin family history study..
      • J Clin Periodontol
      • 38:
      • 301-309
      • .
      Publication Description

      OBJECTIVE: To determine whether parental periodontal disease history is a risk factor for periodontal disease in adult offspring. METHODS: Proband periodontal examination [combined attachment loss (CAL) at age 32, and incidence of CAL from ages 26 to 32] and interview data were collected during the age-32 assessments in the Dunedin Study. Parental data were also collected. The sample was divided into two familial-risk groups for periodontal disease (high- and low-risk) based on parents' self-reported periodontal disease. RESULTS: Periodontal risk analysis involved 625 proband-parent(s) groups. After controlling for confounding factors, the high-familial-risk periodontal group was more likely to have 1+ sites with 4+mm CAL [relative risk (RR) 1.45; 95% confidence interval (CI) 1.11-1.88], 2+ sites with 4+mm CAL (RR 1.45; 95% CI 1.03-2.05), 1+ sites with 5+mm CAL (RR 1.60; 95% CI 1.02-2.50), and 1+ sites with 3+mm incident CAL (RR 1.64; 95% CI 1.01-2.66) than the low-familial-risk group. Predictive validity was enhanced when information was available from both parents. CONCLUSIONS: Parents with poor periodontal health tend to have offspring with poor periodontal health. Family/parental history of oral health is a valid representation of the shared genetic and environmental factors that contribute to an individual's periodontal status, and may help to predict patient prognosis and preventive treatment need.

      • W Slutske, TE Moffitt, R Poulton and A Caspi.
      • 2012.
      • Under-controlled child temperament predicts adult problem gambling.
      • Psychological Science
      • 23:
      • 510-516
      • .
      Publication Description

      Using data from the large, 30-year prospective Dunedin cohort study, we examined whether preexisting individual differences in childhood temperament predicted adulthood disordered gambling (a diagnosis covering the full continuum of gambling-related problems). A 90-min observational assessment at age 3 was used to categorize children into five temperament groups, including one primarily characterized by behavioral and emotional undercontrol. The children with undercontrolled temperament at 3 years of age were more than twice as likely to evidence disordered gambling at ages 21 and 32 than were children who were well-adjusted at age 3. These associations could not be explained by differences in childhood IQ or family socioeconomic status. Cleanly demonstrating the temporal relation between behavioral undercontrol and adult disordered gambling is an important step toward building more developmentally sensitive theories of disordered gambling and may put researchers in a better position to begin considering potential routes to disordered-gambling prevention through enhancing self-control and emotional regulation.

      • WM Thomson, A Caspi, R Poulton, TE Moffitt and JM Broadbent.
      • 2011.
      • Personality and oral health..
      • Eur J Oral Sci
      • 119:
      • 366-372
      • .
      Publication Description

      We investigated age-26 personality characteristics and age-32 oral health in a prospective study of a complete birth cohort born in Dunedin, New Zealand. Personality was measured using the Multidimensional Personality Questionnaire (MPQ). Oral health was measured using the short-form Oral Health Impact Profile (OHIP-14), a global measure, and dental examinations. Personality profiles were constructed for 916 individuals (50.8% men) using standardized MPQ scores, and multivariate analyses examined their association with oral health. Those reporting 1+ OHIP-14 impacts had higher Negative Emotionality scores (and lower Constraint and Positive Emotionality MPQ superfactor scores) than those who did not. After controlling for gender, clinical status, and the other two MPQ superfactors, those scoring higher on Negative Emotionality had a greater risk of reporting 1+ OHIP-14 impacts, as well as 3+ OHIP-14 impacts and worse-than-average oral health. They also had a greater risk of having lost at least one tooth from caries and of having 3+ decayed surfaces. Personality characteristics appear to shape self-reports of oral health. Personality is also a risk factor for clinical disease status, at least with respect to dental caries and its sequelae. Because the attitudes and values tapped into by personality tests can be altered by brief cognitive interventions, those might be useful in preventive dentistry.

      • R Uher, A Caspi, R Houts, K Sugden, B Williams, R Poulton and TE Moffitt.
      • 2011.
      • Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results..
      • J Affect Disord
      • 135:
      • 56-65
      • .
      Publication Description

      BACKGROUND: Genetic and environmental factors shape life-long vulnerability to depression, but most gene-environment interaction (G×E) research has focused on cross-sectional assessments rather than life-course phenotypes. This study tests the hypothesis that the G×E involving the length polymorphism in the serotonin-transporter-gene-linked-promoter-region (5-HTTLPR) and childhood maltreatment is specific to depression that runs a persistent course in adulthood. METHODS: The hypothesis is tested in two cohorts. Men and women in the Dunedin Study (N=847), New Zealand, followed to age 32 years with 96% retention and women in the E-Risk Study (N=930), England, followed to age 40 years with 96% retention. Diagnoses of past-year major depressive episode were established at four separate assessments. Depression diagnosed on two or more occasions was considered persistent. RESULTS: In both cohorts, statistical tests of gene-environment interactions showed positive results for persistent depression but not single-episode depression. Individuals with two short 5-HTTLPR alleles and childhood maltreatment had elevated risk of persistent but not single-episode depression. LIMITATIONS: Some cases of recurrent depression may have been misclassified as single-episode due to non-contiguous assessment windows, but this would have a conservative effect on the findings. Chronic and recurrent depression could not be reliably distinguished due to non-contiguous periods of assessment. Therefore, the term persistent depression is used to describe either chronic or recurrent course. CONCLUSIONS: The specific effect on persistent depression increases the significance of this G×E for public health. Research that does not distinguish persistent course may underestimate G×E effects and account for some replication failures in G×E research.

      • P Zimmermann, T Brückl, A Nocon, H Pfister, EB Binder, M Uhr, R Lieb, TE Moffitt, A Caspi, F Holsboer and M Ising.
      • 2011.
      • Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study..
      • Am J Psychiatry
      • 168:
      • 1107-1116
      • .
      Publication Description

      OBJECTIVE: The binding protein FKBP5 is an important modulator of the function of the glucocorticoid receptor, the main receptor of the stress hormone system. This turns the FKBP5 gene into a key candidate for gene-environment interactions, which are considered critical for pathogenesis of stress-related disorders. The authors explored gene-environment interactions between FKBP5 gene variants and adverse life events in predicting the first occurrence of a major depressive episode. METHOD: The analyses were based on 884 Caucasians in a 10-year prospective community study. At baseline, they were 14-24 years old and did not fulfill criteria for a major depressive episode. The DSM-IV-based Munich Composite International Diagnostic Interview was used to assess adverse life events preceding baseline and major depressive episodes during follow-up. On the basis of previous findings, five single-nucleotide polymorphisms (SNPs) within the FKBP5 gene were selected for genotyping. RESULTS: While the authors did not observe genetic main effects, they found interactions between the five SNPs and traumatic (but not separation) events, with the strongest effect for severe trauma. The effect of trauma on incident major depressive episodes was evident among subjects homozygous for the minor alleles but not subjects with other genotypes. The findings were replicated in the U.K. Environmental Risk Longitudinal Twin Study. CONCLUSIONS: These hypothesis-driven results suggest that an interaction between FKBP5 genotype and trauma is involved in the onset of depression. Subjects homozygous for the minor alleles of the investigated FKBP5 SNPs seem to be particularly sensitive to effects of trauma exposure in terms of triggering depression onset.

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  • Postdoctoral Students

    • Daniel Belsky
      • 2012 - present
    • Salomon Israel
      • 2012 - present
    • Sidra Goldman-Mellor
      • 2012 - present
    • Michael Pluess
      • 2012 - present
    • Argyris Stringaris
      • 2011 - present
    • Helen Fisher
      • 2011 - present
    • Idan Shalev
      • 2011 - present
    • Madeline Meier
      • 2010 - 2012
    • Guilherme Polanczyk
      • 2008 - 2010
      • University of Sao Paolo
    • Karen Sugden
      • 2011
    • Maria Melchior
      • 2006 - 2007
      • Senior Researcher, INSERM France.
    • Alice Gregory
      • 2005 - 2006
      • Lecturer, Goldsmith’s College, University of London.
    • Candice Odgers
      • 2005 - 2007
      • Assistant Professor, University of California at Irvine. 2007 American Psychological Assn. Law and Psychology Early Career Award.
    • Kali Trzesniewski
      • 2003 - 2005
      • Assistant Professor, University of Western Ontario.
    • Jon Mill
      • 2003 - 2004
      • Postdoctoral Research Fellow, University of Toronto, Lecturer Institute of Psychiatry, UK.
    • Julia Kim-Cohen
      • 2002 - 2005
      • Assistant Professor, Yale University.
    • Sara Jaffee
      • 2001 - 2003
      • Assistant Professor, University of Pennsylvania
    • Louise Arseneault
      • 1998 - 2001
      • Senior Lecturer Institute of Psychiatry, UK and Senior Research Fellow, Canadian Institute of Health Research.
    • Richard Miech
      • 1997
      • Associate Professor of Public Health, Johns Hopkins University.
    • Brad E. Wright
      • 1996 - 1998
      • Associate Professor of Sociology, University of Connecticut.
    • Lynn Magdol
      • 1995 - 1996
      • Assistant Professor of Sociology, SUNY, Buffalo. (not tenured)
    • Denise Newman
      • 1995 - 1996
      • Associate Professor of Psychology, Tulane University.
  • Teaching

    • PSY 754S.01
      • Soc/Psych 237
      • M 04:40 PM-07:10 PM