Study of the origins of clinically-relevant electrical signals, such as EEG, ECG, or EMG. Generation of biopotentials by active cells, fibers, and tissues. Transmission of biopotentials to the measuring electrodes through intervening tissues; effects of inhomogeneities and anisotropy. Students develop models of biopotentials and learn numerical and mathematical tools for solving and analyzing these models. Laboratory exercises based on computer simulations, with emphasis on quantitative behavior. Readings from original literature. Prerequisite: BME 301L or consent of the instructor.