“Cholinergic Representation Of Movement In The Sensorimotor Striatum”

Cholinergic interneurons (CINs) have been implicated in diverse behaviors, ranging from movement modulation to cognitive flexibility. To understand how CINs support these functions, we monitored the acetylcholine release and CIN activity in behaving mice. We observed the cholinergic activity consistently tracks ongoing movement across contexts, independent of learning or motivational valence. This cholinergic representation of movement suggests a potential mechanism for movement modulation and adaptation.