Andrew Sherwood

Andrew Sherwood

Professor in Psychiatry and Behavioral Sciences

Education & Training

  • Ph.D., University of Hull (England) 1972

Overview

My current research focus is on biological, behavioral and sociocultural factors involved in the etiology and management of hypertension, coronary artery disease, and congestive heart failure. The role of stress and the sympathetic nervous system in disease onset and progression is of central interest. Current research issues being studied include: (i) Ethnicity and gender as factors related to the pathogenesis of hypertension; (ii) Mechanisms by which menopause increases the risk of cardiovascular disease in women; (iii) Mechanisms by which stress may provoke episodes of myocardial ischemia in patients with coronary artery disease; (iv) Stress biomarkers that are associated with adverse clinical outcomes in cardiac patients; (v) The development of coping skills interventions to improve prognosis and quality of life in patients with congestive heart failure; (vi) Circadian blood pressure profiles for risk stratification in patients with hypertension; (vii) Biological and behavioral factors contributing to elevated nighttime blood pressure and blunted nighttime blood pressure dipping.

Comprehensive assessments of cardiovascular regulatory systems define the daily activity in the biobehavioral research laboratory. Assessments include: (i) hemodynamic (blood pressure, cardiac output, systemic vascular resistance) and neurohumoral responses (plasma epinephrine and norepinephrine) during psychological and physical stress testing; (ii) alpha and beta adrenergic receptor function, the baroreceptor reflex, and cardiac vagal control; (iii) endothelial function, and vascular structure and compliance; (iv) left ventricular structure and function by echocardiography; (v) 24-hour ambulatory blood pressure and cardiac output monitoring; (vi) Nonivasive assessments of arterial stiffness and central aortic pressure; (vii) Psychometric assessments of personality and lifestyle characteristics related to cardiovascular disease.

A secondary research interest is in the use and development of noninvasive techniques for evaluating the cardiovascular system. Developments include an ambulatory impedance cardiography system, permitting assessment of 24-hour hemodynamics during normal daily activities, and biomarkers of cardiovascular risk obtained using ultrasound imaging.

RESINT.DOC 1/5/99

Smith, PJ, Blumenthal, JA, Hinderliter, AL, Watkins, LL, Hoffman, BM, and Sherwood, A. "Microvascular Endothelial Function and Neurocognition Among Adults With Major Depressive Disorder." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry 26.10 (October 2018): 1061-1069. Full Text

Hess, TM, Growney, CM, O'Brien, EL, Neupert, SD, and Sherwood, A. "The role of cognitive costs, attitudes about aging, and intrinsic motivation in predicting engagement in everyday activities." Psychology and Aging 33.6 (September 2018): 953-964. Full Text

Smith, PJ, Sherwood, A, and Blumenthal, JA. "Effects of aerobic exercise on white matter hyperintensities: An exploratory analysis." General Hospital Psychiatry 53 (July 2018): 84-85. (Letter) Full Text

Blumenthal, JA, Sherwood, A, Smith, PJ, and Hinderliter, A. "The Role of Salt Reduction in the Management of Hypertension." Journal of the American College of Cardiology 71.14 (April 2018): 1597-1598. Full Text

Sherwood, A, Ulmer, CS, and Beckham, JC. "Waking up to the importance of sleeping well for cardiovascular health." Journal of clinical hypertension (Greenwich, Conn.) 20.3 (March 2018): 606-608. Full Text

Sherwood, A, Hill, LK, Blumenthal, JA, and Hinderliter, AL. "Circadian hemodynamics in men and women with high blood pressure: dipper vs. nondipper and racial differences." Journal of hypertension 36.2 (February 2018): 250-258. Full Text

Hill, LK, Sherwood, A, McNeilly, M, Anderson, NB, Blumenthal, JA, and Hinderliter, AL. "Impact of Racial Discrimination and Hostility on Adrenergic Receptor Responsiveness in African American Adults." Psychosomatic Medicine 80.2 (February 2018): 208-215. Full Text

Blumenthal, JA, and Sherwood, A. "Missing ingredients for a lifestyle recipe to treat hypertension." Journal of Thoracic Disease 10.2 (February 2018): 653-656. Full Text

Smith, PJ, Sherwood, A, Mabe, S, Watkins, L, Hinderliter, A, and Blumenthal, JA. "Physical activity and psychosocial function following cardiac rehabilitation: One-year follow-up of the ENHANCED study." General Hospital Psychiatry 49 (November 2017): 32-36. Full Text

Tyson, CC, Smith, PJ, Sherwood, A, Mabe, S, Hinderliter, AL, and Blumenthal, JA. "Association between normal or mildly reduced kidney function, cardiovascular risk and biomarkers for atherosclerosis: results from the ENCORE trial." Clinical kidney journal 10.5 (October 2017): 666-671. Full Text

Pages

Lett, HS, Sherwood, A, Watkins, L, and Blumenthal, JA. "Depression and prognosis in cardiac patients." Depression and Physical Illness. January 1, 2006. 87-108. Full Text

Hill, L, Sherwood, A, Blumenthal, J, and Hinderliter, A. "SYNERGISTIC IMPACT OF PERCEIVED DISCRIMINATION AND HOSTILITY ON ADRENERGIC RESPONSIVITY." 57th Annual Meeting of the Society-for-Psychophysiological-Research. October 11, 2017 - October 15, 2017. Vienna, AUSTRIA.: WILEY, December 1, 2017.

Dillavou, E, Turley, R, Nag, U, Sherwood, A, Lucas, J, Gardner, E, and Roza, A. "VESS27. Alternative Access for Fistula Cannulation in the Obese: Midterm Results from VWING Registry." June 2017. Full Text

Hill, LK, Sherwood, A, Blumenthal, JA, and Hinderliter, AL. "SYNERGISTIC IMPACT OF PERCEIVED DISCRIMINATION AND HOSTILITY ON ADRENERGIC RESPONSIVITY." May 2017.

Smith, PJ, Blumenthal, JA, Hinderliter, AL, and Sherwood, A. "OBESITY IS ASSOCIATED WITH POORER NEUROCOGNITIVE PERFORMANCE AMONG ADULTS WITH HIGH BLOOD PRESSURE." April 2013.

Watkins, LL, Sherwood, A, Blumenthal, JA, Smith, PJ, Geordiades, A, and Jr, SMH. "NATURALISTIC STRESSORS ARE ASSOCIATED WITH REDUCED 24-HOUR HRV IN ACUTE POST-MI PATIENTS." April 2013.

Green, KT, Calhoun, PS, Dennis, MF, Sherwood, A, Allen, R, Oddone, A, and Beckham, JC. "THE EVALUATION OF A CARDIOVASCULAR BIOMARKER AND ANGER EXPRESSION IN INDIVIDUALS WITH AND WITHOUT POSTTRAUMATIC STRESS DISORDER (PTSD)." March 2013.

Oddone, AE, Calhoun, PS, Stein, J, Dennis, MF, Sherwood, A, Watkins, LL, Allen, RK, Fulton, JJ, Dennis, P, and Beckham, JC. "BASELINE AND POSTURE-RELATED DIFFERENCES IN BLOOD PRESSURE AMONG YOUNGER INDIVIDUALS WITH AND WITHOUT POSTTRAUMATIC STRESS DISORDER." March 2013.

Bacon, SL, Sherwood, A, Hinderliter, A, Babyak, M, Waugh, R, Georgiades, A, Coleman, RE, and Blumenthal, JA. "The effects of exercise training on mental stress-induced ischemia." 2006.

Pages

Selected Grants

The Effect of Reducing Posttraumatic Stress Disorder Symptoms on Cardiovascular Risk awarded by National Institutes of Health (Co Investigator). 2016 to 2021

Exercise and Pharmacotherapy for Anxiety in Cardiac Patients awarded by National Institutes of Health (Co Investigator). 2015 to 2020

Neurocognition, Lifestyle Modification, and Treatment Resistant Hypertension awarded by National Institutes of Health (Co Investigator). 2016 to 2019

Facility and Web-based Approaches to Lifestyle Change in Resistant Hypertension awarded by National Institutes of Health (Co-Principal Investigator). 2014 to 2019

Depression and Heart Failure Disease Progression awarded by National Institutes of Health (Principal Investigator). 2014 to 2019

Social Cognition and Aging awarded by North Carolina State University (Principal Investigator). 2015 to 2019

Lifestyle, CVD Risk and Cognitive Impairment awarded by National Institutes of Health (Co Investigator). 2011 to 2018

Stress Management and Biomarkers of Risk in Cardiac Rehabilitation awarded by National Institutes of Health (Co Investigator). 2009 to 2016

Hostility, PTSD and Physical Health Risk Factors awarded by National Institutes of Health (Co Investigator). 2009 to 2015

Ancillary Investigation of Mental Stress Biomarkers in Coronary Heart Disease awarded by National Institutes of Health (Principal Investigator). 2010 to 2015

Pages