David Joseph Madden

David Joseph Madden

Professor of Medical Psychology in the Department of Psychiatry and Behavioral Sciences

Education & Training

  • Ph.D., University of California at Davis 1977


My research focuses primarily on the cognitive neuroscience of aging: the investigation of age-related changes in perception, attention, and memory, using both behavioral measures and neuroimaging techniques, including positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and diffusion tensor imaging (DTI).

The behavioral measures have focused on reaction time, with the goal of distinguishing age-related changes in specific cognitive abilities from more general effects arising from a slowing in elementary perceptual processes. The cognitive abilities of interest include selective attention as measured in visual search tasks, semantic and episodic memory retrieval, and executive control processes.

The behavioral measures are necessary to define the cognitive abilities of interest, and the neuroimaging techniques help define the functional neuroanatomy of those abilities. The PET and fMRI measures provide information regarding neural activity during cognitive performance. DTI is a recently developed technique that images the structural integrity of white matter. The white matter tracts of the brain provide critical pathways linking the gray matter regions, and thus this work will complement the studies using PET and fMRI that focus on gray matter activation.

A current focus of the research program is the functional connectivity among regions, not only during cognitive task performance but also during rest. These latter measures, referred to as intrinsic functional connectivity, are beginning to show promise as an index of overall brain functional efficiency, which can be assessed without the implementation of a specific cognitive task. From DTI, information can be obtained regarding how anatomical connectivity constrains intrinsic functional connectivity. It will be important to determine the relative influence of white matter pathway integrity, intrinsic functional connectivity, and task-related functional connectivity, as mediators of age-related differences in behavioral measures of cognitive performance.

Ultimately, the research program can help link age-related changes in cognitive performance to changes in the structure and function of specific neural systems. The results also have implications for clinical translation, in terms of the identification of neural biomarkers for the diagnosis of neural pathology and targeting rehabilitation procedures.

Diaz, MT, Johnson, MA, Burke, DM, Truong, T-K, and Madden, DJ. "Age-related differences in the neural bases of phonological and semantic processes in the context of task-irrelevant information." Cognitive, Affective & Behavioral Neuroscience (November 28, 2018). Full Text

Zhuang, J, Madden, DJ, Duong-Fernandez, X, Chen, N-K, Cousins, SW, Potter, GG, Diaz, MT, and Whitson, HE. "Language processing in age-related macular degeneration associated with unique functional connectivity signatures in the right hemisphere." Neurobiology of Aging 63 (March 2018): 65-74. Full Text Open Access Copy

Monge, ZA, Geib, BR, Siciliano, RE, Packard, LE, Tallman, CW, and Madden, DJ. "Functional modular architecture underlying attentional control in aging." Neuroimage 155 (July 2017): 257-270. Full Text

Cordero, DM, Towe, SL, Chen, N-K, Robertson, KR, Madden, DJ, Huettel, SA, and Meade, CS. "Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection." Journal of neurovirology 23.3 (June 2017): 441-450. Full Text

Siciliano, RE, Madden, DJ, Tallman, CW, Boylan, MA, Kirste, I, Monge, ZA, Packard, LE, Potter, GG, and Wang, L. "Task difficulty modulates brain activation in the emotional oddball task." Brain research 1664 (June 2017): 74-86. Full Text Open Access Copy

Madden, DJ, Parks, EL, Tallman, CW, Boylan, MA, Hoagey, DA, Cocjin, SB, Packard, LE, Johnson, MA, Chou, Y-H, Potter, GG, Chen, N-K, Siciliano, RE, Monge, ZA, Honig, JA, and Diaz, MT. "Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume." Neurobiology of Aging 54 (June 2017): 199-213. Full Text Open Access Copy

Madden, DJ, Parks, EL, Tallman, CW, Boylan, MA, Hoagey, DA, Cocjin, SB, Johnson, MA, Chou, Y-H, Potter, GG, Chen, N-K, Packard, LE, Siciliano, RE, Monge, ZA, and Diaz, MT. "Frontoparietal activation during visual conjunction search: Effects of bottom-up guidance and adult age." Human Brain Mapping 38.4 (April 2017): 2128-2149. Full Text Open Access Copy

Chou, Y-H, Sundman, M, Whitson, HE, Gaur, P, Chu, M-L, Weingarten, CP, Madden, DJ, Wang, L, Kirste, I, Joliot, M, Diaz, MT, Li, Y-J, Song, AW, and Chen, N-K. "Maintenance and Representation of Mind Wandering during Resting-State fMRI." Scientific Reports 7 (January 12, 2017): 40722-null. Full Text

Zhuang, J, Johnson, MA, Madden, DJ, Burke, DM, and Diaz, MT. "Age-related differences in resolving semantic and phonological competition during receptive language tasks." Neuropsychologia 93.Pt A (December 2016): 189-199. Full Text

Monge, ZA, and Madden, DJ. "Linking cognitive and visual perceptual decline in healthy aging: The information degradation hypothesis." Neuroscience and Biobehavioral Reviews 69 (October 2016): 166-173. (Review) Full Text Open Access Copy


Salthouse, TA, and Madden, DJ. "Information processing speed and aging." Information Processing Speed in Clinical Populations. January 1, 2007. 221-241. Full Text

Madden, DJ, Whiting, WL, and Huettel, SA. "Age-related changes in neural activity during visual perception and attention." Cognitive Neuroscience of Aging: Linking cognitive and cerebral aging. May 1, 2005. Full Text

Madden, DJ, and Parks, EL. "Age differences in structural connectivity: Diffusion tensor imaging and white matter hyperintensities." Cognitive neuroscience of aging: Linking cognitive and cerebral aging (2nd Ed.). Trans. R Cabeza, L Nyberg, and DC Park.

Selected Grants

Neuroimaging of Visual Attention in Aging awarded by National Institutes of Health (Principal Investigator). 2011 to 2023

Neurobehavioral Mechanisms of Emotion Regulation in Depression across the Adult Lifespan awarded by National Institutes of Health (Co Investigator). 2017 to 2022

Quantitative Susceptibility Mapping of Iron Accumulation in Neurocognitive Aging awarded by National Institutes of Health (Principal Investigator). 2017 to 2019

Neuroimaging of Age-Related Changes in Language awarded by Pennsylvania State University (Principal Investigator). 2017 to 2019

Cognitive Changes and Brain Connectivity in Age-Related Macular Degeneration awarded by National Institutes of Health (Co Investigator). 2013 to 2019

Imaging of Intrinsic Connectivity Networks awarded by National Institutes of Health (Co Investigator). 2011 to 2018

Dorsal Cingulate Activity and Cognitive Decline in Late-Life Depression awarded by National Institutes of Health (Principal Investigator). 2012 to 2018

Effects of Aging on Visual Memory: Neuroimaging Studies awarded by National Institutes of Health (Co Investigator). 2001 to 2018

A Compute Cluster for Brain Imaging and Analysis awarded by National Institutes of Health (Major User). 2016 to 2017

Neural Substrates Associated with Executive Functioning in Marijuana and HIV awarded by National Institutes of Health (Investigator). 2014 to 2016