Francis Joseph Keefe

Francis Joseph Keefe

Professor in Psychiatry and Behavioral Sciences

Education & Training

  • Ph.D., Ohio State University 1975

  • M.S., Ohio State University 1973

  • B.A., Bowdoin College 1971


The primary aim of our research over the past year has been to evaluate the efficacy of cognitive-behavioral treatments for arthritis pain. We are conducting two treatment outcome studies supported by grants from the National Institute of Arthritis, Musculoskeletal, and Skin Diseases. The first project, conducted with osteoarthritis patients, seeks to determine whether aerobic exercise training can enhance the effects of a cognitive behavior therapy (CBT) intervention for managing pain and disability. The CBT intervention is innovative in that it systematically involves spouses in training in pain coping skills. The second project, tests the long-term effectiveness of a relapse prevention training intervention. This study will feature the use of newly developed daily study methods to analyze the long-term effects of pain coping skills training on daily pain.

In addition, in conjunction with Lara Schanberg of the Department of Medicine we are carrying out a study funded by the Arthritis Foundation that examines the effects of a pain coping skills training regimen for pediatric fibromyalgia patients.

Finally, we are currently gathering pilot data for two new research projects. One project seeks to evaluate the efficacy of a cognitive behavior theapy and education intervention for managing pain in patients having breast cancer and prostate cancer. The second project examines the efficacy of patient controlled compression protocol in the management of pain during mammography.

Winger, Joseph G., et al. “Predictors of Intervention Session Completion in a Randomized Clinical Trial of a Behavioral Cancer Pain Intervention.J Pain Symptom Manage, vol. 59, no. 6, June 2020, pp. 1268–77. Pubmed, doi:10.1016/j.jpainsymman.2020.01.020. Full Text

Eccleston, Christopher, et al. “Managing patients with chronic pain during the COVID-19 outbreak: considerations for the rapid introduction of remotely supported (eHealth) pain management services.Pain, vol. 161, no. 5, May 2020, pp. 889–93. Pubmed, doi:10.1097/j.pain.0000000000001885. Full Text

Shelby, Rebecca A., et al. “Improving health engagement and lifestyle management for breast cancer survivors with diabetes.Contemp Clin Trials, vol. 92, May 2020, p. 105998. Pubmed, doi:10.1016/j.cct.2020.105998. Full Text

Bennell, Kim L., et al. “Better Knee, Better Me™: effectiveness of two scalable health care interventions supporting self-management for knee osteoarthritis - protocol for a randomized controlled trial.Bmc Musculoskelet Disord, vol. 21, no. 1, Mar. 2020, p. 160. Pubmed, doi:10.1186/s12891-020-3166-z. Full Text

Winger, Joseph G., et al. “Enhancing meaning in the face of advanced cancer and pain: Qualitative evaluation of a meaning-centered psychosocial pain management intervention.Palliat Support Care, Mar. 2020, pp. 1–8. Pubmed, doi:10.1017/S1478951520000115. Full Text

Blumenthal, James A., et al. “Remote Therapy to Improve Outcomes in Lung Transplant Recipients: Design of the INSPIRE-III Randomized Clinical Trial.Transplant Direct, vol. 6, no. 3, Mar. 2020, p. e535. Pubmed, doi:10.1097/TXD.0000000000000979. Full Text

Plumb Vilardaga, Jennifer C., et al. “Coping Skills Training and Acceptance and Commitment Therapy for Symptom Management: Feasibility and Acceptability of a Brief Telephone-Delivered Protocol for Patients With Advanced Cancer.J Pain Symptom Manage, vol. 59, no. 2, Feb. 2020, pp. 270–78. Pubmed, doi:10.1016/j.jpainsymman.2019.09.005. Full Text

Garland, Eric L., et al. “Mind-Body Therapies for Opioid-Treated Pain: A Systematic Review and Meta-analysis.Jama Intern Med, Nov. 2019. Pubmed, doi:10.1001/jamainternmed.2019.4917. Full Text

Porter, Laura S., et al. “Feasibility of a mindful yoga program for women with metastatic breast cancer: results of a randomized pilot study.Support Care Cancer, vol. 27, no. 11, Nov. 2019, pp. 4307–16. Pubmed, doi:10.1007/s00520-019-04710-7. Full Text

Winger, Joseph G., et al. “Indices of pain variability: a paradigm shift.Pain, vol. 160, no. 11, Nov. 2019, pp. 2411–12. Pubmed, doi:10.1097/j.pain.0000000000001627. Full Text


Keefe, F. J. Foreword. 2016, pp. xi–xiii. Scopus, doi:10.1016/B978012800538506001-5. Full Text

Somers, T. J., et al. “Dealing with cancer pain: Coping, pain catastrophizing, and related outcomes.” Cancer Pain: From Molecules to Suffering, 2015.

Lester, N., et al. “Coping with chronic pain.” Cambridge Handbook of Psychology, Health and Medicine, Second Edition, 2014, pp. 50–55. Scopus, doi:10.1017/CBO9780511543579.012. Full Text

Waters, S. J., et al. “Pain assessment.” Cambridge Handbook of Psychology, Health and Medicine, Second Edition, 2014, pp. 300–04. Scopus, doi:10.1017/CBO9780511543579.065. Full Text

Naylor, M. R., et al. “Pain imaging.” Handbook of Pain and Palliative Care: Biobehavioral Approaches for the Life Course, 2013, pp. 439–67. Scopus, doi:10.1007/978-1-4419-1651-8_27. Full Text

Keefe, F. J., et al. “Psychological interventions for cancer pain.” Cancer Pain: Assessment and Management, Second Edition, 2009, pp. 343–53. Scopus, doi:10.1017/CBO9780511642357.019. Full Text

Keefe, F. J. “Acute pain: A psychosocial perspective.” Acute Pain Management, 2009, pp. 41–52. Scopus, doi:10.1017/CBO9780511576706.005. Full Text

Zimmaro, Lauren A., et al. “Greater mindfulness associated with lower pain, fatigue, and psychological distress in women with metastatic breast cancer.Psychooncology, vol. 29, no. 2, 2020, pp. 263–70. Pubmed, doi:10.1002/pon.5223. Full Text

Musey, Paul I., et al. “Gender differences in acute and chronic pain in the emergency department: results of the 2014 Academic Emergency Medicine consensus conference pain section.Acad Emerg Med, vol. 21, no. 12, 2014, pp. 1421–30. Pubmed, doi:10.1111/acem.12529. Full Text

Selected Grants

Couple Communication Skills Training for Advanced Cancer awarded by National Institutes of Health (Co Investigator). 2020 to 2024

Improving Symptom Management for Survivors of Young Adult Cancer awarded by National Institutes of Health (Collaborator). 2019 to 2024

Duke Roybal Center awarded by National Institutes of Health (Co-Principal Investigator). 2019 to 2024

Duke Pain Early-phase Research Clinical Center (PERC) awarded by National Institutes of Health (Co-Principal Investigator). 2019 to 2024

Improving Lung Transplant Outcomes with Coping Skills and Physical Activity awarded by National Institutes of Health (Co Investigator). 2019 to 2024

AIM BACK UH3 Transition awarded by National Institutes of Health (Investigator). 2017 to 2024

Improving Adherence to Adjuvant Endocrine Therapy in Breast Cancer Patients awarded by National Institutes of Health (Co Investigator). 2016 to 2021

Optimizing Delivery of a Behavioral Cancer Pain Intervention Using a SMART awarded by National Institutes of Health (Co Investigator). 2016 to 2021