Henry Yin

Henry Yin

Professor of Psychology and Neuroscience and Director of Graduate Studies

Education & Training

  • Ph.D., University of California - Los Angeles 2004

Overview

I am interested in understanding the neural mechanisms underlying goal-directed actions. For the first time in history, advances in psychology and neurobiology have made it feasible to pursue the detailed neural mechanisms underlying goal-directed and voluntary actions--how they are driven by the needs and desires of the organism and controlled by cognitive processes that provide a rich representation of the self and the world. My approach to this problem is highly integrative, combining behavioral analysis with electrophysiological techniques as well as tools from molecular biology. In the near future three techniques will be emphasized. 1) Dissecting reward-guided behavior using analytical behavioral assays. 2) In vivo recording from cerebral cortex, thalamus, midbrain, and basal ganglia in awake behaving rodents. Up to hundreds of neurons can be recorded from multiple brain areas that form a functional neural network in a single animal. 3) In vitro (and ex vivo) whole-cell patch-clamp recording in brain slices, with the aid of genetic tools for visualization of distinct neuronal populations. Ultimately, I hope to characterize goal-directed actions at multiple levels of analysis--from molecules to neural networks. This knowledge will provide us with insight into various pathological conditions characterized by impaired goal-directed behaviors, such as drug addiction, obsessive-compulsive disorder, Parkinson's disease, and Huntington's disease.

Expertise

Reward, action, goal, learning, habit, basal ganglia, brain, motivation

Rossi, Mark A., et al. “A wirelessly controlled implantable LED system for deep brain optogenetic stimulation.Frontiers in Integrative Neuroscience, vol. 9, Jan. 2015, p. 8. Epmc, doi:10.3389/fnint.2015.00008. Full Text Open Access Copy

Kim, Namsoo, et al. “Striatal firing rate reflects head movement velocity.The European Journal of Neuroscience, vol. 40, no. 10, Nov. 2014, pp. 3481–90. Epmc, doi:10.1111/ejn.12722. Full Text

McKinstry, Spencer U., et al. “Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.J Neurosci, vol. 34, no. 28, July 2014, pp. 9455–72. Pubmed, doi:10.1523/JNEUROSCI.4699-13.2014. Full Text Open Access Copy

Barter, Joseph W., et al. “The role of the substantia nigra in posture control.The European Journal of Neuroscience, vol. 39, no. 9, May 2014, pp. 1465–73. Epmc, doi:10.1111/ejn.12540. Full Text

Leblond, Mona, et al. “The role of pedunculopontine nucleus in choice behavior under risk.The European Journal of Neuroscience, vol. 39, no. 10, May 2014, pp. 1664–70. Epmc, doi:10.1111/ejn.12529. Full Text

Yin, Henry H. “Action, time and the basal ganglia.Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 369, no. 1637, Mar. 2014, p. 20120473. Epmc, doi:10.1098/rstb.2012.0473. Full Text

Hayrapetyan, Volodya, et al. “Region-specific impairments in striatal synaptic transmission and impaired instrumental learning in a mouse model of Angelman syndrome.The European Journal of Neuroscience, vol. 39, no. 6, Mar. 2014, pp. 1018–25. Epmc, doi:10.1111/ejn.12442. Full Text

Yin, H. H. Cortico-Basal Ganglia Networks and the Neural Substrates of Actions. Jan. 2014, pp. 29–47. Scopus, doi:10.1016/B978-0-12-405941-2.00002-X. Full Text

Leblond, M., et al. “The role of pedunculopontine nucleus in choice behavior under risk.” European Journal of Neuroscience, 2014.

Barter, J. W., et al. “The role of the substantia nigra in posture control.” European Journal of Neuroscience, 2014.

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