Ilene C. Siegler

Ilene C. Siegler

Professor in Psychiatry and Behavioral Sciences

Education & Training

  • M.P.H., University of North Carolina at Chapel Hill 1988

  • Ph.D., Syracuse University 1973


My research efforts are in the area of developmental health psychology and organized around understanding the role of personality in health and disease in middle and later life.

My primary research activity is as Principal Investigator of the UNC Alumni Heart Study (UNCAHS) a prospective epidemiologic study of 5000 middle aged men and women and 1200 of their spounses that evaluates the role of personality on coronary heart disease and coronary heart disease risk, cancer and normal aging.

As head of Cancer Prevention Research Unit , I study the role of psychological factors related to mammography behavior and estrogen replacement therapy is being studied in UNCAHS women.


Siegler, I.C., Zonderman, A.B., Barefoot, J.C., Williams, R.B., Jr., Costa, P.T., Jr., & McCrae, R. R. (1990). Predicting personality from college MMPI scores: Implications for follow-up studies in psychosomatic medicine. Psychosomatic Medicine, 52, 644-652.

Siegler, I.C., Peterson, B.L., Barefoot, J.C., & Williams, R.B. (1992). Hostility during late adolescence predicts coronary risk factors at midlife. American Journal of Epidemiology, 138(2), 146-154.

Siegler, I.C., Peterson, B.L., Barefoot, J.C., Harvin, S.H. Dahlstrom, W.G., Kaplan, B.H., Costa, P.T. Jr., & Williams, R.B. (1992). Using college alumni populations in epidemiologic research: The UNC Alumni Heart Study. Journal of Clinical Epidemiology, 45(11), 1243-1250.

Siegler, I.C., Dawson, D.V., & Welsh, K.A. (1994). Caregiver ratings of personality change in Alzheimer's disease patients: A replication. Psychology and Aging, 9, 464-466.

Siegler, I.C., Feaganes, J.R., & Rimer, B.K. (1995). Predictors of adoption of mammography in women under age 50. Health Psychology, 14, 274-278.


Do, EK, Haberstick, BC, Williams, RB, Lessem, JM, Smolen, A, Siegler, IC, and Fuemmeler, BF. "The role of genetic and environmental influences on the association between childhood ADHD symptoms and BMI." International Journal of Obesity (2005) 43.1 (January 2019): 33-42. Full Text

Boyle, SH, Brummett, BH, Kuhn, CM, Barefoot, JC, Siegler, IC, Williams, RB, and Georgiades, A. "The Effects of Tryptophan Enhancement and Depletion on Plasma Catecholamine Levels in Healthy Individuals." Psychosomatic Medicine 81.1 (January 2019): 34-40. Full Text

Singh, A, Babyak, MA, Brummett, BH, Kraus, WE, Siegler, IC, Hauser, ER, and Williams, RB. "Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses." Bmc Research Notes 11.1 (July 24, 2018): 504-null. Full Text

Lewis, LS, Huffman, KM, Smith, IJ, Donahue, MP, Slentz, CA, Houmard, JA, Hubal, MJ, Hoffman, EP, Hauser, ER, Siegler, IC, and Kraus, WE. "Genetic Variation in Acid Ceramidase Predicts Non-completion of an Exercise Intervention." Frontiers in Physiology 9 (January 2018): 781-null. Full Text

Brummett, BH, Babyak, MA, Singh, A, Hauser, ER, Jiang, R, Huffman, KM, Kraus, WE, Shah, SH, Siegler, IC, and Williams, RB. "Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies." Frontiers in Genetics 9 (January 2018): 423-null. Full Text

Ogle, CM, Siegler, IC, Beckham, JC, and Rubin, DC. "Neuroticism Increases PTSD Symptom Severity by Amplifying the Emotionality, Rehearsal, and Centrality of Trauma Memories." Journal of Personality 85.5 (October 2017): 702-715. Full Text

Jiang, R, Babyak, MA, Brummett, BH, Hauser, ER, Shah, SH, Becker, RC, Siegler, IC, Singh, A, Haynes, C, Chryst-Ladd, M, Craig, DM, and Williams, RB. "Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort." American Heart Journal 190 (August 2017): 40-45. Full Text

Jiang, R, Babyak, MA, Brummett, BH, Siegler, IC, Kuhn, CM, and Williams, RB. "Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress." Psychoneuroendocrinology 79 (May 2017): 13-19. Full Text

Williams, RB, Bishop, GD, Haberstick, BC, Smolen, A, Brummett, BH, Siegler, IC, Babyak, MA, Zhang, X, Tai, ES, Lee, JJ-M, Tan, M, Teo, YY, Cai, S, Chan, E, Halpern, CT, Whitsel, EA, Bauldry, S, and Harris, KM. "Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence." American heart journal 185 (March 2017): 110-122. Full Text

Ogle, CM, Rubin, DC, and Siegler, IC. "Commentary-Pre- and Posttrauma Predictors of Posttraumatic Stress Disorder Symptom Severity: Reply to van der Velden and van der Knaap (2017)." Clinical psychological science : a journal of the Association for Psychological Science 5.1 (January 2017): 146-149. Full Text


Selected Grants

Behavioral and Physiology in Aging awarded by National Institutes of Health (Mentor). 2015 to 2020

A Model of Autobiographical Memory & Its Changes in PTSD awarded by National Institutes of Health (Senior Investigator). 2002 to 2016

Behavior And Physiology In Aging awarded by National Institutes of Health (Mentor). 1999 to 2015

Stress and Behavior in Health and Disease awarded by National Institutes of Health (Mentor). 1989 to 2011

Hostililty, Depression, Social Environment, and CHD Risk awarded by National Institutes of Health (Co Investigator). 1997 to 2009

Hostility, Race, and Glucose Metabolism awarded by National Institutes of Health (Co Investigator). 2003 to 2009

Surveillance And Analysis Of The UNC Alumni Heart Study awarded by National Institutes of Health (Principal Investigator). 1996 to 2007

Stress, Serotonin Genes, & Health Disparities awarded by National Institute of Environmental Health Science (Co-Principal Investigator). 2000 to 2006

Improving Cancer Risk Comunication awarded by National Institutes of Health (Principal Investigator). 1996 to 2003

Models of Personality, Health and Disease awarded by National Institutes of Health (Principal Investigator). 1995 to 2001