Ilene C. Siegler

Ilene C. Siegler

Professor in Psychiatry and Behavioral Sciences

Education & Training

  • M.P.H., University of North Carolina at Chapel Hill 1988

  • Ph.D., Syracuse University 1973


My research efforts are in the area of developmental health psychology and organized around understanding the role of personality in health and disease in middle and later life.

My primary research activity is as Principal Investigator of the UNC Alumni Heart Study (UNCAHS) a prospective epidemiologic study of 5000 middle aged men and women and 1200 of their spounses that evaluates the role of personality on coronary heart disease and coronary heart disease risk, cancer and normal aging.

As head of Cancer Prevention Research Unit , I study the role of psychological factors related to mammography behavior and estrogen replacement therapy is being studied in UNCAHS women.


Siegler, I.C., Zonderman, A.B., Barefoot, J.C., Williams, R.B., Jr., Costa, P.T., Jr., & McCrae, R. R. (1990). Predicting personality from college MMPI scores: Implications for follow-up studies in psychosomatic medicine. Psychosomatic Medicine, 52, 644-652.

Siegler, I.C., Peterson, B.L., Barefoot, J.C., & Williams, R.B. (1992). Hostility during late adolescence predicts coronary risk factors at midlife. American Journal of Epidemiology, 138(2), 146-154.

Siegler, I.C., Peterson, B.L., Barefoot, J.C., Harvin, S.H. Dahlstrom, W.G., Kaplan, B.H., Costa, P.T. Jr., & Williams, R.B. (1992). Using college alumni populations in epidemiologic research: The UNC Alumni Heart Study. Journal of Clinical Epidemiology, 45(11), 1243-1250.

Siegler, I.C., Dawson, D.V., & Welsh, K.A. (1994). Caregiver ratings of personality change in Alzheimer's disease patients: A replication. Psychology and Aging, 9, 464-466.

Siegler, I.C., Feaganes, J.R., & Rimer, B.K. (1995). Predictors of adoption of mammography in women under age 50. Health Psychology, 14, 274-278.


Brummett, BH, Boyle, SH, Siegler, IC, Kuhn, CM, Surwit, RS, Garrett, ME, Collins, A, Ashley-Koch, A, and Williams, RB. "HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR)." Biol Psychol 79.2 (October 2008): 250-255. Full Text

Brummett, BH, Muller, CL, Collins, AL, Boyle, SH, Kuhn, CM, Siegler, IC, Williams, RB, and Ashley-Koch, A. "5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion." Behav Genet 38.5 (September 2008): 476-483. Full Text

Brummett, BH, Boyle, SH, Kuhn, CM, Siegler, IC, and Williams, RB. "Associations among central nervous system serotonergic function and neuroticism are moderated by gender." Biol Psychol 78.2 (May 2008): 200-203. Full Text

Brummett, BH, Boyle, SH, Siegler, IC, Zuchner, S, Ashley-Koch, A, and Williams, RB. "Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR)." Med Sci Monit 14.2 (February 2008): CR57-CR61.

Williams, RB, Marchuk, DA, Siegler, IC, Barefoot, JC, Helms, MJ, Brummett, BH, Surwit, RS, Lane, JD, Kuhn, CM, Gadde, KM, Ashley-Koch, A, Svenson, IK, and Schanberg, SM. "Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress." Psychosom Med 70.1 (January 2008): 32-39. Full Text

Brummett, BH, Boyle, SH, Siegler, IC, Kuhn, CM, Ashley-Koch, A, Jonassaint, CR, Züchner, S, Collins, A, and Williams, RB. "Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR)." Behavior Genetics 38.1 (January 2008): 34-43. Full Text

Brummett, BH, Siegler, IC, Day, RS, and Costa, PT. "Personality as a predictor of dietary quality in spouses during midlife." Behavioral Medicine (Washington, D.C.) 34.1 (January 2008): 5-10. Full Text

Richman, LS, Bennett, GG, Pek, J, Siegler, I, and Williams, RB. "Discrimination, dispositions, and cardiovascular responses to stress." Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association 26.6 (November 2007): 675-683. Full Text

Brummett, BH, Krystal, AD, Ashley-Koch, A, Kuhn, CM, Züchner, S, Siegler, IC, Barefoot, JC, Ballard, EL, Gwyther, LP, and Williams, RB. "Sleep quality varies as a function of 5-HTTLPR genotype and stress." Psychosomatic Medicine 69.7 (September 2007): 621-624. Full Text

Brummett, BH, Krystal, AD, Siegler, IC, Kuhn, C, Surwit, RS, Züchner, S, Ashley-Koch, A, Barefoot, JC, and Williams, RB. "Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality." Psychosomatic Medicine 69.5 (June 2007): 396-401. Full Text