Ilene C. Siegler

Ilene C. Siegler

Professor in Psychiatry and Behavioral Sciences

Education & Training

  • M.P.H., University of North Carolina at Chapel Hill 1988

  • Ph.D., Syracuse University 1973


My research efforts are in the area of developmental health psychology and organized around understanding the role of personality in health and disease in middle and later life.

My primary research activity is as Principal Investigator of the UNC Alumni Heart Study (UNCAHS) a prospective epidemiologic study of 5000 middle aged men and women and 1200 of their spounses that evaluates the role of personality on coronary heart disease and coronary heart disease risk, cancer and normal aging.

As head of Cancer Prevention Research Unit , I study the role of psychological factors related to mammography behavior and estrogen replacement therapy is being studied in UNCAHS women.


Siegler, I.C., Zonderman, A.B., Barefoot, J.C., Williams, R.B., Jr., Costa, P.T., Jr., & McCrae, R. R. (1990). Predicting personality from college MMPI scores: Implications for follow-up studies in psychosomatic medicine. Psychosomatic Medicine, 52, 644-652.

Siegler, I.C., Peterson, B.L., Barefoot, J.C., & Williams, R.B. (1992). Hostility during late adolescence predicts coronary risk factors at midlife. American Journal of Epidemiology, 138(2), 146-154.

Siegler, I.C., Peterson, B.L., Barefoot, J.C., Harvin, S.H. Dahlstrom, W.G., Kaplan, B.H., Costa, P.T. Jr., & Williams, R.B. (1992). Using college alumni populations in epidemiologic research: The UNC Alumni Heart Study. Journal of Clinical Epidemiology, 45(11), 1243-1250.

Siegler, I.C., Dawson, D.V., & Welsh, K.A. (1994). Caregiver ratings of personality change in Alzheimer's disease patients: A replication. Psychology and Aging, 9, 464-466.

Siegler, I.C., Feaganes, J.R., & Rimer, B.K. (1995). Predictors of adoption of mammography in women under age 50. Health Psychology, 14, 274-278.


Barefoot, JC, Brummett, BH, Williams, RB, Siegler, IC, Helms, MJ, Boyle, SH, Clapp-Channing, NE, and Mark, DB. "Recovery expectations and long-term prognosis of patients with coronary heart disease." Archives of Internal Medicine 171.10 (May 2011): 929-935. Full Text

Brummett, BH, Siegler, IC, Ashley-Koch, A, and Williams, RB. "Effects of 5HTTLPR on cardiovascular response to an emotional stressor." Psychosomatic Medicine 73.4 (May 2011): 318-322. Full Text

Margrett, JA, Daugherty, K, Martin, P, MacDonald, M, Davey, A, Woodard, JL, Miller, LS, Siegler, IC, and Poon, LW. "Affect and loneliness among centenarians and the oldest old: the role of individual and social resources." Aging & Mental Health 15.3 (April 2011): 385-396. Full Text

Jonassaint, CR, Siegler, IC, Barefoot, JC, Edwards, CL, and Williams, RB. "Low life course socioeconomic status (SES) is associated with negative NEO PI-R personality patterns." Int J Behav Med 18.1 (March 2011): 13-21. Full Text

Iqbal Kring, SI, Barefoot, J, Brummett, BH, Boyle, SH, Siegler, IC, Toubro, S, Hansen, T, Astrup, A, Pedersen, O, Williams, RB, and Sørensen, TIA. "Associations between APOE variants and metabolic traits and the impact of psychological stress. (Published online)" PLoS One 6.1 (January 19, 2011): e15745-. Full Text

Davey, A, Elias, MF, Siegler, IC, Lele, U, Martin, P, Johnson, MA, Hausman, DB, and Poon, LW. "Cognitive function, physical performance, health, and disease: norms from the georgia centenarian study." Experimental Aging Research 36.4 (October 2010): 394-425. Full Text

Williams, RB, Surwit, RS, Siegler, IC, Ashley-Koch, AE, Collins, AL, Helms, MJ, Georgiades, A, Boyle, SH, Brummett, BH, Barefoot, JC, Grichnik, K, Stafford-Smith, M, and Kuhn, CM. "Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men." Psychosomatic Medicine 72.7 (September 2010): 601-607. Full Text

Siegler, IC, Brummett, BH, Williams, RB, Haney, TL, and Dilworth-Anderson, P. "Caregiving, residence, race, and depressive symptoms." Aging & Mental Health 14.7 (September 2010): 771-778. Full Text

Kring, SII, Brummett, BH, Barefoot, J, Garrett, ME, Ashley-Koch, AE, Boyle, SH, Siegler, IC, Sørensen, TIA, and Williams, RB. "Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls." Psychosomatic Medicine 72.5 (June 2010): 427-433. Full Text

Brummett, BH, Boyle, SH, Ortel, TL, Becker, RC, Siegler, IC, and Williams, RB. "Associations of depressive symptoms, trait hostility, and gender with C-reactive protein and interleukin-6 response after emotion recall." Psychosomatic Medicine 72.4 (May 2010): 333-339. Full Text