Kathleen Anne Welsh-Bohmer

Kathleen Anne Welsh-Bohmer

Professor of Psychiatry and Behavioral Sciences

Education & Training

  • Ph.D., University of Virginia 1985

Overview

Dr. Kathleen Welsh-Bohmer is a Professor of Psychiatry with a secondary appointment in the Department of Neurology. She is also the Chief of the Medical Psychology CPU, the professional home for the over 200 academic psychologists within Duke Medical Center.  

Clinically trained as a neuropsychologist, Dr. Welsh-Bohmer's research activities have been focused around developing effective prevention and treatment strategies to delay the onset of cognitive disorders occurring in later life.  Since 2006 she has directed the Joseph and Kathleen Bryan Alzheimer’s Center in the Department of Neurology, where she leads a large multidisciplinary team focused on discovering the biological basis of Alzheimer’s disease and developing methods to enhance early diagnosis and speed drug discovery.

Currently, she oversees the neuropsychology scientific operations of a Phase III global clinical trial to delay the onset of Alzheimer’s disease entitled the “TOMMORROW” study (Takeda Pharmaceutical Company funded). The methods her team is developing for this study fill an information void and have implications for accelerating global clinical trials in Alzheimer’s disease prevention.

Hohman, TJ, Dumitrescu, L, Barnes, LL, Thambisetty, M, Beecham, G, Kunkle, B, Gifford, KA, Bush, WS, Chibnik, LB, Mukherjee, S, De Jager, PL, Kukull, W, Crane, PK, Resnick, SM, Keene, CD, Montine, TJ, Schellenberg, GD, Haines, JL, Zetterberg, H, Blennow, K, Larson, EB, Johnson, SC, Albert, M, Bennett, DA, Schneider, JA, Jefferson, AL, and Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative, . "Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau." Jama Neurology 75.8 (August 2018): 989-998. Full Text

Browndyke, JN, Berger, M, Smith, PJ, Harshbarger, TB, Monge, ZA, Panchal, V, Bisanar, TL, Glower, DD, Alexander, JH, Cabeza, R, Welsh-Bohmer, K, Newman, MF, Mathew, JP, and Duke Neurologic Outcomes Research Group (NORG), . "Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults." Human Brain Mapping 39.2 (February 2018): 985-1003. Full Text Open Access Copy

Weintraub, S, Carrillo, MC, Farias, ST, Goldberg, TE, Hendrix, JA, Jaeger, J, Knopman, DS, Langbaum, JB, Park, DC, Ropacki, MT, Sikkes, SAM, Welsh-Bohmer, KA, Bain, LJ, Brashear, R, Budur, K, Graf, A, Martenyi, F, Storck, MS, and Randolph, C. "Measuring cognition and function in the preclinical stage of Alzheimer's disease." Alzheimer's and Dementia: Translational Research and Clinical Interventions 4 (January 1, 2018): 64-75. Full Text

Weintraub, S, Besser, L, Dodge, HH, Teylan, M, Ferris, S, Goldstein, FC, Giordani, B, Kramer, J, Loewenstein, D, Marson, D, Mungas, D, Salmon, D, Welsh-Bohmer, K, Zhou, X-H, Shirk, SD, Atri, A, Kukull, WA, Phelps, C, and Morris, JC. "Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS)." Alzheimer Disease and Associated Disorders 32.1 (January 2018): 10-17. Full Text

Romero, HR, Monsch, AU, Hayden, KM, Plassman, BL, Atkins, AS, Keefe, RSE, Brewster, S, Chiang, C, O'Neil, J, Runyan, G, Atkinson, MJ, Crawford, S, Budur, K, Burns, DK, and Welsh-Bohmer, KA. "TOMMORROW neuropsychological battery: German language validation and normative study." Alzheimer'S & Dementia (New York, N. Y.) 4 (January 2018): 314-323. Full Text

Atkins, AS, Khan, A, Ulshen, D, Vaughan, A, Balentin, D, Dickerson, H, Liharska, LE, Plassman, B, Welsh-Bohmer, K, and Keefe, RSE. "Assessment of Instrumental Activities of Daily Living in Older Adults with Subjective Cognitive Decline Using the Virtual Reality Functional Capacity Assessment Tool (VRFCAT)." The Journal of Prevention of Alzheimer'S Disease 5.4 (January 2018): 216-234. Full Text

Peloso, GM, van der Lee, SJ, Sims, R, Naj, AC, Bellenguez, C, Badarinarayan, N, Jakobsdottir, J, Kunkle, BW, Boland, A, Raybould, R, Bis, JC, Martin, ER, Grenier-Boley, B, Heilmann-Heimbach, S, Chouraki, V, Kuzma, AB, Sleegers, K, Vronskaya, M, Ruiz, A, Graham, RR, Olaso, R, Hoffmann, P, Grove, ML, Vardarajan, BN, Hiltunen, M, Nöthen, MM, White, CC, Hamilton-Nelson, KL, Epelbaum, J, Maier, W, Choi, SH, Beecham, GW, Dulary, C, Herms, S, Smith, AV, Funk, CC, Derbois, , Forstner, AJ, Ahmad, S, Li, H, Bacq, D, Harold, D, Satizabal, CL, Valladares, O, Squassina, A, Thomas, R, Brody, JA, Qu, L, Sánchez-Juan, P, Morgan, T, Wolters, FJ, Zhao, Y, Garcia, FS, Denning, N, Fornage, M, Malamon, J, Naranjo, MCD, Majounie, E, Mosley, TH, Dombroski, B, Wallon, D, Lupton, MK, Dupuis, J, Whitehead, P, Fratiglioni, L, Medway, C, Jian, X, Mukherjee, S, Keller, L, Brown, K, Lin, H, Cantwell, LB, Panza, F, McGuinness, B, Moreno-Grau, S, Burgess, JD, Solfrizzi, V, Proitsi, P, Adams, HH, Allen, M, Seripa, D, Pastor, P, Cupples, LA, Price, ND, Hannequin, D, Frank-García, A, Levy, D, Chakrabarty, P, Caffarra, P, Giegling, I, Beiser, AS, Giedraitis, V, Hampel, H, Garcia, ME, Wang, X, Lannfelt, L, Mecocci, P, Eiriksdottir, G, and Crane, PK. "Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease." Alzheimer'S and Dementia: Diagnosis, Assessment and Disease Monitoring 10 (January 1, 2018): 595-598. Full Text

Morrison, RL, Pei, H, Novak, G, Kaufer, DI, Welsh-Bohmer, KA, Ruhmel, S, and Narayan, VA. "A computerized, self-administered test of verbal episodic memory in elderly patients with mild cognitive impairment and healthy participants: A randomized, crossover, validation study." Alzheimer'S and Dementia: Diagnosis, Assessment and Disease Monitoring 10 (January 1, 2018): 647-656. Full Text

Sims, R, van der Lee, SJ, Naj, AC, Bellenguez, C, Badarinarayan, N, Jakobsdottir, J, Kunkle, BW, Boland, A, Raybould, R, Bis, JC, Martin, ER, Grenier-Boley, B, Heilmann-Heimbach, S, Chouraki, V, Kuzma, AB, Sleegers, K, Vronskaya, M, Ruiz, A, Graham, RR, Olaso, R, Hoffmann, P, Grove, ML, Vardarajan, BN, Hiltunen, M, Nöthen, MM, White, CC, Hamilton-Nelson, KL, Epelbaum, J, Maier, W, Choi, S-H, Beecham, GW, Dulary, C, Herms, S, Smith, AV, Funk, CC, Derbois, C, Forstner, AJ, Ahmad, S, Li, H, Bacq, D, Harold, D, Satizabal, CL, Valladares, O, Squassina, A, Thomas, R, Brody, JA, Qu, L, Sánchez-Juan, P, Morgan, T, Wolters, FJ, Zhao, Y, Garcia, FS, Denning, N, Fornage, M, Malamon, J, Naranjo, MCD, Majounie, E, Mosley, TH, Dombroski, B, Wallon, D, Lupton, MK, Dupuis, J, Whitehead, P, Fratiglioni, L, Medway, C, Jian, X, Mukherjee, S, Keller, L, Brown, K, Lin, H, Cantwell, LB, Panza, F, McGuinness, B, Moreno-Grau, S, Burgess, JD, Solfrizzi, V, Proitsi, P, Adams, HH, Allen, M, Seripa, D, Pastor, P, Cupples, LA, Price, ND, Hannequin, D, Frank-García, A, Levy, D, Chakrabarty, P, Caffarra, P, Giegling, I, Beiser, AS, Giedraitis, V, Hampel, H, Garcia, ME, Wang, X, Lannfelt, L, Mecocci, P, Eiriksdottir, G, Crane, PK, Pasquier, F, Boccardi, V, Henández, I, Barber, RC, Scherer, M, Tarraga, L, Adams, PM, Leber, M, Chen, Y, Albert, MS, Riedel-Heller, S, Emilsson, V, Beekly, D, Braae, A, Schmidt, R, Blacker, D, Masullo, C, Schmidt, H, Doody, RS, Spalletta, G, Longstreth, WT, Fairchild, TJ, Bossù, P, Lopez, OL, Frosch, MP, Sacchinelli, E, Ghetti, B, Yang, Q, Huebinger, RM, Jessen, F, Li, S, Kamboh, MI, Morris, J, Sotolongo-Grau, O, Katz, MJ, Corcoran, C, Dunstan, M, Braddel, A, Thomas, C, Meggy, A, Marshall, R, Gerrish, A, Chapman, J, Aguilar, M, Taylor, S, Hill, M, Fairén, MD, Hodges, A, Vellas, B, Soininen, H, Kloszewska, I, Daniilidou, M, Uphill, J, Patel, Y, Hughes, JT, Lord, J, Turton, J, Hartmann, AM, Cecchetti, R, Fenoglio, C, Serpente, M, Arcaro, M, Caltagirone, C, Orfei, MD, Ciaramella, A, Pichler, S, Mayhaus, M, Gu, W, Lleó, A, Fortea, J, Blesa, R, Barber, IS, Brookes, K, Cupidi, C, Maletta, RG, Carrell, D, Sorbi, S, Moebus, S, Urbano, M, Pilotto, A, Kornhuber, J, Bosco, P, Todd, S, Craig, D, Johnston, J, Gill, M, Lawlor, B, Lynch, A, Fox, NC, Hardy, J, ARUK Consortium, , Albin, RL, Apostolova, LG, Arnold, SE, Asthana, S, Atwood, CS, Baldwin, CT, Barnes, LL, Barral, S, Beach, TG, Becker, JT, Bigio, EH, Bird, TD, Boeve, BF, Bowen, JD, Boxer, A, Burke, JR, Burns, JM, Buxbaum, JD, Cairns, NJ, Cao, C, Carlson, CS, Carlsson, CM, Carney, RM, Carrasquillo, MM, Carroll, SL, Diaz, CC, Chui, HC, Clark, DG, Cribbs, DH, Crocco, EA, DeCarli, C, Dick, M, Duara, R, Evans, DA, Faber, KM, Fallon, KB, Fardo, DW, Farlow, MR, Ferris, S, Foroud, TM, Galasko, DR, Gearing, M, Geschwind, DH, Gilbert, JR, Graff-Radford, NR, Green, RC, Growdon, JH, Hamilton, RL, Harrell, LE, Honig, LS, Huentelman, MJ, Hulette, CM, Hyman, BT, Jarvik, GP, Abner, E, Jin, L-W, Jun, G, Karydas, A, Kaye, JA, Kim, R, Kowall, NW, Kramer, JH, LaFerla, FM, Lah, JJ, Leverenz, JB, Levey, AI, Li, G, Lieberman, AP, Lunetta, KL, Lyketsos, CG, Marson, DC, Martiniuk, F, Mash, DC, Masliah, E, McCormick, WC, McCurry, SM, McDavid, AN, McKee, AC, Mesulam, M, Miller, BL, Miller, CA, Miller, JW, Morris, JC, Murrell, JR, Myers, AJ, O'Bryant, S, Olichney, JM, Pankratz, VS, Parisi, JE, Paulson, HL, Perry, W, Peskind, E, Pierce, A, Poon, WW, Potter, H, Quinn, JF, Raj, A, Raskind, M, Reisberg, B, Reitz, C, Ringman, JM, Roberson, ED, Rogaeva, E, Rosen, HJ, Rosenberg, RN, Sager, MA, Saykin, AJ, Schneider, JA, Schneider, LS, Seeley, WW, Smith, AG, Sonnen, JA, Spina, S, Stern, RA, Swerdlow, RH, Tanzi, RE, Thornton-Wells, TA, Trojanowski, JQ, Troncoso, JC, Van Deerlin, VM, Van Eldik, LJ, Vinters, HV, Vonsattel, JP, Weintraub, S, Welsh-Bohmer, KA, Wilhelmsen, KC, Williamson, J, Wingo, TS, Woltjer, RL, Wright, CB, Yu, C-E, Yu, L, Garzia, F, Golamaully, F, Septier, G, Engelborghs, S, Vandenberghe, R, De Deyn, PP, Fernadez, CM, Benito, YA, Thonberg, H, Forsell, C, Lilius, L, Kinhult-Stählbom, A, Kilander, L, Brundin, R, Concari, L, Helisalmi, S, Koivisto, AM, Haapasalo, A, Dermecourt, V, Fievet, N, Hanon, O, Dufouil, C, Brice, A, Ritchie, K, Dubois, B, Himali, JJ, Keene, CD, Tschanz, J, Fitzpatrick, AL, Kukull, WA, Norton, M, Aspelund, T, Larson, EB, Munger, R, Rotter, JI, Lipton, RB, Bullido, MJ, Hofman, A, Montine, TJ, Coto, E, Boerwinkle, E, Petersen, RC, Alvarez, V, Rivadeneira, F, Reiman, EM, Gallo, M, O'Donnell, CJ, Reisch, JS, Bruni, AC, Royall, DR, Dichgans, M, Sano, M, Galimberti, D, St George-Hyslop, P, Scarpini, E, Tsuang, DW, Mancuso, M, Bonuccelli, U, Winslow, AR, Daniele, A, Wu, C-K, GERAD/PERADES, CHARGE, ADGC, EADI, , Peters, O, Nacmias, B, Riemenschneider, M, Heun, R, Brayne, C, Rubinsztein, DC, Bras, J, Guerreiro, R, Al-Chalabi, A, Shaw, CE, Collinge, J, Mann, D, Tsolaki, M, Clarimón, J, Sussams, R, Lovestone, S, O'Donovan, MC, Owen, MJ, Behrens, TW, Mead, S, Goate, AM, Uitterlinden, AG, Holmes, C, Cruchaga, C, Ingelsson, M, Bennett, DA, Powell, J, Golde, TE, Graff, C, De Jager, PL, Morgan, K, Ertekin-Taner, N, Combarros, O, Psaty, BM, Passmore, P, Younkin, SG, Berr, C, Gudnason, V, Rujescu, D, Dickson, DW, Dartigues, J-F, DeStefano, AL, Ortega-Cubero, S, Hakonarson, H, Campion, D, Boada, M, Kauwe, JK, Farrer, LA, Van Broeckhoven, C, Ikram, MA, Jones, L, Haines, JL, Tzourio, C, Launer, LJ, Escott-Price, V, Mayeux, R, Deleuze, J-F, Amin, N, Holmans, PA, Pericak-Vance, MA, Amouyel, P, van Duijn, CM, Ramirez, A, Wang, L-S, Lambert, J-C, Seshadri, S, Williams, J, and Schellenberg, GD. "Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease." Nature Genetics 49.9 (September 2017): 1373-1384. Full Text

Jun, GR, Chung, J, Mez, J, Barber, R, Beecham, GW, Bennett, DA, Buxbaum, JD, Byrd, GS, Carrasquillo, MM, Crane, PK, Cruchaga, C, De Jager, P, Ertekin-Taner, N, Evans, D, Fallin, MD, Foroud, TM, Friedland, RP, Goate, AM, Graff-Radford, NR, Hendrie, H, Hall, KS, Hamilton-Nelson, KL, Inzelberg, R, Kamboh, MI, Kauwe, JSK, Kukull, WA, Kunkle, BW, Kuwano, R, Larson, EB, Logue, MW, Manly, JJ, Martin, ER, Montine, TJ, Mukherjee, S, Naj, A, Reiman, EM, Reitz, C, Sherva, R, St George-Hyslop, PH, Thornton, T, Younkin, SG, Vardarajan, BN, Wang, L-S, Wendlund, JR, Winslow, AR, Alzheimer's Disease Genetics Consortium, , Haines, J, Mayeux, R, Pericak-Vance, MA, Schellenberg, G, Lunetta, KL, and Farrer, LA. "Transethnic genome-wide scan identifies novel Alzheimer's disease loci." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 13.7 (July 2017): 727-738. Full Text

Pages

Aisen, P, Touchon, J, Amariglio, R, Andrieu, S, Bateman, R, Breitner, J, Donohue, M, Dunn, B, Doody, R, Fox, N, Gauthier, S, Grundman, M, Hendrix, S, Ho, C, Isaac, M, Raman, R, Rosenberg, P, Schindler, R, Schneider, L, Sperling, R, Tariot, P, Welsh-Bohmer, K, Weiner, M, and Vellas, B. "EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials." January 2017. Full Text

Mackensen, GB, Ti, LK, Phillips-Bute, BG, Mathew, JP, Newman, MF, Grocott, HP, and Neurologic Outcome Research Group (NORG), . "Cerebral embolization during cardiac surgery: impact of aortic atheroma burden." Bja: British Journal of Anaesthesia 91.5 (November 2003): 656-661. Full Text

Swaminathan, M, McCreath, BJ, Phillips-Bute, BG, Newman, MF, Mathew, JP, Smith, PK, Blumenthal, JA, Stafford-Smith, M, and Perioperative Outcomes Research Group, . "Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction." Anesth Analg 95.1 (July 2002): 1-8.

Selected Grants

Metabolic Signatures Underlying Vascular Risk Factors for Alzheimer-type Dementias awarded by National Institutes of Health (Co Investigator). 2015 to 2020

Behavioral and Physiology in Aging awarded by National Institutes of Health (Mentor). 2015 to 2020

Impact of Disclosing Amyloid Imaging Results to Cognitively Normal Individuals awarded by Brigham and Women's Hospital (Principal Investigator). 2015 to 2019

White Matter Damage in Subconcussive Blast Exposure awarded by National Institutes of Health (Co Investigator). 2014 to 2019

NC Registry for Brain Health awarded by State of North Carolina (Principal Investigator). 2018 to 2019

Neuropsychology of Pre-dementia Alzheimer's Disease awarded by NeuroCog Trials (Principal Investigator). 2018 to 2019

Life Course Process of Alzheimer's Disease: Sex Difference and Biosocial Mechanisms awarded by University of North Carolina - Chapel Hill (Co Investigator). 2017 to 2019

Metabolic Networks and Pathways in Alzheimer's Disease awarded by National Institutes of Health (Co Investigator). 2014 to 2019

EXERT awarded by University of California - San Diego (Principal Investigator). 2016 to 2019

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