Leonard Edward White
Associate Professor in Neurology
Education & Training
Ph.D., Washington University 1992
Overview
One important goal of neuroscience is to understand the fundamental principles that shape the developing brain. To achieve this goal, it is necessary to characterize the interactions between sensorimotor behavior, self-organization, and genetically programmed mechanisms of brain development. This interplay between intrinsic and experience-dependent factors is most dynamic during early life, at a time of explosive increase in the numbers and complexity of neural connections. It is precisely this increase in neural capacity that makes possible the rich repertoire of behavior associated with functional maturity. My primary interest is to understand how sensorimotor experience in early life influences — for better or worse — the formation and maturation of functional neural circuits in the cerebral cortex. My collaborators and I believe that our studies are providing insight into the nature of normal brain development and the consequences of disrupting the partnership between intrinsic developmental mechanisms and early sensorimotor experience.
Location
Contact
Coppola, DM, and White, LE. "Forever young: Neoteny, neurogenesis and a critique of critical periods in olfaction." Journal of Bioenergetics and Biomembranes 51.1 (February 2019): 53-63. (Review) Full Text
Allan Johnson, G, Wang, N, Anderson, RJ, Chen, M, Cofer, GP, Gee, JC, Pratson, F, Tustison, N, and White, LE. "Whole mouse brain connectomics." The Journal of Comparative Neurology (October 16, 2018). Full Text
Li, JY, Middleton, DM, Chen, S, White, L, Corado, CR, Vite, C, Bradbury, A, and Provenzale, JM. "Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages." The Neuroradiology Journal 31.2 (April 2018): 168-176. Full Text
Middleton, DM, Li, JY, Chen, SD, White, LE, Dickson, P, Ellinwood, NM, and Provenzale, JM. "Diffusion tensor imaging findings suggestive of white matter alterations in a canine model of mucopolysaccharidosis type I." The Neuroradiology Journal 31.1 (February 2018): 90-94. Full Text
Middleton, DM, Li, JY, Chen, SD, White, LE, Dickson, PI, Matthew Ellinwood, N, and Provenzale, JM. "Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines." The neuroradiology journal 30.5 (October 2017): 454-460. Full Text
Li, JY, Middleton, DM, Chen, S, White, L, Ellinwood, NM, Dickson, P, Vite, C, Bradbury, A, and Provenzale, JM. "Novel region of interest interrogation technique for diffusion tensor imaging analysis in the canine brain." The Neuroradiology Journal 30.4 (August 2017): 339-346. Full Text
Middleton, DM, Li, JY, Lee, HJ, Chen, S, Dickson, PI, Ellinwood, NM, White, LE, and Provenzale, JM. "Diffusion tensor imaging tensor shape analysis for assessment of regional white matter differences." The neuroradiology journal 30.4 (August 2017): 324-329. Full Text
Peterson, DE, Chen, SD, Calabrese, E, White, LE, and Provenzale, JM. "Automated segmentation of the canine corpus callosum for the measurement of diffusion tensor imaging." The Neuroradiology Journal 29.1 (February 2016): 4-12. Full Text
Choi, J, Dickson, P, Calabrese, E, Chen, S, White, L, Ellingwood, M, and Provenzale, JM. "Predicting degree of myelination based on diffusion tensor imagining of canines with mucopolysaccharidosis type I." The Neuroradiology Journal 28.6 (December 2015): 562-573. Full Text
Schottdorf, M, Keil, W, Coppola, D, White, LE, and Wolf, F. "Random Wiring, Ganglion Cell Mosaics, and the Functional Architecture of the Visual Cortex." PLoS computational biology 11.11 (November 17, 2015): e1004602-. Full Text
Pages
White, LE. "A neuroproteomic approach to understanding visual cortical development." Neuroproteomics. January 1, 2009. 215-237.
Taylor, AB, Velkey, JM, Gwyer, J, and White, LE. "Body and Brain: Anatomy of team-based learning in a preclinical science course." March 2015.
Bucur, B, Madden, DJ, Spaniol, J, Provenzale, JM, White, LE, Cabeza, R, and Huettel, SA. "Age-related decreases in cerebral white matter integrity: Implications for episodic and semantic retrieval processes." 2005.
Selected Grants
The Development of Direction Selectivity in Visual Cortex awarded by National Institutes of Health (Co Investigator). 1996 to 2011
A probabilistic concept of sensory cortical function awarded by National Institutes of Health (Co Investigator). 2003 to 2006
Local Circuits and Direction Selectivity in Visual Cortex awarded by National Institutes of Health (Research Associate). 1996 to 2002
Direction Selectivity And Horizontal Connections In Vi awarded by National Institutes of Health (Principal Investigator). 1998 to 1999
Direction Selectivity And Horizontal Connections In V1 awarded by National Institutes of Health (Principal Investigator). 1997 to 1999