Nancy Lee Zucker

Nancy Lee Zucker

Associate Professor in Psychiatry and Behavioral Sciences and Associate Director of Graduate Studies

Education & Training

  • Ph.D., Louisiana State University at Baton Rouge 2000

Overview

Our laboratory studies individuals who have difficulty detecting, interpreting, and/or using signals from their body and using this information to guide adaptive behavior, particularly in interpersonal contexts. Our primary populations of study are individuals struggling with eating disorders and feeding disorders of childhood: conditions that are sine quo non for dysregulation of basic motivational drives. Several conditions are of particular focus due to the presence of profound deficits in interoception or/and integration of internal arousal: anorexia nervosa, a disorder notable for extreme, determined, rigid, and repetitive behaviors promoting malnourishment and the inability to use signals of interoception and proprioception in the service of goal-directed actions, pediatric binge eating, a model of appetitive dysregulation marked for its early occurrence in the life cycle, and childhood feeding disorders, children who evidence early disturbance in the range of foodstuffs they are willing to sample. Study of children allows us to ask different questions about disorder etiology, maintenance, and course as we can minimize the impact of malnutrition on brain function and perhaps better characterize prior learning history.

Our parallel line of research examines how individuals’ sense others when they have difficulties sensing themselves. Increasing evidence suggests that we understand others via embodied enactments of our own experiences. These findings have profound implications for individuals who have dysfunction in the experience of their bodies as it suggests limited capacities to truly understand others’ experiences. By studying these processes in parallel, we hope to better understand how this interaction between sensing ourselves and others unfolds.

Do, EK, Zucker, NL, Huang, ZY, Schechter, JC, Kollins, SH, Maguire, RL, Murphy, SK, Hoyo, C, and Fuemmeler, BF. "Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children." Pediatric Obesity (September 19, 2018). Full Text

Brown, M, Loeb, KL, McGrath, RE, Tiersky, L, Zucker, N, and Carlin, A. "Executive functioning and central coherence in anorexia nervosa: Pilot investigation of a neurocognitive endophenotype." European Eating Disorders Review : the Journal of the Eating Disorders Association 26.5 (September 2018): 489-498. Full Text

Khalsa, SS, Adolphs, R, Cameron, OG, Critchley, HD, Davenport, PW, Feinstein, JS, Feusner, JD, Garfinkel, SN, Lane, RD, Mehling, WE, Meuret, AE, Nemeroff, CB, Oppenheimer, S, Petzschner, FH, Pollatos, O, Rhudy, JL, Schramm, LP, Simmons, WK, Stein, MB, Stephan, KE, Van den Bergh, O, Van Diest, I, von Leupoldt, A, Paulus, MP, Ainley, V, Al Zoubi, O, Aupperle, R, Avery, J, Baxter, L, Benke, C, Berner, L, Bodurka, J, Breese, E, Brown, T, Burrows, K, Cha, Y-H, Clausen, A, Cosgrove, K, Deville, D, Duncan, L, Duquette, P, Ekhtiari, H, Fine, T, Ford, B, Garcia Cordero, I, Gleghorn, D, Guereca, Y, Harrison, NA, Hassanpour, M, Hechler, T, Heller, A, Hellman, N, Herbert, B, Jarrahi, B, Kerr, K, Kirlic, N, Klabunde, M, Kraynak, T, Kriegsman, M, Kroll, J, Kuplicki, R, Lapidus, R, Le, T, Hagen, KL, Mayeli, A, Morris, A, Naqvi, N, Oldroyd, K, Pané-Farré, C, Phillips, R, Poppa, T, Potter, W, Puhl, M, Safron, A, Sala, M, Savitz, J, Saxon, H, Schoenhals, W, Stanwell-Smith, C, Teed, A, Terasawa, Y, Thompson, K, Toups, M, Umeda, S, Upshaw, V, Victor, T, Wierenga, C, Wohlrab, C, Yeh, H-W, Yoris, A, Zeidan, F, Zotev, V, and Zucker, N. "Interoception and Mental Health: A Roadmap." Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 3.6 (June 2018): 501-513. Full Text

Loeb, KL, Radnitz, C, Keller, KL, Schwartz, MB, Zucker, N, Marcus, S, Pierson, RN, Shannon, M, and DeLaurentis, D. "The Application of Optimal Defaults to Improve Elementary School Lunch Selections: Proof of Concept (Accepted)." Journal of School Health 88.4 (April 1, 2018): 265-271. Full Text

Dozmorov, MG, Bilbo, SD, Kollins, SH, Zucker, N, Do, EK, Schechter, JC, Zhang, JJ, Murphy, SK, Hoyo, C, and Fuemmeler, BF. "Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning." Brain, behavior, and immunity (March 24, 2018). Full Text

Merwin, RM, Moskovich, AA, Honeycutt, LK, Lane, JD, Feinglos, M, Surwit, RS, Zucker, NL, Dmitrieva, NO, Babyak, MA, Batchelder, H, and Mooney, J. "Time of Day When Type 1 Diabetes Patients With Eating Disorder Symptoms Most Commonly Restrict Insulin." Psychosomatic Medicine 80.2 (February 2018): 222-229. Full Text

Norris, ML, Spettigue, W, Hammond, NG, Katzman, DK, Zucker, N, Yelle, K, Santos, A, Gray, M, and Obeid, N. "Building evidence for the use of descriptive subtypes in youth with avoidant restrictive food intake disorder." The International Journal of Eating Disorders 51.2 (February 2018): 170-173. Full Text

Egbert, AH, Wilfley, DE, Eddy, KT, Boutelle, KN, Zucker, N, Peterson, CB, Celio Doyle, A, Le Grange, D, and Goldschmidt, AB. "Attention-Deficit/Hyperactivity Disorder Symptoms Are Associated with Overeating with and without Loss of Control in Youth with Overweight/Obesity." Childhood Obesity 14.1 (January 2018): 50-57. Full Text

Shafer, A, Patel, SJ, Bulik, CM, and Zucker, N. "Experimental pretesting of message framing to motivate caregiver self-care among parents of children with eating disorders." Journal of Applied Biobehavioral Research 22.4 (December 2017): e12092-e12092. Full Text

Zucker, NL, Kragel, PA, Wagner, HR, Keeling, L, Mayer, E, Wang, J, Kang, MS, Merwin, R, Simmons, WK, and LaBar, KS. "The Clinical Significance of Posterior Insular Volume in Adolescent Anorexia Nervosa." Psychosomatic Medicine 79.9 (November 2017): 1025-1035. Full Text

Pages

Sweeney, C, Loeb, KL, Parter, A, Hail, L, Zucker, N, and Zucker, N. "Family-based treatment for prodromal anorexia nervosaEmotional experience and regulation in eating disorders: Theory, evidence, and translational application to family treatment (PublishedPublished)." Family Therapy for Adolescent Eating and Weight Disorders: New Applications. March 27, 2015. 157-176. Full Text

Zucker, N, and Harshaw, C. "Emotion, Attention, and Relationships: A Developmental Model of Self-Regulation in Anorexia Nervosa and Related Disordered Eating Behaviors." The Oxford Handbook of Child and Adolescent Eating Disorders Developmental Perspectives. September 18, 2012. Full Text

Kass, AE, Wilfley, DE, Eddy, KT, Boutelle, KN, Zucker, N, Peterson, CB, Le Grange, D, Celio-Doyle, A, and Goldschmidt, AB. "Secretive eating among youth with overweight or obesity." July 2017. Full Text

Selected Grants

Maternal obesity, child executive functions and child weight gain awarded by National Institutes of Health (Co Investigator). 2015 to 2020

Feelings/Body Investigators:Interoceptive Exposure for Children w/Abdominal Pain awarded by National Institutes of Health (Principal Investigator). 2013 to 2019

A Mind Body Approach to ARFID in Young Children: Food and Body Investigators awarded by Global Foundation for Eating Disorders (Principal Investigator). 2018 to 2019

NYU-Duke Lifespan Mental Health Assessment Collaborative awarded by New York University (Principal Investigator). 2018

Defining Remission and Recovery in Eating Disorders awarded by University of North Carolina - Chapel Hill (Principal Investigator). 2016 to 2017

Eating Disorders in Type 1 Diabetes: Mechanisms of Comorbidity awarded by National Institutes of Health (Co Investigator). 2011 to 2015

Neural Mechanisms of Social Reward Valuation and Decision Making awarded by National Institutes of Health (Co Investigator). 2009 to 2014

KAN-DO: A Family-Based Intervention to Prevent Childhood Obesity awarded by National Institutes of Health (Co Investigator). 2006 to 2012

Biomarkers of Interoceptive Awareness in Adolescent Anorexia Nervosa awarded by National Institutes of Health (Principal Investigator). 2009 to 2012

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