Redford B. Williams
Professor of Psychiatry and Behavioral Sciences
Education & Training
M.D., Yale University 1967
My research aims to identify psychosocial factors that are involved in the pathogenesis and course of major medical disorders, to characterize the biobehavioral mechanisms whereby such factors influence disease, and to develop both behavioral and pharmacologic means of preventing or ameliorating the adverse impact of psychosocial factors on health and disease. Specific projects that are currently active include: 1) The influence of hostile personality, social isolation, depression and other psychosocial risk factors upon the development and course of cardiometabolic disease; 2) Biological and genetic mechanisms whereby psychosocial risk factors influence disease development and course; and 3) Behavioral and pharmacologic approaches to ameliorate impact of psychosocial risk factors on disease risk and course.
Brummett, Beverly H., et al. “Correction to: Effects of Environmental Stress and Gender on Associations among Symptoms of Depression and the Serotonin Transporter Gene Linked Polymorphic Region (5-HTTLPR).” Behav Genet, Dec. 2020. Pubmed, doi:10.1007/s10519-020-10029-5. Full Text
Brummett, Beverly H., et al. “Correction to: 5-HTTLPR and Gender Moderate Changes in Negative Affect Responses to Tryptophan Infusion.” Behav Genet, Dec. 2020. Pubmed, doi:10.1007/s10519-020-10030-y. Full Text
Jonassaint, Charles R., et al. “Correction to: Low Life Course Socioeconomic Status (SES) Is Associated with Negative NEO PI-R Personality Patterns.” Int J Behav Med, vol. 27, no. 6, Dec. 2020, p. 737. Pubmed, doi:10.1007/s12529-020-09923-3. Full Text
Jiang, Rong, et al. “Corrigendum to "Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress" [Psychoneuroendocrinology 79 (2017) (May) 13-19].” Psychoneuroendocrinology, vol. 121, Nov. 2020, p. 104861. Pubmed, doi:10.1016/j.psyneuen.2020.104861. Full Text
Singh, Abanish, et al. “Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.” Transl Psychiatry, vol. 10, no. 1, Oct. 2020, p. 351. Pubmed, doi:10.1038/s41398-020-01028-5. Full Text Open Access Copy
Meyer, Thomas, et al. “Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease.” Biochem Genet, vol. 58, no. 4, Aug. 2020, pp. 631–48. Pubmed, doi:10.1007/s10528-020-09967-w. Full Text
Brummett, B. H., et al. “Corrigendum to "Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c" [J. Psychiatr Res. (2010) 44:373-377].” J Psychiatr Res, vol. 126, July 2020, p. 142. Pubmed, doi:10.1016/j.jpsychires.2019.11.003. Full Text
Surwit, Richard S., et al. “Erratum. Hostility, race, and glucose metabolism in nondiabetic individuals. Diabetes Care 2002;25:835-839.” Diabetes Care, vol. 43, no. 3, Mar. 2020, p. 691. Pubmed, doi:10.2337/dc20-er03. Full Text
Brummett, Beverly H., et al. “Systolic Blood Pressure and Socioeconomic Status in a large multi-study population.” Ssm Popul Health, vol. 9, Dec. 2019, p. 100498. Pubmed, doi:10.1016/j.ssmph.2019.100498. Full Text
Abdulrahim, Jawan W., et al. “Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1).” J Am Heart Assoc, vol. 8, no. 21, Nov. 2019, p. e013228. Pubmed, doi:10.1161/JAHA.119.013228. Full Text
Williams, R. B. “Gene by environment interactions: Impact on women’s health.” Psychosocial Stress and Cardiovascular Disease in Women: Concepts, Findings, Future Perspectives, 2015, pp. 151–60. Scopus, doi:10.1007/978-3-319-09241-6_10. Full Text
Williams, R. B. “Hostility, Neuroendocrine Changes, and Health Outcomes.” The Link Between Religion and Health: Psychoneuroimmunology and the Faith Factor, 2010. Scopus, doi:10.1093/acprof:oso/9780195143607.003.0010. Full Text
Jiang, Rong, et al. “The role of brain-derived neurotropic factor (BDNF) genetic variants in exercise training.” Genetic Epidemiology, vol. 44, no. 5, 2020, pp. 491–92.
Williams, Redford B., and Virginia Williams. “THE WILLIAMS LIFESKILLS PROGRAM - A MEANS OF DELIVERING COGNITIVE BEHAVIORAL STRESS MANAGEMENT AND INTERPERSONAL SKILLS TRAINING IN DIVERSE CULTURES AROUND THE WORLD.” Annals of Behavioral Medicine, vol. 54, 2020, pp. S206–S206.
Fisher, Edwin B., et al. “DEFINING THE "IT" IN DISSEMINATION - CONCEPTUALIZATIONS AND STRATEGIES FOR GLOBAL EFFORTS.” Annals of Behavioral Medicine, vol. 54, 2020, pp. S205–S205.
Reavis, Zackery W., et al. “EIGHT-MONTH STABILITY OF PLASMA EPINEPHRINE AND CORTISOL IN FASTED ADULTS AT BASELINE AND IN RESPONSE TO A GLUCOSE BOLUS.” Psychosomatic Medicine, vol. 81, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2019, pp. A41–42.
Georgiades, Anastasia, et al. “EPINEPHRINE, CORTISOL AND NON-ESTERIFIED FATTY ACID LEVELS DURING AN INTRAVENOUS GLUCOSE TOLERANCE TEST ARE ASSOCIATED WITH THE ACUTE INSULIN RESPONSE (AIR), AN EARLY RISK MARKER FOR TYPE 2 DIABETES.” Psychosomatic Medicine, vol. 81, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2019, pp. A42–A42.
Jiang, Rong, et al. “Understanding of DNA methylation in the biological basis of stress related cardiovascular disease.” Genetic Epidemiology, vol. 42, no. 7, WILEY, 2018, pp. 708–708.
Singh, Abanish, et al. “Harmonizing psychosocial stress and CVD-risk variables for developing robust estimates of GxE analyses.” Genetic Epidemiology, vol. 42, no. 7, WILEY, 2018, pp. 731–731.
Georgiades, Anastasia, et al. “REDUCED ADRENAL MEDULLARY ACTIVITY MAY BE IMPORTANT FOR THE MAINTENANCE OF NORMAL GLUCOSE REGULATION IN THE OBESE STATE.” Psychosomatic Medicine, vol. 80, no. 3, LIPPINCOTT WILLIAMS & WILKINS, 2018, pp. A65–A65.
Jiang, Rong, et al. “The effect of Brain- Derived Neurotrophic Factor (BDNF) Val66Met Variants on the Path from Psychosocial Stress to Depression, Body Mass Index and Pre-Clinical Atherosclerosis.” Genetic Epidemiology, vol. 41, no. 7, WILEY, 2017, pp. 665–66.
Jiang, Rong, et al. “Gender Differences in Brain-Derived Neurotrophic Factor (BDNF) Val66Met Variants and Stressful Life Events on Psychological and Metabolic Phenotypes.” Genetic Epidemiology, vol. 41, no. 7, WILEY, 2017, pp. 665–665.
Genes, Environmental Stressors, and the Biobehavioral Pathways to CVD awarded by National Institutes of Health (Principal Investigator). 1997 to 2021
Exploring the Role of Social Environments for the Prevention of Hypertension among Black Females with a History of Chonic Stress awarded by National Institutes of Health (Collaborator). 2019 to 2020
An Innovative Model to Predict Readmissions in Adults with Cardiovascular Disease awarded by National Institutes of Health (Collaborator). 2013 to 2018
Behavior And Physiology In Aging awarded by National Institutes of Health (Mentor). 1999 to 2015
Responses of Myocardial Ischemia to Sertraline Treatment awarded by National Institutes of Health (Co Investigator). 2006 to 2013
Training in Psychological Intervention Research awarded by National Institutes of Health (Training Faculty). 2006 to 2011
Hostility, Race, and Glucose Metabolism awarded by National Institutes of Health (Mentor). 2003 to 2009
PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health (Consultant). 2002 to 2009
PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health (Consultant). 2002 to 2008
Duke Center for Geospatial Medicine awarded by National Institutes of Health (Investigator). 2004 to 2008