Redford B. Williams
Professor of Psychiatry and Behavioral Sciences
Education & Training
M.D., Yale University 1967
My research aims to identify psychosocial factors that are involved in the pathogenesis and course of major medical disorders, to characterize the biobehavioral mechanisms whereby such factors influence disease, and to develop both behavioral and pharmacologic means of preventing or ameliorating the adverse impact of psychosocial factors on health and disease. Specific projects that are currently active include: 1) The influence of hostile personality, social isolation, depression and other psychosocial risk factors upon the development and course of cardiometabolic disease; 2) Biological and genetic mechanisms whereby psychosocial risk factors influence disease development and course; and 3) Behavioral and pharmacologic approaches to ameliorate impact of psychosocial risk factors on disease risk and course.
Fanaroff, Alexander C., et al. “Relationship Between Optimism and Outcomes in Patients With Chronic Angina Pectoris..” Am J Cardiol, vol. 123, no. 9, May 2019, pp. 1399–405. Pubmed, doi:10.1016/j.amjcard.2019.01.036. Full Text
Boyle, Stephen H., et al. “The Effects of Tryptophan Enhancement and Depletion on Plasma Catecholamine Levels in Healthy Individuals..” Psychosom Med, vol. 81, no. 1, Jan. 2019, pp. 34–40. Pubmed, doi:10.1097/PSY.0000000000000637. Full Text
Do, Elizabeth K., et al. “The role of genetic and environmental influences on the association between childhood ADHD symptoms and BMI..” Int J Obes (Lond), vol. 43, no. 1, Jan. 2019, pp. 33–42. Pubmed, doi:10.1038/s41366-018-0236-5. Full Text
Clemow, Lynn P., et al. “Stress management in the workplace for employees with hypertension: a randomized controlled trial..” Transl Behav Med, vol. 8, no. 5, Sept. 2018, pp. 761–70. Pubmed, doi:10.1093/tbm/iby018. Full Text Open Access Copy
Singh, Abanish, et al. “Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses..” Bmc Res Notes, vol. 11, no. 1, July 2018. Pubmed, doi:10.1186/s13104-018-3595-z. Full Text
Brummett, Beverly H., et al. “Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies..” Front Genet, vol. 9, 2018. Pubmed, doi:10.3389/fgene.2018.00423. Full Text
Proeschold-Bell, Rae Jean, et al. “A 2-Year Holistic Health and Stress Intervention: Results of an RCT in Clergy..” Am J Prev Med, vol. 53, no. 3, Sept. 2017, pp. 290–99. Pubmed, doi:10.1016/j.amepre.2017.04.009. Full Text
Jiang, Rong, et al. “Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort..” Am Heart J, vol. 190, Aug. 2017, pp. 40–45. Pubmed, doi:10.1016/j.ahj.2017.05.002. Full Text
Jiang, Rong, et al. “Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress..” Psychoneuroendocrinology, vol. 79, May 2017, pp. 13–19. Pubmed, doi:10.1016/j.psyneuen.2017.02.005. Full Text
Sun, Julia L., et al. “Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients..” Eur J Prev Cardiol, vol. 24, no. 6, Apr. 2017, pp. 591–99. Pubmed, doi:10.1177/2047487316686435. Full Text
Williams, R. B. “Gene by environment interactions: Impact on women’s health.” Psychosocial Stress and Cardiovascular Disease in Women: Concepts, Findings, Future Perspectives, 2015, pp. 151–60. Scopus, doi:10.1007/978-3-319-09241-6_10. Full Text
Williams, R. B. “Hostility, Neuroendocrine Changes, and Health Outcomes.” The Link Between Religion and Health: Psychoneuroimmunology and the Faith Factor, 2010. Scopus, doi:10.1093/acprof:oso/9780195143607.003.0010. Full Text
Reavis, Zackery W., et al. “EIGHT-MONTH STABILITY OF PLASMA EPINEPHRINE AND CORTISOL IN FASTED ADULTS AT BASELINE AND IN RESPONSE TO A GLUCOSE BOLUS.” Psychosomatic Medicine, vol. 81, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2019, pp. A41–42.
Georgiades, Anastasia, et al. “EPINEPHRINE, CORTISOL AND NON-ESTERIFIED FATTY ACID LEVELS DURING AN INTRAVENOUS GLUCOSE TOLERANCE TEST ARE ASSOCIATED WITH THE ACUTE INSULIN RESPONSE (AIR), AN EARLY RISK MARKER FOR TYPE 2 DIABETES.” Psychosomatic Medicine, vol. 81, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2019, pp. A42–A42.
Jiang, Rong, et al. “Understanding of DNA methylation in the biological basis of stress related cardiovascular disease.” Genetic Epidemiology, vol. 42, no. 7, WILEY, 2018, pp. 708–708.
Singh, Abanish, et al. “Harmonizing psychosocial stress and CVD-risk variables for developing robust estimates of GxE analyses.” Genetic Epidemiology, vol. 42, no. 7, WILEY, 2018, pp. 731–731.
Georgiades, Anastasia, et al. “REDUCED ADRENAL MEDULLARY ACTIVITY MAY BE IMPORTANT FOR THE MAINTENANCE OF NORMAL GLUCOSE REGULATION IN THE OBESE STATE.” Psychosomatic Medicine, vol. 80, no. 3, LIPPINCOTT WILLIAMS & WILKINS, 2018, pp. A65–A65.
Jiang, Rong, et al. “The effect of Brain- Derived Neurotrophic Factor (BDNF) Val66Met Variants on the Path from Psychosocial Stress to Depression, Body Mass Index and Pre-Clinical Atherosclerosis.” Genetic Epidemiology, vol. 41, no. 7, WILEY, 2017, pp. 665–66.
Jiang, Rong, et al. “Gender Differences in Brain-Derived Neurotrophic Factor (BDNF) Val66Met Variants and Stressful Life Events on Psychological and Metabolic Phenotypes.” Genetic Epidemiology, vol. 41, no. 7, WILEY, 2017, pp. 665–665.
Jiang, Rong, et al. “Brain-Derived Neurotrophic Factor Val66Met Variants (RS6265) are Associated with Coronary Heart Disease (CHD) Outcomes in a Patient Sample.” Genetic Epidemiology, vol. 40, no. 7, WILEY-BLACKWELL, 2016, pp. 643–643.
Singh, Abanish, et al. “Follow-up of GxE Interactions: EBF1 GxE Association, Synthetic Chronic Psychosocial Stress, and Dropout from a Structured Exercise Program.” Genetic Epidemiology, vol. 40, no. 7, WILEY-BLACKWELL, 2016, pp. 662–63.
Samad, Zainab, et al. “Sex Differences in Platelet Reactivity, Cardiovascular and Psychological Response to Mental Stress in Patients With Known Coronary Artery Disease: Data From the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment Study.” Circulation, vol. 128, no. 22, LIPPINCOTT WILLIAMS & WILKINS, 2013.
Genes, Environmental Stressors, and the Biobehavioral Pathways to CVD awarded by National Institutes of Health (Principal Investigator). 1997 to 2021
Positive Social Determinants of Health and Blood Pressure among Young Black Women with a History of Early Life Stress awarded by National Institutes of Health (Collaborator). 2019 to 2021
An Innovative Model to Predict Readmissions in Adults with Cardiovascular Disease awarded by National Institutes of Health (Collaborator). 2013 to 2018
Behavior And Physiology In Aging awarded by National Institutes of Health (Mentor). 1999 to 2015
Responses of Myocardial Ischemia to Sertraline Treatment awarded by National Institutes of Health (Co Investigator). 2006 to 2013
Training in Psychological Intervention Research awarded by National Institutes of Health (Training Faculty). 2006 to 2011
Hostility, Race, and Glucose Metabolism awarded by National Institutes of Health (Mentor). 2003 to 2009
PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health (Consultant). 2002 to 2009
PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health (Consultant). 2002 to 2008
Duke Center for Geospatial Medicine awarded by National Institutes of Health (Investigator). 2004 to 2008