Redford B. Williams

Redford B. Williams

Professor of Psychiatry and Behavioral Sciences

Education & Training

  • M.D., Yale University 1967

Overview

My research aims to identify psychosocial factors that are involved in the pathogenesis and course of major medical disorders, to characterize the biobehavioral mechanisms whereby such factors influence disease, and to develop both behavioral and pharmacologic means of preventing or ameliorating the adverse impact of psychosocial factors on health and disease. Specific projects that are currently active include: 1) The influence of hostile personality, social isolation, depression and other psychosocial risk factors upon the development and course of cardiometabolic disease; 2) Biological and genetic mechanisms whereby psychosocial risk factors influence disease development and course; and 3) Behavioral and pharmacologic approaches to ameliorate impact of psychosocial risk factors on disease risk and course.

Do, EK, Haberstick, BC, Williams, RB, Lessem, JM, Smolen, A, Siegler, IC, and Fuemmeler, BF. "The role of genetic and environmental influences on the association between childhood ADHD symptoms and BMI." International Journal of Obesity (2005) (October 22, 2018). Full Text

Boyle, SH, Brummett, BH, Kuhn, CM, Barefoot, JC, Siegler, IC, Williams, RB, and Georgiades, A. "The effects of tryptophan enhancement and depletion on plasma catecholamine levels in healthy individuals." Psychosomatic Medicine (September 4, 2018). Full Text

Clemow, LP, Pickering, TG, Davidson, KW, Schwartz, JE, Williams, VP, Shaffer, JA, Williams, RB, and Gerin, W. "Stress management in the workplace for employees with hypertension: a randomized controlled trial." Translational Behavioral Medicine 8.5 (September 2018): 761-770. Full Text Open Access Copy

Singh, A, Babyak, MA, Brummett, BH, Kraus, WE, Siegler, IC, Hauser, ER, and Williams, RB. "Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses." Bmc Research Notes 11.1 (July 24, 2018): 504-null. Full Text

Brummett, BH, Babyak, MA, Singh, A, Hauser, ER, Jiang, R, Huffman, KM, Kraus, WE, Shah, SH, Siegler, IC, and Williams, RB. "Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies." Frontiers in Genetics 9 (January 2018): 423-null. Full Text

Proeschold-Bell, RJ, Turner, EL, Bennett, GG, Yao, J, Li, X-F, Eagle, DE, Meyer, RA, Williams, RB, Swift, RY, Moore, HE, Kolkin, MA, Weisner, CC, Rugani, KM, Hough, HJ, Williams, VP, and Toole, DC. "A 2-Year Holistic Health and Stress Intervention: Results of an RCT in Clergy." American journal of preventive medicine 53.3 (September 2017): 290-299. Full Text

Jiang, R, Babyak, MA, Brummett, BH, Hauser, ER, Shah, SH, Becker, RC, Siegler, IC, Singh, A, Haynes, C, Chryst-Ladd, M, Craig, DM, and Williams, RB. "Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort." American Heart Journal 190 (August 2017): 40-45. Full Text

Jiang, R, Babyak, MA, Brummett, BH, Siegler, IC, Kuhn, CM, and Williams, RB. "Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress." Psychoneuroendocrinology 79 (May 2017): 13-19. Full Text

Sun, JL, Boyle, SH, Samad, Z, Babyak, MA, Wilson, JL, Kuhn, C, Becker, RC, Ortel, TL, Williams, RB, Rogers, JG, O'Connor, CM, Velazquez, EJ, and Jiang, W. "Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients." European Journal of Preventive Cardiology 24.6 (April 2017): 591-599. Full Text

Williams, RB, Bishop, GD, Haberstick, BC, Smolen, A, Brummett, BH, Siegler, IC, Babyak, MA, Zhang, X, Tai, ES, Lee, JJ-M, Tan, M, Teo, YY, Cai, S, Chan, E, Halpern, CT, Whitsel, EA, Bauldry, S, and Harris, KM. "Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence." American heart journal 185 (March 2017): 110-122. Full Text

Pages

Williams, RB. "Gene by environment interactions: Impact on women’s health." Psychosocial Stress and Cardiovascular Disease in Women: Concepts, Findings, Future Perspectives. January 1, 2015. 151-160. Full Text

Williams, RB. "Hostility, Neuroendocrine Changes, and Health Outcomes." The Link Between Religion and Health: Psychoneuroimmunology and the Faith Factor. April 1, 2010. Full Text

Jiang, R, Kwee, L, Shah, SH, Singh, A, Babyak, MA, Brummett, BH, Siegler, IC, Williams, RB, and Hauser, ER. "Understanding of DNA methylation in the biological basis of stress related cardiovascular disease." 27th Annual Meeting of the International-Genetic-Epidemiology-Society (IGES). October 14, 2018 - October 16, 2018. San Diego, CA.: WILEY, October 1, 2018.

Singh, A, Babyak, MA, Brummett, BH, Kraus, WE, Siegler, IC, Hauser, ER, and Williams, RB. "Harmonizing psychosocial stress and CVD-risk variables for developing robust estimates of GxE analyses." 27th Annual Meeting of the International-Genetic-Epidemiology-Society (IGES). October 14, 2018 - October 16, 2018. San Diego, CA.: WILEY, October 1, 2018.

Georgiades, A, Surwit, RS, Lane, JD, Siegler, IC, Kuhn, CM, Brummett, BH, Boyle, SH, Babyak, MA, Costa, P, and Williams, RB. "REDUCED ADRENAL MEDULLARY ACTIVITY MAY BE IMPORTANT FOR THE MAINTENANCE OF NORMAL GLUCOSE REGULATION IN THE OBESE STATE." 76th Annual Scientific Meeting of the American-Psychosomatic-Society - Optimizing Health and Resilience in a Changing World - Celebrating 75 Years of the American Psychosomatic Society. March 7, 2018 - March 10, 2018. Louisville, KY.: LIPPINCOTT WILLIAMS & WILKINS, April 1, 2018.

Jiang, R, Babyak, MA, Brummett, BH, Hauser, ER, Haberstick, BC, Smolen, A, Siegler, IC, Harris, KM, and Williams, RB. "Gender Differences in Brain-Derived Neurotrophic Factor (BDNF) Val66Met Variants and Stressful Life Events on Psychological and Metabolic Phenotypes." November 2017.

Singh, A, Hauser, ER, Johnson, JL, Babyak, MA, Brummett, BH, Jiang, R, Slentz, CA, Huffman, KM, Siegler, IC, Williams, RB, and Kraus, WE. "Follow-up of GxE Interactions: EBF1 GxE Association, Synthetic Chronic Psychosocial Stress, and Dropout from a Structured Exercise Program." November 2016.

Jiang, R, Babyak, MA, Brummett, BH, Hauser, ER, Singh, A, Siegler, IC, Shah, SH, Haynes, C, Chryst-Ladd, M, and Williams, RB. "Brain-Derived Neurotrophic Factor Val66Met Variants (RS6265) are Associated with Coronary Heart Disease (CHD) Outcomes in a Patient Sample." November 2016.

Brummett, BH, Babyak, MA, Jiang, R, Singh, A, Williams, RB, Harris, KM, and Siegler, IC. "BIOBEHAVIORAL MEDIATORS OF SES EFFECTS ON CRP IN A NATIONALLY REPRESENTATIVE US SAMPLE." April 2013.

Williams, RB, Bishop, GD, Haberstick, BC, Smolen, A, Helms, MJ, Brummett, BH, Siegler, IC, Babyak, MA, Zhang, X, Tai, ES, Lee, JM, Tan, M, Teo, Y-Y, Cai, S, Chan, E, Halpern, CT, Whitsel, EA, Shanahan, MJ, Bauldry, S, and Harris, KM. "POPULATION DIFFERENCES IN ASSOCIATIONS OF SEROTONIN TRANSPORTER PROMOTER POLYMORPHISM (5HTTLPR) DI- AND TRIALLELIC GENOTYPES WITH BLOOD PRESSURE AND HYPERTENSION PREVALENCE." April 2013.

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Selected Grants

Genes, environmental stressors, and the biobehavioral pathways to CVD awarded by National Institutes of Health (Principal Investigator). 1997 to 2021

An Innovative Model to Predict Readmissions in Adults with Cardiovascular Disease awarded by National Institutes of Health (Collaborator). 2013 to 2018

Behavior And Physiology In Aging awarded by National Institutes of Health (Mentor). 1999 to 2015

Responses of Myocardial Ischemia to Sertraline Treatment awarded by National Institutes of Health (Co Investigator). 2006 to 2013

Training in Psychological Intervention Research awarded by National Institutes of Health (Training Faculty). 2006 to 2011

Hostility, Race, and Glucose Metabolism awarded by National Institutes of Health (Mentor). 2003 to 2009

PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health (Consultant). 2002 to 2009

PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health (Consultant). 2002 to 2008

Duke Center for Geospatial Medicine awarded by National Institutes of Health (Investigator). 2004 to 2008

Surveillance And Analysis Of The UNC Alumni Heart Study awarded by National Institutes of Health (Co Investigator). 1996 to 2007

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