Redford B. Williams

Redford B. Williams

Professor of Psychiatry and Behavioral Sciences

Education & Training

  • M.D., Yale University 1967

Overview

My research aims to identify psychosocial factors that are involved in the pathogenesis and course of major medical disorders, to characterize the biobehavioral mechanisms whereby such factors influence disease, and to develop both behavioral and pharmacologic means of preventing or ameliorating the adverse impact of psychosocial factors on health and disease. Specific projects that are currently active include: 1) The influence of hostile personality, social isolation, depression and other psychosocial risk factors upon the development and course of cardiometabolic disease; 2) Biological and genetic mechanisms whereby psychosocial risk factors influence disease development and course; and 3) Behavioral and pharmacologic approaches to ameliorate impact of psychosocial risk factors on disease risk and course.

Brummett, Beverly H., et al. “Correction to: 5-HTTLPR and Gender Moderate Changes in Negative Affect Responses to Tryptophan Infusion.Behav Genet, Dec. 2020. Pubmed, doi:10.1007/s10519-020-10030-y. Full Text

Jonassaint, Charles R., et al. “Correction to: Low Life Course Socioeconomic Status (SES) Is Associated with Negative NEO PI-R Personality Patterns.Int J Behav Med, vol. 27, no. 6, Dec. 2020, p. 737. Pubmed, doi:10.1007/s12529-020-09923-3. Full Text

Singh, Abanish, et al. “Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.Transl Psychiatry, vol. 10, no. 1, Oct. 2020, p. 351. Pubmed, doi:10.1038/s41398-020-01028-5. Full Text Open Access Copy

Brummett, B. H., et al. “Corrigendum to "Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c" [J. Psychiatr Res. (2010) 44:373-377].J Psychiatr Res, vol. 126, July 2020, p. 142. Pubmed, doi:10.1016/j.jpsychires.2019.11.003. Full Text

Surwit, Richard S., et al. “Erratum. Hostility, race, and glucose metabolism in nondiabetic individuals. Diabetes Care 2002;25:835-839.Diabetes Care, vol. 43, no. 3, Mar. 2020, p. 691. Pubmed, doi:10.2337/dc20-er03. Full Text

Brummett, Beverly H., et al. “Systolic Blood Pressure and Socioeconomic Status in a large multi-study population.Ssm Popul Health, vol. 9, Dec. 2019, p. 100498. Pubmed, doi:10.1016/j.ssmph.2019.100498. Full Text

Abdulrahim, Jawan W., et al. “Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1).J Am Heart Assoc, vol. 8, no. 21, Nov. 2019, p. e013228. Pubmed, doi:10.1161/JAHA.119.013228. Full Text

Pages

Williams, R. B. “Gene by environment interactions: Impact on women’s health.” Psychosocial Stress and Cardiovascular Disease in Women: Concepts, Findings, Future Perspectives, 2015, pp. 151–60. Scopus, doi:10.1007/978-3-319-09241-6_10. Full Text

Williams, R. B. “Hostility, Neuroendocrine Changes, and Health Outcomes.” The Link Between Religion and Health: Psychoneuroimmunology and the Faith Factor, 2010. Scopus, doi:10.1093/acprof:oso/9780195143607.003.0010. Full Text

Jiang, Rong, et al. “The role of brain-derived neurotropic factor (BDNF) genetic variants in exercise training.” Genetic Epidemiology, vol. 44, no. 5, 2020, pp. 491–92.

Williams, Redford B., and Virginia Williams. “THE WILLIAMS LIFESKILLS PROGRAM - A MEANS OF DELIVERING COGNITIVE BEHAVIORAL STRESS MANAGEMENT AND INTERPERSONAL SKILLS TRAINING IN DIVERSE CULTURES AROUND THE WORLD.” Annals of Behavioral Medicine, vol. 54, 2020, pp. S206–S206.

Fisher, Edwin B., et al. “DEFINING THE "IT" IN DISSEMINATION - CONCEPTUALIZATIONS AND STRATEGIES FOR GLOBAL EFFORTS.” Annals of Behavioral Medicine, vol. 54, 2020, pp. S205–S205.

Reavis, Zackery W., et al. “EIGHT-MONTH STABILITY OF PLASMA EPINEPHRINE AND CORTISOL IN FASTED ADULTS AT BASELINE AND IN RESPONSE TO A GLUCOSE BOLUS.” Psychosomatic Medicine, vol. 81, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2019, pp. A41–42.

Jiang, Rong, et al. “Understanding of DNA methylation in the biological basis of stress related cardiovascular disease.” Genetic Epidemiology, vol. 42, no. 7, WILEY, 2018, pp. 708–708.

Singh, Abanish, et al. “Harmonizing psychosocial stress and CVD-risk variables for developing robust estimates of GxE analyses.” Genetic Epidemiology, vol. 42, no. 7, WILEY, 2018, pp. 731–731.

Georgiades, Anastasia, et al. “REDUCED ADRENAL MEDULLARY ACTIVITY MAY BE IMPORTANT FOR THE MAINTENANCE OF NORMAL GLUCOSE REGULATION IN THE OBESE STATE.” Psychosomatic Medicine, vol. 80, no. 3, LIPPINCOTT WILLIAMS & WILKINS, 2018, pp. A65–A65.

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Selected Grants

Genes, Environmental Stressors, and the Biobehavioral Pathways to CVD awarded by National Institutes of Health (Principal Investigator). 1997 to 2021

An Innovative Model to Predict Readmissions in Adults with Cardiovascular Disease awarded by National Institutes of Health (Collaborator). 2013 to 2018

Behavior And Physiology In Aging awarded by National Institutes of Health (Mentor). 1999 to 2015

Responses of Myocardial Ischemia to Sertraline Treatment awarded by National Institutes of Health (Co Investigator). 2006 to 2013

Training in Psychological Intervention Research awarded by National Institutes of Health (Training Faculty). 2006 to 2011

Hostility, Race, and Glucose Metabolism awarded by National Institutes of Health (Mentor). 2003 to 2009

PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health (Consultant). 2002 to 2009

PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health (Consultant). 2002 to 2008

Duke Center for Geospatial Medicine awarded by National Institutes of Health (Investigator). 2004 to 2008

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