Richard S.E. Keefe

Richard S.E. Keefe

Professor in Psychiatry and Behavioral Sciences

Education & Training

  • Ph.D., New York University 1990


Schizophrenia, psychosis, cognition, pharmacologic treatment of cognitive impairment, sport psychology, functional imaging (PET, fMRI), frontal cortex, motor functions.

Kraus, MS, Walker, TM, Jarskog, LF, Millet, RA, and Keefe, RSE. "Basic auditory processing deficits and their association with auditory emotion recognition in schizophrenia." Schizophrenia Research 204 (February 2019): 155-161. Full Text

Wang, C, Lee, J, Ho, NF, Lim, JKW, Poh, JS, Rekhi, G, Krishnan, R, Keefe, RSE, Adcock, RA, Wood, SJ, Fornito, A, Chee, MWL, and Zhou, J. "Large-Scale Network Topology Reveals Heterogeneity in Individuals With at Risk Mental State for Psychosis: Findings From the Longitudinal Youth-at-Risk Study." Cerebral Cortex (New York, N.Y. : 1991) 28.12 (December 2018): 4234-4243. Full Text

Keefe, RSE, and Pani, L. "Take This Cognitive Training Efficacy Bar Fight Outside (to a Regulatory Agency)." Biological Psychiatry. Cognitive Neuroscience and Neuroimaging 3.11 (November 2018): 900-902. Full Text

Yang, Z, Lim, K, Lam, M, Keefe, R, and Lee, J. "Factor structure of the positive and negative syndrome scale (PANSS) in people at ultra high risk (UHR) for psychosis." Schizophrenia Research 201 (November 2018): 85-90. Full Text

Lam, M, Lee, J, Rapisarda, A, See, YM, Yang, Z, Lee, S-A, Abdul-Rashid, NA, Kraus, M, Subramaniam, M, Chong, S-A, and Keefe, RSE. "Longitudinal Cognitive Changes in Young Individuals at Ultrahigh Risk for Psychosis." Jama Psychiatry 75.9 (September 2018): 929-939. Full Text

Xavier, RM, Dungan, JR, Keefe, RSE, and Vorderstrasse, A. "Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia." Schizophrenia Research. Cognition 12 (June 2018): 11-19. Full Text

Blokland, GAM, Del Re, EC, Mesholam-Gately, RI, Jovicich, J, Trampush, JW, Keshavan, MS, DeLisi, LE, Walters, JTR, Turner, JA, Malhotra, AK, Lencz, T, Shenton, ME, Voineskos, AN, Rujescu, D, Giegling, I, Kahn, RS, Roffman, JL, Holt, DJ, Ehrlich, S, Kikinis, Z, Dazzan, P, Murray, RM, Di Forti, M, Lee, J, Sim, K, Lam, M, Wolthusen, RPF, de Zwarte, SMC, Walton, E, Cosgrove, D, Kelly, S, Maleki, N, Osiecki, L, Picchioni, MM, Bramon, E, Russo, M, David, AS, Mondelli, V, Reinders, AATS, Falcone, MA, Hartmann, AM, Konte, B, Morris, DW, Gill, M, Corvin, AP, Cahn, W, Ho, NF, Liu, JJ, Keefe, RSE, Gollub, RL, Manoach, DS, Calhoun, VD, Schulz, SC, Sponheim, SR, Goff, DC, Buka, SL, Cherkerzian, S, Thermenos, HW, Kubicki, M, Nestor, PG, Dickie, EW, Vassos, E, Ciufolini, S, Reis Marques, T, Crossley, NA, Purcell, SM, Smoller, JW, van Haren, NEM, Toulopoulou, T, Donohoe, G, Goldstein, JM, Seidman, LJ, McCarley, RW, and Petryshen, TL. "The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project." Schizophrenia Research 195 (May 2018): 306-317. Full Text

Xavier, RM, Vorderstrasse, A, Keefe, RSE, and Dungan, JR. "Genetic correlates of insight in schizophrenia." Schizophrenia Research 195 (May 2018): 290-297. Full Text

Keefe, RSE, Nomikos, G, Zhong, W, Christensen, MC, and Jacobson, W. "A Subgroup Analysis of the Impact of Vortioxetine on Functional Capacity, as Measured by UPSA, in Patients with Major Depressive Disorder and Subjective Cognitive Dysfunction." The International Journal of Neuropsychopharmacology 21.5 (May 2018): 442-447. Full Text


Vance, M, Pappadopulos, E, Keefe, R, and Kalali, A. "Conceptual issues in cultural adaptation and the role of culture in assessment of health-related quality of life in schizophrenia." Beyond Assessment of Quality of Life in Schizophrenia. January 1, 2016. 53-62. Full Text

Eum, S, Hill, SK, Rubin, LH, Carnahan, RM, Reilly, JL, Ivleva, EI, Keedy, SK, Tamminga, CA, Pearlson, GD, Clementz, BA, Gershon, ES, Keshavan, MS, Keefe, RSE, Sweeney, JA, and Bishop, JR. "Cognitive burden of anticholinergic medications in psychotic disorders." December 2017. Full Text

Graham, KA, Keefe, RS, Lieberman, JA, Calikoglu, AS, Lansing, KM, and Perkins, DO. "Relationship of low vitamin D status with positive, negative and cognitive symptom domains in people with first-episode schizophrenia." October 2015. Full Text

Madhoo, M, Roth, RM, Keefe, RSE, Sambunaris, A, Scheckner, B, Nielsen, J, Adeyi, B, Wu, J, and Lasser, R. "P.2.a.017 Lisdexamfetamine dimesylate augmentation effects on executive function in major depressive disorder based on depressive symptom levels.": Elsevier BV, October 2012. Full Text

Madhoo, M, Keefe, RSE, Roth, RM, Sambunaris, A, Wu, J, Trivedi, MH, Anderson, CS, and Lasser, R. "Efficacy and safety of lisdexamfetamine dimesylate in adults with executive dysfunction and partial or full remission of major depressive disorder.": OXFORD UNIV PRESS, June 1, 2012.


Uchida, H, Sakurai, H, Bies, RR, Stroup, S, Keefe, RSE, Suzuki, T, Tsuboi, T, Mimura, M, Pollock, BG, and Mamo, DC. "DOPAMINE D2 RECEPTOR OCCUPANCY AND COGNITION IN SCHIZOPHRENIA: ANALYSIS OF THE CATIE DATA." April 2012.

Colijn, MA, Barbato, M, Keefe, RS, Perkins, DO, Woods, SW, and Addington, J. "Poster #143 AT RISK FOR PSYCHOSIS: THE ROLE OF COGNITION." April 2012. Full Text

Keefe, RS, Buchanan, RW, Marder, SR, Schooler, NR, Dugar, A, Zivkov, M, and Stewart, M. "Poster #199 CLINICAL TRIALS OF POTENTIAL COGNITIVE-ENHANCING DRUGS IN SCHIZOPHRENIA: WHAT HAVE WE LEARNED SO FAR?." April 2012. Full Text


Selected Grants

BI 1289.32 Phase II Clinical Trial awarded by Boehringer Ingelheim Pharmaceuticals, Inc. (Principal Investigator). 2017 to 2020

Auditory Perception and Emotion Recognition in Young People at Risk for Psychosis awarded by National Institutes of Health (Principal Investigator). 2016 to 2019

FAST- MAS Phase 2A awarded by National Institutes of Health (Co Investigator). 2013 to 2017

Specific Auditory Perception Impairment and Emotion Recognition in Schizophrenia awarded by National Institutes of Health (Principal Investigator). 2014 to 2017

FAST- MAS Administrative Task Year 3 awarded by National Institutes of Health (Co Investigator). 2014 to 2015

IPA - Richard Keefe awarded by Durham Veterans Affairs Medical Center (Research Associate). 2013 to 2014

IPA - Richard Keefe awarded by Veterans Administration Medical Center (Research Associate). 2012 to 2013

IPA - Richard Keefe awarded by Veterans Administration Medical Center (Fellow). 2010 to 2011

Neural Circuitry And Cognitive Function In Schizophrenia awarded by National Institutes of Health (Principal Investigator). 1995 to 2001

Neural Circuitry & Cognitive Function In Schizophrenia awarded by National Institutes of Health (Principal Investigator). 1995 to 1999