Warren H. Meck
Professor of Psychology and Neuroscience
Education & Training
Ph.D., Brown University 1982
Overview
Research interests include the neuroanatomical and neuropharmacological basis of timing and time perception in the seconds-to-minutes range. This work relates to the striatal beat-frequency theory of interval timing as well as mode-control models of temporal integration and attentional time-sharing in humans and other animals. Current work focuses on the use of genomic and ensemble-recording techniques designed to identify the basic properties of interval timing and decision making in cortical-striatal circuits. Additional work utilizes neuroimaging techniques (e.g., EEG & fMRI) to examine temporal processing deficits in selected clinical populations. Another major focus for our research uses animal models to study developmental periods of dietary choline sensitivity that provide an ontogenetic mechanism for regulating memory capacity and precision in adulthood. This work includes the study of prenatal choline effects on sleep-dependent memory consolidation processes in adult rats and mice as well as inoculation against age-related impairments in spatial and temporal cognition.
Expertise
Neuroanatomical and neuropharmacological basis of timing and time perception
Location
Contact
Petter, EA, Gershman, SJ, and Meck, WH. "Integrating Models of Interval Timing and Reinforcement Learning." Trends in Cognitive Sciences 22.10 (October 2018): 911-922. (Review) Full Text
Bareš, M, Apps, R, Avanzino, L, Breska, A, D'Angelo, E, Filip, P, Gerwig, M, Ivry, RB, Lawrenson, CL, Louis, ED, Lusk, NA, Manto, M, Meck, WH, Mitoma, H, and Petter, EA. "Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications." Cerebellum (London, England) (September 27, 2018). (Review) Full Text
Gu, B-M, Kukreja, K, and Meck, WH. "Oscillation patterns of local field potentials in the dorsal striatum and sensorimotor cortex during the encoding, maintenance, and decision stages for the ordinal comparison of sub- and supra-second signal durations." Neurobiology of Learning and Memory 153.Pt A (September 2018): 79-91. (Review) Full Text
Toda, K, Lusk, NA, Watson, GDR, Kim, N, Lu, D, Li, HE, Meck, WH, and Yin, HH. "Nigrotectal Stimulation Stops Interval Timing in Mice." Current Biology : Cb 27.24 (December 2017): 3763-3770.e3. Full Text
Teki, S, Gu, B-M, and Meck, WH. "The Persistence of Memory: How the Brain Encodes Time in Memory." Current Opinion in Behavioral Sciences 17 (October 2017): 178-185. Full Text
Petter, EA, Lusk, NA, Hesslow, G, and Meck, WH. "Interactive roles of the cerebellum and striatum in sub-second and supra-second timing: Support for an initiation, continuation, adjustment, and termination (ICAT) model of temporal processing." Neuroscience and Biobehavioral Reviews 71 (December 2016): 739-755. (Review) Full Text
Schirmer, A, Meck, WH, and Penney, TB. "The Socio-Temporal Brain: Connecting People in Time." Trends in cognitive sciences 20.10 (October 2016): 760-772. (Review) Full Text
Matthews, WJ, and Meck, WH. "Temporal cognition: Connecting subjective time to perception, attention, and memory." Psychological Bulletin 142.8 (August 2016): 865-907. (Review) Full Text
Lake, JI, LaBar, KS, and Meck, WH. "Emotional modulation of interval timing and time perception." Neuroscience and Biobehavioral Reviews 64 (May 2016): 403-420. (Review) Full Text
Lusk, NA, Petter, EA, MacDonald, CJ, and Meck, WH. "Cerebellar, hippocampal, and striatal time cells." Current Opinion in Behavioral Sciences 8 (April 1, 2016): 186-192. (Review) Full Text
Pages
Allman, MJ, Yin, B, and Meck, WH. "Time in the psychopathological mind." Subjective Time: The Philosophy, Psychology, and Neuroscience of Temporality. January 1, 2014. 637-654.
Matell, MS, Meck, WH, and Nicolelis, MAL. "Integration of behavior and timing: Anatomically separate systems or distributed processing?." Functional and Neural Mechanisms of Interval Timing. January 1, 2003. 370-392.
MacDonald, CJ, and Meck, WH. "Time flies and may also sing: Cortico-striatal mechanisms of interval timing and birdsong." Functional and Neural Mechanisms of Interval Timing. January 1, 2003. 392-418.
Meck, WH. Functional and neural mechanisms of interval timing. January 1, 2003.
Introduction: The persistence of time. January 1, 2003.
Selected Grants
Collaborative Research: Understanding the Role of Writing in Promoting Learning and Engagement for Diverse Thesis Writer awarded by National Science Foundation (Faculty Member). 2012 to 2016
REU Site: Research Program in Mechanisms of Behavior awarded by National Science Foundation (Principal Investigator). 2004 to 2014
Representation of Temporal Information awarded by National Institutes of Health (Co-Principal Investigator). 2006 to 2010
Attentional Processing of Temporal Information awarded by National Institutes of Health (Co-Principal Investigator). 2002 to 2008
Center for Behavioral Neuroscience and Genomics awarded by National Institutes of Health (Co Investigator). 2002 to 2004
Undergraduate Neurosciences Summer Research Program in Mechanisms of Behavior awarded by National Science Foundation (Principal Investigator). 1999 to 2002
Functional and Neural Mechanisms of Interval Timing awarded by National Institute of Mental Health (NIMH) (Principal Investigator). 1997 to 2002
(97-0016) Functional and Neural Mechanisms of Interval Timing in Rats awarded by National Institute of Mental Health (NIMH) (Principal Investigator). 1997 to 2001
Nicotines Effect on Interval Timing -- FMRI Assessment awarded by National Institutes of Health (Co-Principal Investigator). 1999 to 2000
Interval Timing Behavior: Ensemble Recording and Stimulants awarded by National Institutes of Health (Principal Investigator). 1997 to 2000