Under what circumstances are we most likely to make wise decisions? And what conditions push us toward forgettable or regrettable choices? While quantitative models of economic, political, and medical decision-making often assume 'rationality,' this course addresses the exercise of choice under physiological, emotional, and psychological stressors. Topics include: neuroanatomic sub-strates of executive function; the physiologic impact of acute and chronic stress responses; cognitive biases; and the effect of evidence, advisors, and experiential learning on reaching conclusions. Focus on neuroanatomical & physiological underpinnings of stress responses and rendering judgments.